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20 September 2024, Volume 38 Issue 9 Previous Issue    Next Issue

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Correlation between preoperative SII/ALB and clinicopathologic features in elderly patients with lung adenocarcinoma LI Jiang, QIU Yan, WANG Ting, WANG Dan, YU Yifan, PU Lingli, BU Ling 2024, 38 (9):  893-896.  doi: 10.3969/j.issn.1003-9198.2024.09.008 Abstract ( 66 )   PDF (1035KB) ( 430 )   Save Objective To investigate the correlation between preoperative systemic immunoinflammatory index/serum albumin (SII/ALB) and clinicopathological features in the elderly patients with lung adenocarcinoma. Methods The clinicopathological data of 103 elderly patients with lung adenocarcinoma treated by thoracoscopic surgery in Geriatric Hospital of Nanjing Medical University from January 2020 to June 2023 were retrospectively analyzed. SII/ALB value was calculated according to preoperative test results, and the patients were divided into high SII/ALB group and low SII/ALB group according to the median SII/ALB value. The relationship between SII/ALB and clinicopathological features of the patients was analyzed. Results The median SII/ALB was 16.1, and there were 47 cases in low SII/ALB group (SII/ALB≤16.1) and 56 cases in high SII/ALB group (SII/ALB > 16.1). There were significant differences in BMI, high-grade adenocarcinoma components, pleural invasion, TNM stage, lymph node metastasis and airway spread between the two groups (P<0.05). The level ofSII/ALB was correlated with TNM stage and lymph node metastasis (P<0.05). Conclusions SII/ALB reflects the immune, inflammatory and nutritional status of the patients. SII/ALB level is related to TNM stage and lymph node metastasis. Monitoring SII/ALB level is helpful to provide certain reference information for the clinical diagnosis and treatment of elderly lung adenocarcinoma. References | Related Articles | Metrics

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Effects of three drugs combined with high-energy red light irradiation in the treatment of herpes zoster in the elderly CAO Lu, ZHAO Yang, TU Haiyan 2024, 38 (9):  897-900.  doi: 10.3969/j.issn.1003-9198.2024.09.009 Abstract ( 64 )   PDF (1030KB) ( 150 )   Save Objective To evaluate the clinical efficacy of valacyclovir, pregabalin and mecobalamin combined with high-energy red light irradiation in the treatment of herpes zoster (HZ) in the elderly, and to explore the possible mechanism. Methods A total of 90 elderly patients with acute HZ were randomly divided into the experimental group and the control group, with 45 cases in each group. The control group was treated with drugs as valacyclovir, pregabalin and mecobalamin, and the experimental group was treated with high-energy red light irradiation on the basis of the drug treatment.The score of Visual Analogue Scale (VAS), serum levels of interleukin-2(IL-2), IL-6 and tumor necrosis factor-α (TNF-α) before treatment, 7 days and 4 weeks after treatment were detected, and the clinical efficacy of the two groups was assessed and compared. Results The VAS scores of the two groups after 7 days and 4 weeks of treatment were significantly lower than those before treatment (P<0.05), especially in the experimental group (P<0.05). Compared with those before treatment, the levels of IL-2 7 days and 4 weeks after treatment were increased, and the levels of IL-6 and TNF-α were decreased in the two groups(P<0.05), especially in the experimental group (P<0.05). The effective rate in the experimental group was 86.67%, compared with 66.67% in the control group (P<0.05). Conclusions Valacyclovir, pregabalin and mecobalamin combined with high-energy red light irradiation is more effective in the treatment of the elderly patients with HZ, and its mechanism may be related to the regulation of immune response and the reduction of inflammation. References | Related Articles | Metrics

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Risk factors of lymph node metastasis in elderly patients with mixed-type early gastric cancer WANG Zhenyu, YUAN Ying, XIANG Ying, LIU Jinyan, WU Hai, WANG Meng, XU Guifang 2024, 38 (9):  901-904.  doi: 10.3969/j.issn.1003-9198.2024.09.010 Abstract ( 68 )   PDF (1085KB) ( 191 )   Save Objective To investigate the risk factors of lymph node metastasis(LNM) in the elderly patients with mixed-type early gastric cancer(EGC). Methods The clinicopathological features of the elderly patients with mixed-type EGC undergoing radical gastrectomy and lymph node dissection from January 2010 to March 2023 at Nanjing Drum Tower Hospital were retrospectively analyzed. The risk factors of LNM in the elderly patients with mixed-type EGC were analyzed by univariate analysis and Logistic regression analysis. Results A total of 212 elderly patients with mixed-type EGC were enrolled,and 44 (20.8%) cases presented with lymph node metastasis.Univariate analysis indicated that tumor location (P=0.035), tumor size (P=0.006), invasion depth (P<0.001) and vascular invasion (P<0.001) were related with LNM. Multivariate regression analysis showed that tumor located at lower third of stomach(OR=4.109,95%CI:1.128-14.961,P=0.032), submucosal infiltration (OR=3.640,95%CI:1.163-11.391,P=0.026) and vascular invasion(OR=3.684,95%CI:1.602-8.470,P=0.002)were the independent risk factors for LNM. Conclusions Tumor location, depth of invasion and vascular invasion are the independent risk factors of LNM in the elderly patients with mixed-type EGC. References | Related Articles | Metrics

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A dose-response Meta-analysis of the association between physical activity and the risk of sarcopenia in the elderly QI Jiaying, YIN Tongtong, WANG Fangfang, ZHANG Hui, WANG Li 2024, 38 (9):  905-910.  doi: 10.3969/j.issn.1003-9198.2024.09.011 Abstract ( 51 )   PDF (2067KB) ( 225 )   Save Objective To explore the dose-response association between physical activity and sarcopenia based on a Meta-analysis. Methods PubMed, Web of Science, Embase, VIP, Wanfang Database, SinoMed and CNKI databases were searched to collect cohort studies about physical activity and the risk of sarcopenia from the establishment of the database to May 2023. Two researchers independently completed literature screening and data extraction and quality assessment. Meta-analysis was conducted with Stata 17.0 and RevMan 5.4 software to calculate pooled odds ratio (OR) and corresponding 95% confidence interval (CI), and the dose-response relationship between physical activity and risk of sarcopenia was analyzed by using restricted cubic spline function and generalized least squares estimation. Results A total of 6 studies involving 8784 participants and 1275 sarcopenic patients were included.The results of Meta-analysis revealed that physical activity was negatively correlated with sarcopenia (OR=0.59, 95%CI :0.52-0.67). Low heterogeneity was shown, and no publication bias was found. Nonlinear dose-response analysis showed a U-shaped association between physical activity and sarcopenia. When the level of physical activity reached 10.85 mMET-h/wk, the preventive effect on sarcopenia was the most significant (OR＝0.40, 95%CI:0.32-0.50). Conclusions Elderly people can achieve substantial and significant benefits in preventing sarcopenia by increasing their physical activity levels, even when the level is lower than 8.8 mMET-h/wk recommended by the World Health Organization. The protective effect of sarcopenia is most obvious when the level of physical activity reaches 10.85 mMET-h/wk. References | Related Articles | Metrics

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Relationship of bone mineral density and fracture risk with type 2 diabetes mellitus-related factors in elderly patients GAO Yuan, CHEN Hua, CHEN Ke, HUANG Wenlong 2024, 38 (9):  911-915.  doi: 10.3969/j.issn.1003-9198.2024.09.012 Abstract ( 46 )   PDF (1050KB) ( 186 )   Save Objective To investigate the relationship of type 2 diabetes mellitus (T2DM)-related factors with bone mineral density (BMD) and fracture risk in the elderly T2DM patients. Methods The clinical data of 307 elderly patients with T2DM were collected. The 10-year probability of a major osteoporotic fracture (PMOF) and the 10-year probability of a hip fracture(PHF) were estimated using Fracture Risk Assessment Tool (FRAX). The relationship of T2DM-related factors such as disease duration, the levels of insulin and C-peptide, medication usage with BMD and the risk of fracture were explored. Results With the increase of T2DM duration, BMD showed no significant change (P>0.05), while PMOF, PHF increased significantly (Ptrend<0.05). The level of BMD at lumbar spine(L1, L3, L4)and femur neck(FN)in the patients receiving insulin-injection were higher than those in the patients receiving oral hypoglycemic agents. With the increase of the levels of insulin and C-peptide, the levels of BMD at L1-2 and FN showed a gradual increasing trend(Ptrend<0.05), but there was no statistically significant difference in PMOF and PHF (P>0.05). In the linear regression, BMD at L1 was positively correlated with the level of insulin and insulin injection, and negatively correlated with neuropathy and hypoglycemia (P<0.05); PMOF and PHF had a positive correlation with hypoglycemia and diabetic vascular disease (P<0.05). Conclusions There is complex relationship of BMD and fracture risk with T2DM-related factors.BMD may increase with the usage of insulin, while fracture risk increases with disease duration, complication and hypoglycemia. Therefore, it is necessary to screen the high risk of fracture in the elderly patients with T2DM. References | Related Articles | Metrics

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Study on the diagnostic value of BALF mNGS for pulmonary aspergillosis in elderly patients LI Rui, MIAO Guiling, LI Shanshan, REN Lijun, TIAN Yaqiong 2024, 38 (9):  916-919.  doi: 10.3969/j.issn.1003-9198.2024.09.013 Abstract ( 38 )   PDF (1038KB) ( 126 )   Save Objective To investigate the diagnostic value of bronchial alveolar lavage fluid (BALF) metagenomic next-generation sequencing (mNGS) for pulmonary aspergillosis in the elderly patients. Methods A total of 190 patients with pulmonary aspergillosis were enrolled in this study, and were divided into the elderly group and the non-elderly group. The diagnostic value of traditional microbial culture, serum galactomannan antigen (GM) test, BALF GM test and BALF mNGS were investigated in the two groups. Results The positive rate of BALF mNGS was highest in the elderly group and the non-elderly group, followed by BALF GM test. There was significant difference in the positive rate of GM test between the two groups. Receiver operating characteristic (ROC) curve analysis showed that the diagnostic efficiency of BALF GM test was higher than that of serum GM test in the elderly group and the non-elderly group. The sensitivity and specificity of BALF GM test in the elderly group were higher than those in the non-elderly group.A total of 61 cases out of 99 elderly patients presenting with serum GM test less than 0.5 underwent BALF mNGS, and the positive rate of aspergillus was 80.3%. A total of 26 cases out of 28 elderly patients presenting with BALF GM test less than 0.8 underwent BALF mNGS, and the positive rate of aspergillus was 100%. Conclusions In the diagnosis of pulmonary aspergillosis in the elderly patients, the positive rate of BALF mNGS was higher than GM test and traditional microbial culture. Thus, BALF mNGS shows better diagnostic efficacy. In the elderly patients who are highly suspected of aspergillus infection despite the negative results of traditional microbial detection and GM test, BALF mNGS is an advantageous supplementary detection method. References | Related Articles | Metrics

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Clinical characteristics and prognostic analysis of elderly and young patients with AIDS-related lymphoma LIAN Yun, JIANG Wen, ZHU Fang, CHENG Yu, ZHAO Huihui 2024, 38 (9):  920-925.  doi: 10.3969/j.issn.1003-9198.2024.09.014 Abstract ( 47 )   PDF (1089KB) ( 192 )   Save Objective To compare the clinical characteristics and prognosis of AIDS-related lymphoma (ARL) between the elderly patients and the young patients. Methods This study retrospectively enrolled 55 patients with newly diagnosed ARL from 2009 to 2023 in our hospital.According to the quantitative and qualitative data, the factors affecting the overall survival time(OS) were analyzed by Cox regression. Results All the patients were divided into elderly group(15 cases, aged ≥60 years) and young group(40 cases,aged <60 years). Compared with the elderly patients, the young patients were prone to presenting with the symptoms of group B (P=0.009). All patients were followed up until August 31, 2023, and the mortality rate and median OS of the elderly patients was 53.3%(8/15) and 14.3 months, compared with 47.5%(19/40) and 13.4 months in the young patients. There were no significant differences in mortality (P=0.700) and OS (P=0.872) between the two groups. Univariate survival analysis revealed that standardized therapy (P=0.010) affected the prognosis of elderly patients, and IPI score (P=0.015), CD4+ T cell count (P=0.039), group B symptoms (P=0.016), hepatitis C antibody (P=0.025), standardized treatment (P=0.011) were associated with OS in young group. Multiple survival analysis showed that IPI score (P=0.042) was the independent risk factor affecting the prognosis of young patients. Conclusions B-cell lymphoma is the main type of ARL, and most of them show high risk of death. All the patients should receive standardized treatment to improve prognosis. References | Related Articles | Metrics

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Comparison of clinical efficacy of aminocaproic acid and tranexamic acid in perioperative period of elderly patients with intertrochanteric fractures LI Tangbo, MA Bingtao, LIU Linlin, XU Jianqiang 2024, 38 (9):  926-930.  doi: 10.3969/j.issn.1003-9198.2024.09.015 Abstract ( 101 )   PDF (1058KB) ( 170 )   Save Objective To compare the clinical efficacy of aminocaproic acid and tranexamic acid in reducing perioperative blood loss in the elderly patients with intertrochanteric fractures undergoing closed reduction and internal fixation with intramedullary nailing. Methods A retrospective analysis was conducted to assess the clinical data of 98 elderly patients who underwent surgery for intertrochanteric fractures from January 2020 to December 2022.The patients were divided into two groups based on intravenous administration of either aminocaproic acid (48 cases) or tranexamic acid (50 cases). Blood loss indicators and the incidence rate of complications were compared between the two groups. Results There were no significant differences in age, gender, height, weight, body mass index (BMI), preoperative hematocrit and total blood volume between the groups (P>0.05). The total blood loss volume and hidden blood loss volume within 24 hours after surgery, blood transfusion rate, total transfusion volume in the tranexamic acid group were significantly lower than those in the aminocaproic acid group (P<0.05). However, there were no significant differences in total blood loss and hidden blood loss 24-72 hours after surgery, hematocrit at 24 and 72 hours, intraoperative blood loss volume, postoperative drainage, hospital stay, operation time and the incidence rate of postoperative venous thrombosis and poor wound healing between the two groups (P>0.05). Conclusions The use of tranexamic acid during surgery in the elderly patients with intertrochanteric fractures is more effective in reducing perioperative blood loss volume, particularly hidden blood loss, compared to aminocaproic acid.Therefore, tranexamic acid is recommended as the preferred antifibrinolytic agent during surgery for intertrochanteric fractures in the elderly patients. References | Related Articles | Metrics

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Correlation between glycosylated hemoglobin variability and cognitive dysfunction in elderly patients with type 2 diabetes mellitus DAI Jing, CUI Yan 2024, 38 (9):  931-935.  doi: 10.3969/j.issn.1003-9198.2024.09.016 Abstract ( 50 )   PDF (1627KB) ( 221 )   Save Objective To evaluate the correlation of the level and variability of glycosylated hemoglobin (HbA1c) with cognitive dysfunction in the elderly patients with type 2 diabetes mellitus (T2DM). Methods A total of 477 elderly patients with T2DM were retrospectively selected from the Diabetes Center of Jiangsu Province Official Hospital who received more than 3 times of glycosylated hemoglobin measurement within 24 months.According to the score of Mini-Mental Status Exam (MMSE), the patients were divided into normal cognitive function group (332 cases) and cognitive dysfunction group (145 cases).Based on the levels of HbA1c, HbA1c-mean and HbA1c variation indicators, including HbA1c standard deviation(HbA1c-SD), HbA1c coefficient of variation (HbA1c-CV), HbA1c standard deviation corrected for measurement frequency (Adj HbA1c-SD) were calculated.The correlation of HbA1c level and variability with cognitive impairment was analyzed. Results The levels of HbA1c-mean and the HbA1c variation indicators in cognitive dysfunction group were significantly higher than those in normal cognitive function group (P＜0.05).Logistic regression analysis showed that HbA1c-mean and the variation indicators of HbA1c were independent risk factors for the occurrence of cognitive dysfunction (P＜0.05).After controlling confounding factors, the results of restricted cubic spline analysis showed that there was a linear dose-response relationship between the level of HbA1c-mean and cognitive impairment, and there was a nonlinear dose-response relationship between HbA1c-SD, HbA1c-CV,Adj-HbA1c-SD and cognitive impairment. Conclusions HbA1c variability is independently associated with cognitive impairment in the elderly patients with T2DM and it should be given attention in clinical practice. References | Related Articles | Metrics

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Effects of hypnotics on cognition function and daytime sleepiness in the elderly ZHENG Hong, QI Zhenbo, XU Peng, XU Jie, YU Xinyu, ZANG Yanan, ZHANG Zhaoyan 2024, 38 (9):  936-939.  doi: 10.3969/j.issn.1003-9198.2024.09.017 Abstract ( 50 )   PDF (1021KB) ( 173 )   Save Objective To investigate the effects of long-term use of hypnotics on daytime sleepiness and cognitive function in the elderly. Methods A total of 103 elderly patients aged ≥80 years old who were hospitalized in our hospital were enrolled in this study. They were divided into the hypnotic group and the control group according to whether they took hypnotics. The cognitive function and daytime sleepiness in the two groups were assessed respectively by Montreal Cognitive Assessment Scale (MoCA) and Epworth Sleepiness Scale (ESS) and compared. Results The incidence of daytime sleepiness showed no significant difference between the two groups (P＞0.05). The scores of ESS showed that the incidence rates of severe sleepiness in dull public places or while sitting quietly after lunch in the control group were significantly higher than those in the hypnotic group (P<0.05).The scores of MoCA showed that there was statistically significant difference in (language) naming between the hypnotic group and the control group (P<0.05). Conclusions Reasonable and effective hypnotic drug treatment for the elderly with insomnia has no adverse effect on cognitive function and daytime sleepiness, so hypnotic drugs can be used to strengthen the intervention of sleep problems in the elderly. References | Related Articles | Metrics

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Investigation on the relationship between different physical indexes and the risk of diabetes mellitus in the elderly ZHANG Xingxing, ZHANG Haiyang, HE Xiaojing, LU Xiang 2024, 38 (9):  940-943.  doi: 10.3969/j.issn.1003-9198.2024.09.018 Abstract ( 66 )   PDF (1040KB) ( 261 )   Save Objective To analyze the relationship between obesity indexes such as BMI, waist circumference (WC), lipid accumulation product (LAP), Chinese visceral adiposity index (CVAI), body roundness index (BRI), and diabetes in the elderly, and to explore the predictive effects of these indexes for diabetes in the elderly. Methods A stratified random cluster sampling method was employed, covering 10 streets in Jiangning District, Nanjing.A total of 56 410 elderly individuals who met the criteria and participated physical examinations in the community health service centers from January to December 2021 were enrolled in this study. The data of physical examination and laboratory indexes were collected. The elderly were divided into the diabetes group and the non-diabetes group based on whether they presented with diabetes, and the differences in the indexes between the two groups were compared.Logistic regression analysis was used to explore the correlation between various obesity indexes and diabetes, and receiver operating characteristic (ROC) curve analysis was used to assess the predictive value of these indexes for diabetes. Results Compared with the non-diabetes group, there were statistically significant differences in gender, age, education level, marital status, smoking status, alcohol consumption, hypertension, dyslipidemia, and the levels of BMI, WC, LAP, CVAI and BRI in the diabetes group (P<0.05). The area under the curve (AUC) of BMI, WC, LAP, CVAI, BRI, and the combination of these five indexes in predicting diabetes in the elderly was 0.593, 0.590, 0.599, 0.618, 0.590 and 0.620, respectively. Conclusions BMI, WC, LAP, CVAI and BRI are risk factors for diabetes. The combination of these five indexes shows better predictive value for diabetes than those alone. References | Related Articles | Metrics

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Effects of electroacupuncture on cognitive function and inflammatory factors in elderly patients undergoing lower limb orthopedic surgery during the perioperative period NI Hongyan, CHEN Yun, ZHANG Qibing, MA Yiming, XIE Chenglan 2024, 38 (9):  944-947.  doi: 10.3969/j.issn.1003-9198.2024.09.019 Abstract ( 44 )   PDF (1033KB) ( 221 )   Save Objective To observe the effects of postoperative electroacupuncture treatment on perioperative neurocognitive dysfunction (PND) and the levels of inflammatory factors in the elderly patients undergoing lower limb orthopedic surgery under general anaesthesia. Methods Eighty elderly patients undergoing lower limb orthopedic surgery under general anaesthesia were selected and randomly divided into the control group and the acupuncture group, with 40 cases in each group. Both groups were given the same anaesthetic method. The control group was given conventional treatment after surgery, and the acupuncture group was treated with electroacupuncture on the basis of conventional treatment. Cognitive function was assessed before and 1, 3 and 7 days after surgery using the Mini Mental State Examination (MMSE), and the serum levels of the inflammatory factors such as tumor necrosis factor-α (TNF-α), interleukin (IL)-1β and IL-6 were measured in the two groups. Results The incidence rate of PND in the acupuncture group was lower than that in the control group on the first day and the third day after operation, with significant differences (P < 0.05). In the acupuncture group, the serum levels of TNF-α and IL-6 were significantly lower than those in the control group on the first day, the third day and the seventh day after operation (P < 0.05), and the level of IL-1β was lower than that in the control group on the first day and the third day after operation. On the first, third and 7th day after operation, the MMSE score was negatively correlated with the levels of TNF-α, IL-1β, IL-6 in the acupucture group. Conclusions Electroacupuncture treatment can reduce the incidence of perioperative cognitive function in the elderly patients undergoing lower limb orthopedic surgery, and the effects can be related to the inhibition of inflammatory factors expression by electroacupuncture. References | Related Articles | Metrics

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Efficiency influencing factors of transanal double-balloon enteroscopy in elderly patients LI Xiaomin, LI Xiaolin, LI Jie, WU Lei, HAO Ranran 2024, 38 (9):  958-961.  doi: 10.3969/j.issn.1003-9198.2024.09.022 Abstract ( 49 )   PDF (1028KB) ( 245 )   Save Objective To explore the efficiency and influencing factors of transanal double balloon enteroscopy (DBE) in the elderly patients. Methods The clinical data of 180 elderly patients aged over 60 years old who underwent transanal DBE examination in the Geriatric Endoscopy Center of our hospital from March 2022 to October 2023 were retrospectively analyzed. The general information of the elderly patients was collected, and the quality of intestinal preparation was evaluated by the Ottawa bowel preparation score(OBPS). The efficiency of transanal DBE was calculated according to the ratio of the depth of enteroscopy and operation time and the patients were divided into high efficiency group and low efficiency group. The influencing factors of the efficiency of enteroscopy were analyzed by multiple Logistic regression. Results The univariate analysis showed that the surgical site, polyp or diverticulum disease and cecal intubation time (CIT) were related to the efficiency of transanal DBE. Multiple Logistic regression analysis showed that polyp or diverticulum disease, surgical site and time of insertion into cecum were risk factors of the efficiency of transanal DBE in the elderly patients. Patients with a history of lower abdominal surgery showed low efficiency in transanal DBE. Conclusions The history of lower abdominal surgery, polyp or diverticulum disease and long CIT reduce the efficiency of transanal DBE in the elderly patients. References | Related Articles | Metrics

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Construction of a medical and nursing hospice service model based on embeddedness theory SUN Lulu, ZHOU Yujie, DONG Shan, ZHOU Mingfei, YIN Xiaoli, PANG Tianyu, YAN Kairan, ZHOU Mian, YUAN Ling 2024, 38 (9):  962-967.  doi: 10.3969/j.issn.1003-9198.2024.09.023 Abstract ( 48 )   PDF (1051KB) ( 175 )   Save Objective To construct a scientific and standardized medical hospice service model based on the theory of embeddedness, and to provide guidance for the development of hospice services. Methods Through using “embeddedness theory” as a theoretical guide, the first-level entries were identified as institutional embeddedness, structural embeddedness, cognitive embeddedness and cultural embeddedness. The framework of the healthcare hospice model was initially developed through literature research and group discussion, and 15 experts in related fields such as hospice, healthcare integration and geriatric specialties were invited for 2 rounds of expert correspondence using the Delphi method of expert correspondence. Results The two rounds of questionnaires had a recovery rate and validity rate of 100.0%, with an expert authority coefficient of 0.930 and 0.930, and Kendall’s harmony coefficients of 0.231 and 0.254, respectively (P<0.001), resulting in a model of medical and nursing hospice care services that included four first-level entries, eight second-level entries, and 50 third-level entries. Conclusions The medical hospice service model based on the theory of embeddedness has a high degree of reliability and scientific validity, which can improve the quality of life of the terminally ill elderly and provide guidance for hospice practice in the context of medical integration. References | Related Articles | Metrics

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Effects of diversified health education model with simple respiratory function exercise on cancer-related fatigue and compliance behavior in elderly patients with lung cancer receiving radiotherapy CAI Huicui, CHEN Yan, WANG Yan, YE Jinjun, ZHU Yuying 2024, 38 (9):  968-972.  doi: 10.3969/j.issn.1003-9198.2024.09.024 Abstract ( 51 )   PDF (1045KB) ( 210 )   Save Objective To explore the effects of diversified health education mode combined with simple respiratory function exercise for elderly patients with lung cancer undergoing radiotherapy. Methods A prospective study was conducted in 60 patients with lung cancer undergoing radiotherapy admitted to our hospital from March 2021 to September 2023. They were divided into the study group (30 cases) and the control group (30 cases) according to the random number table method. The control group received routine nursing intervention, and the study group received diversified health education model combined with simple respiratory function exercise intervention. The cancer-related fatigue [evaluated by Piper fatigue scale (PFS)], quality of life [evaluated by quality of life core questionnaire (QLQ-C30)], respiratory function [including exhaled nitric oxide (FeNO), respiratory rate and oxygenation index], compliance behavior and nursing intervention satisfaction score (evaluated by patient care needs and satisfaction questionnaire) were compared between the two groups before and after intervention. Results Before intervention, there were no significant differences in PFS, QLQ-C30 scores, and the levels of FeNO, respiratory rate, oxygenation index between the two groups (P>0.05). After 3 months of intervention, the above indexes in 2 groups were significantly improved(P<0.05), especially in the study group(P<0.05).During the nursing period, the compliance rate and satisfaction score of nursing intervention in the study group were significantly higher than those in the control group (P<0.05). Conclusions Diversified health education model combined with simple respiratory function exercise intervention can significantly improve cancer-related fatigue, improve elderly patients’ compliance and quality of life, and enhance their satisfaction with nursing intervention, which has good application value. References | Related Articles | Metrics