糖化血红蛋白变异性与老年2型糖尿病病人认知功能障碍的相关性分析

doi:10.3969/j.issn.1003-9198.2024.09.016

Abstract

Abstract: Objective To evaluate the correlation of the level and variability of glycosylated hemoglobin (HbA1c) with cognitive dysfunction in the elderly patients with type 2 diabetes mellitus (T2DM). Methods A total of 477 elderly patients with T2DM were retrospectively selected from the Diabetes Center of Jiangsu Province Official Hospital who received more than 3 times of glycosylated hemoglobin measurement within 24 months.According to the score of Mini-Mental Status Exam (MMSE), the patients were divided into normal cognitive function group (332 cases) and cognitive dysfunction group (145 cases).Based on the levels of HbA1c, HbA1c-mean and HbA1c variation indicators, including HbA1c standard deviation(HbA1c-SD), HbA1c coefficient of variation (HbA1c-CV), HbA1c standard deviation corrected for measurement frequency (Adj HbA1c-SD) were calculated.The correlation of HbA1c level and variability with cognitive impairment was analyzed. Results The levels of HbA1c-mean and the HbA1c variation indicators in cognitive dysfunction group were significantly higher than those in normal cognitive function group (P＜0.05).Logistic regression analysis showed that HbA1c-mean and the variation indicators of HbA1c were independent risk factors for the occurrence of cognitive dysfunction (P＜0.05).After controlling confounding factors, the results of restricted cubic spline analysis showed that there was a linear dose-response relationship between the level of HbA1c-mean and cognitive impairment, and there was a nonlinear dose-response relationship between HbA1c-SD, HbA1c-CV,Adj-HbA1c-SD and cognitive impairment. Conclusions HbA1c variability is independently associated with cognitive impairment in the elderly patients with T2DM and it should be given attention in clinical practice.

Key words: glycated hemoglobin variability, type 2 diabetes mellitus, cognitive impairment, aged

CLC Number:

R587.2

DAI Jing, CUI Yan. Correlation between glycosylated hemoglobin variability and cognitive dysfunction in elderly patients with type 2 diabetes mellitus[J]. Practical Geriatrics, 2024, 38(9): 931-935.

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Correlation between glycosylated hemoglobin variability and cognitive dysfunction in elderly patients with type 2 diabetes mellitus

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