社区老年人肌少症与非酶糖基化水平和心血管疾病的相关性研究

doi:10.3969/j.issn.1003-9198.2021.09.005

Abstract

Abstract: Objective To investigate the characteristics of sarcopenia in the community elderly and the correlation between sarcopenia and non-enzymatic glycosylation level and common cardiovascular diseases. Methods A total of 110 participants who lived in Jiangsu Province Elderly Apartment were selected, and they were divided into sarcopenia group (n=38) and non-sarcopenia group (n=72) according to the guidelines of Asian Working Group for Sarcopenia. The clinical data and the incidence rates of cardiovascular diseases (heart failure, coronary heart disease, hypertension) were compared between the two groups, and the risk factors of sarcopenia were evaluated by Logistic regression analysis.The levels of carboxymethyl lysine(CML) and soluble receptor for advanced glycation end products(sRAGE) in 60 subjects were detected by enzyme linked immunosorbent assay, and the levels of CML, sRAGE,advanced glycation end products (AGEs)/sRAGE in sarcopenia group and non-sarcopenia group were compared. Results Compared with non-sarcopenia group, the age, and the levels of C-reaction protein (CRP) and high density lipoprotein cholesterol (HDL-C) in sarcopenia group were significantly higher, while the levels of body mass index (BMI), skeletal muscle mass index (SMI), grip strength, 4 m walking speed, hemoglobin and albumin were significantly lower(P＜0.05 or P＜0.01). The incidence rates of heart failure and coronary heart disease in sarcopenia group were significantly higher than those in non-sarcopenia group (P＜0.05), but there was no difference in the incidence rate of hypertension between the two groups (P>0.05). After adjustment for gender, age, BMI, SMI, HDL-C and CRP, multivariate Logistic regression analysis showed that coronary heart disease and heart failure were not independent influencing factors for sarcopenia in the elderly. The levels of CML and AGEs/sRAGE in sarcopenia population were significantly higher than those in non-sarcopenia population (P＜0.05), and there was no difference in sRAGE level between the two groups (P=0.587). Conclusions The levels of CML and AGEs/sRAGE in the sarcopenia population are significantly higher than those in the non-sarcopenia population. The community elderly with coronary heart disease and heart failure are more likely to suffer from carcopenia.

Key words: aged, cardiovascular disease, sarcopenia, non-enzymatic glywsylation

CLC Number:

R 592

FAN Tian-shu, ZHAO Wen-xue, LU Miao, WANGXiang-ming, ZHA Zhi-min, CAO Ya-ru, GUO Yan. Correlation between sarcopenia and non-enzymatic glycosylation and cardiovascular disease in the community elderly[J]. Practical Geriatrics, 2021, 35(9): 910-913.

References

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Correlation between sarcopenia and non-enzymatic glycosylation and cardiovascular disease in the community elderly

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