老年特发性间质性肺炎病人血清S100A9及sCD163表达水平及临床意义

doi:10.3969/j.issn.1003-9198.2024.08.011

Abstract

Abstract: Objective To study the levels of serum S100 calcium binding protein A9 (S100A9) and soluble CD163 (sCD163) in the elderly patients with idiopathic interstitial pneumonia (IIP), and to explore their clinical significance. Methods A total of 96 elderly patients with IIP who were treated in our hospital from May 2019 to May 2022 were selected. According to the severity of IIP, the patients were divided into acute exacerbation group (n=62) and stable phase group (n=34). According to the 3-month follow-up of the patients in the acute exacerbation group, they were divided into survival subgroup (n=40) and death subgroup (n=22).Sixty healthy individuals who underwent physical examination during the same period were selected as the control group. Enzyme linked immunosorbent assay was used to detect the serum levels of S100A9 and sCD163.Multivariate Logistic regression analysis was used to investigate the influencing factors of death in the elderly patients with acute exacerbation phase of IIP. The predictive value of serum S100A9 and sCD163 for mortality in the patients with acute exacerbation of IIP was analyzed by receiver operating characteristic (ROC) curve. Results The serum levels of S100A9 and sCD163 in the acute exacerbation group were significantly higher than those in the stable phase group and the control group (all P<0.01).The levels of serum S100A9 and sCD163 in the elderly patients with acute exacerbation phase of IPP were positively correlated with erythrocyte sedimentation rate and high resolution computed tomography (HRCT) score (all P<0.05). Multivariate Logistic regression analysis showed that HRCT scores, the levels of S100A9 and sCD163 were the independent influencing factors for mortality in the elderly patients with acute exacerbation phase of IIP. ROC curve analysis showed that the area under the curve(AUC) of the combination of HRCT score, serum S100A9 and sCD163 in predicting mortality in the elderly patients with acute exacerbation phase of IIP was 0.907, which was higher than that of the single indicator (Z=5.183, 4.349, 5.127, all P<0.05). Conclusions The combination detection of S100A9 and sCD163 has high predictive value for mortality in the elderly patients with acute exacerbation phase of IIP.

Key words: aged, idiopathic interstitial pneumonia, S100 calcium-binding protein A9, soluble CD163, prognosis

CLC Number:

R563.1

WANG Xinping, XIE Baimei, WEI Guo, YE Xiaoli, ZHAO Yayun, TAN Xiaotian. Expression levels and clinical significance of serum S100A9 and sCD163 in elderly patients with idiopathic interstitial pneumonia[J]. Practical Geriatrics, 2024, 38(8): 802-807.

References

[1] TODD N W, ATAMAS S P, HINES S E, et al. Demystifying idiopathic interstitial pneumonia: time for more etiology-focused nomenclature in interstitial lung disease[J]. Expert Rev Respir Med, 2022,16(2):235-245.
[2] GUARNERA A, SANTINI E, PODDA P. Idiopathic interstitial pneumonias and COVID-19 pneumonia: review of the main radiological features and differential diagnosis[J]. Tomography, 2021,7(3):397-411.
[3] MELLOR L F, GAGO-LOPEZ N, BAKIRI L, et al. Keratinocyte-derived S100A9 modulates neutrophil infiltration and affects psoriasis-like skin and joint disease[J]. Ann Rheum Dis, 2022, 81(10):1400-1408.
[4] ARAKI K, KINOSHITA R, TOMONOBU N, et al. The heterodimer S100A8/A9 is a potent therapeutic target for idiopathic pulmonary fibrosis[J]. J Mol Med: Berl, 2021, 99(1):131-145.
[5] BHATTACHARYA M. Insights from transcriptomics: CD163+ profibrotic lung macrophages in COVID-19[J]. Am J Respir Cell Mol Biol, 2022, 67(5):520-527.
[6] YAMASHITA M, UTSUMI Y, NAGASHIMA H, et al. S100A9/CD163 expression profiles in classical monocytes as biomarkers to discriminate idiopathic pulmonary fibrosis from idiopathic nonspecific interstitial pneumonia[J]. Sci Rep, 2021, 11(1):12135-12141.
[7] TRAVIS W D, COSTABEL U, HANSELL D M, et al. An official American Thoracic Society/European Respiratory Society statement:update of the international multidisciplinary classification of the idiopathic interstitial pneumonias[J]. Am J Respir Crit Care Med, 2013,188(6):733-748.
[8] SAMARELLI A V, TONELLI R, MARCHION A, et al. Fibrotic idiopathic interstitial lung disease: the molecular and cellular key players[J]. Int J Mol Sci, 2021,22(16):8952-8966.
[9] 李莉红, 白璐, 王鹏. 急性加重期特发性间质性肺炎患者血清多配体蛋白聚糖4水平变化及其与近期预后的关系研究[J]. 实用心脑肺血管病杂志, 2018,26(12):49-53.
[10] 曾显荣, 弋春燕, 刘庆玲, 等. 寻常型间质性肺炎与非特异性间质性肺炎的临床特点及HRCT表现对比分析[J]. 中国CT和MRI杂志, 2022,20(4):39-42.
[11] MONTEIRO C, MIARKA L, PEREA-GARC M, et al. Stratification of radiosensitive brain metastases based on an actionable S100A9/RAGE resistance mechanism[J]. Nat Med, 2022, 28(4):752-765.
[12] SPRENKELER E G G, ZANDSTRA J, VAN K N D, et al. S100A8/A9 is a marker for the release of neutrophil extracellular traps and induces neutrophil activation[J]. Cells, 2022, 11(2):236-242.
[13] GARCIA V, PERERA Y R, CHAZIN W J. A structural perspective on calprotectin as a ligand of receptors mediating inflammation and potential drug target[J]. Biomolecules, 2022, 12(4):519-525.
[14] KIM R Y, SUNKARA K P, BRACKE K R, et al. A microRNA-21-mediated SATB1/S100A9/NF-κB axis promotes chronic obstructive pulmonary disease pathogenesis[J]. Sci Transl Med, 2021, 13(621): 7223-7230.
[15] ELEFTHERIADIS T, PISSAS G, CRESPO M, et al. The effect of anti-HLA class I antibodies on the immunological properties of human glomerular endothelial cells and their modification by mTOR inhibition or GCN2 kinase activation[J]. Mol Med Rep, 2021,23(5):355-368.
[16] OLALOYE O O, L P, TOOTHAKER J M, et al. CD16+CD163+ monocytes traffic to sites of inflammation during necrotizing enterocolitis in premature infants[J]. J Exp Med, 2021, 218(9):2020-2027.
[17] CUTOLO M, CAMPITIELLO R, GOTELLI E, et al. The role of M1/M2 macrophage polarization in rheumatoid arthritis synovitis[J]. Front Immunol, 2022, 19(13):8672-8680.
[18] LIU B, LI R, ZHANG J, et al. MicroRNA-708-3p as a potential therapeutic target via the ADAM17-GATA/STAT3 axis in idiopathic pulmonary fibrosis[J]. Exp Mol Med, 2018, 50(3):465-473.
[19] CUTOLO M, CAMPITIELLO R, GOTELLI E, et al. The role of M1/M2 macrophage polarization in rheumatoid arthritis synovitis[J]. Front Immunol, 2022, 19(13):8672-8680.
[20] YE Q, DALAVANGA Y, POULAKIS N, et al. Decreased expression of haem oxygenase-1 by alveolar macrophages in idiopathic pulmonary fibrosis[J]. Eur Respir J, 2008, 31(5):1030-1036.
[21] YAMASHITA M, SAITO R, YASUHIRA S,et al. Distinct profiles of CD163-positive macrophages in idiopathic interstitial pneumonias[J]. J Immunol Res, 2018, 20(8):1436-1446.
[22] SAMARELLI A V, TONELLI R, MARCHIONI A, et al. Fibrotic idiopathic interstitial lung disease: the molecular and cellular key players[J]. Int J Mol Sci, 2021, 22(16):8952-8959.
[23] NOUNO T, OKAMOTO M, OHNISHI K, et al. Elevation of pulmonary CD163+ and CD204+ macrophages is associated with the clinical course of idiopathic pulmonary fibrosis patients[J]. J Thorac Dis, 2019, 11(9):4005-4017.

Expression levels and clinical significance of serum S100A9 and sCD163 in elderly patients with idiopathic interstitial pneumonia

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Metrics

Recommended 10

[1]	WANG Xiaojiao, WANG Ning, CUI Hong, YE Tong, WANG Xiaoming. Influence of exercise rehabilitation in elderly patients with mild to moderate chronic heart failure [J]. Practical Geriatrics, 2024, 38(8): 775-778.
[2]	SHEN Chenjun, WANG Xiaoqing, TANG Degang, NING Ping. Correlation between standardized uric acid and renal function in elderly patients with chronic kidney disease aged 90 and over [J]. Practical Geriatrics, 2024, 38(8): 779-782.
[3]	HAO Shijie, ZOU Jianpeng, WEI Chen, LIU Qingjiang. Effect of comprehensive respiratory training on hypokinetic dysarthria in elderly patients with Parkinson’s disease [J]. Practical Geriatrics, 2024, 38(8): 783-787.
[4]	XIANG Chao, LUO Caidong. Analysis of the diagnostic value of T wave change of avL lead for the degree of coronary artery stenosis in elderly patients with coronary heart disease [J]. Practical Geriatrics, 2024, 38(8): 788-791.
[5]	LI Huiying, CAI Lili, ZHU Qiwei. Predictive value of plasma N-terminal pro-brain natriuretic peptide for prognosis in patients aged ≥80 years old with left ventricular hypertrophy [J]. Practical Geriatrics, 2024, 38(8): 797-801.
[6]	LIU Meijuan, WANG Ning, WANG Dong, LU Fangzhou, LIU Juan. Effect of low-dose lidocaine combined with propofol on motor evoked potential in elderly patients undergoing intracranial tumor resection [J]. Practical Geriatrics, 2024, 38(8): 808-811.
[7]	LI Jingbing, WANG Huijun, WANG Shaoying, ZHAO Can, WANG Lidi, CAO Yujiao. Impacts of pentoxifylline combined with lipoic acid intervention on physical function and quality of life in elderly patients with frailty syndrome [J]. Practical Geriatrics, 2024, 38(8): 812-815.
[8]	ZHAO Yuling, HUANG Jing, YE Wenchun. Interaction effects of serum levels of γ-aminobutyric acid and insulin-like growth factor-1 on cardiovascular event risk in elderly patients with prediabetes [J]. Practical Geriatrics, 2024, 38(8): 816-820.
[9]	LAI Xiaoxing, CHEN Baoyu, LIU Xiaoxuan, LI Qi, ZHU Hongwei, HUO Xiaopeng. Effect of motor-cognitive dual task training on cognitive frailty in the elderly [J]. Practical Geriatrics, 2024, 38(8): 821-825.
[10]	LIANG Shanshan, LIANG Huan, YANG Shan, LIU Jianfeng. Relationship between sarcopenia and carotid atherosclerosis in elderly patients with type 2 diabetes mellitus [J]. Practical Geriatrics, 2024, 38(8): 826-830.
[11]	HUANG Rui. Prediction value of GNRI and CONUT score for≥grade 2 radiation pneumonia after radiotherapy in elderly patients with locally advanced non-small cell lung cancer [J]. Practical Geriatrics, 2024, 38(8): 831-836.
[12]	LIU Yubao, WANG Zhen. Effects of different tourniquet release pattern in elderly patients undergoing total knee arthroplasty [J]. Practical Geriatrics, 2024, 38(1): 18-21.
[13]	ZHANG Ming, CHEN Xi, LIU Yuehong, XIE De, WANG Zhicong, LAN Pingwen, WANG Guanglin. Relationship between red blood cell volume distribution width and prognosis of elderly patients with hip fracture [J]. Practical Geriatrics, 2024, 38(1): 22-27.
[14]	ZHAO Xin, YAN Junwei, YIN Zhaowei, SHI Chen, PAN Shaowei, GU Yanqing, XU Chenyang, YANG Wengbo, WANG Xiao, LIANG Bin. Comparison of intramedullary reduction technique and leverage reduction technique combined with locking plate in the treatment of complex proximal humeral fractures in elderly [J]. Practical Geriatrics, 2024, 38(1): 40-43.
[15]	SUN Jie, ZHA Xiufang, XU Jin, ZHAO Junning, HE Wei, ZHANG Nannan. Correlation of AHNAK expression with macrophage infiltration and prognosis in patients with gastric cancer [J]. Practical Geriatrics, 2024, 38(1): 49-53.