老年人体力活动水平与肌少症发生风险关系的剂量-反应Meta分析

doi:10.3969/j.issn.1003-9198.2024.09.011

Abstract

Abstract: Objective To explore the dose-response association between physical activity and sarcopenia based on a Meta-analysis. Methods PubMed, Web of Science, Embase, VIP, Wanfang Database, SinoMed and CNKI databases were searched to collect cohort studies about physical activity and the risk of sarcopenia from the establishment of the database to May 2023. Two researchers independently completed literature screening and data extraction and quality assessment. Meta-analysis was conducted with Stata 17.0 and RevMan 5.4 software to calculate pooled odds ratio (OR) and corresponding 95% confidence interval (CI), and the dose-response relationship between physical activity and risk of sarcopenia was analyzed by using restricted cubic spline function and generalized least squares estimation. Results A total of 6 studies involving 8784 participants and 1275 sarcopenic patients were included.The results of Meta-analysis revealed that physical activity was negatively correlated with sarcopenia (OR=0.59, 95%CI :0.52-0.67). Low heterogeneity was shown, and no publication bias was found. Nonlinear dose-response analysis showed a U-shaped association between physical activity and sarcopenia. When the level of physical activity reached 10.85 mMET-h/wk, the preventive effect on sarcopenia was the most significant (OR＝0.40, 95%CI:0.32-0.50). Conclusions Elderly people can achieve substantial and significant benefits in preventing sarcopenia by increasing their physical activity levels, even when the level is lower than 8.8 mMET-h/wk recommended by the World Health Organization. The protective effect of sarcopenia is most obvious when the level of physical activity reaches 10.85 mMET-h/wk.

Key words: sarcopenia, physical activity, cohort study, Meta-analysis

CLC Number:

R685

QI Jiaying, YIN Tongtong, WANG Fangfang, ZHANG Hui, WANG Li. A dose-response Meta-analysis of the association between physical activity and the risk of sarcopenia in the elderly[J]. Practical Geriatrics, 2024, 38(9): 905-910.

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A dose-response Meta-analysis of the association between physical activity and the risk of sarcopenia in the elderly

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