Abstract: Objective To explore the correlation between standardized uric acid[serum uric acid (SUA) /serum creatinine(Scr)] and renal function in the elderly patients with chronic kidney disease(CKD) aged ≥90 years old, and to provide reference for the treatment of SUA. Methods The clinical data of the elderly patients with CKD aged ≥ 90 years old at First People’s Hospital of Chuzhou were retrospectively analyzed, including basic information, renal function indicators, medication use. The correlation of SUA and standardized uric acid with renal function indicators were analyzed. Results A total of 82 medical records of 58 patients were enrolled, and there was no significant change in renal function during hospitalization. The levels of SUA and renal function indicators after using uric acid lowering drugs showed no significant differences with those before treatment(P>0.05). Standardized uric acid was negatively correlated with Scr (r=-0.678), urea nitrogen (r=-0.505) and cystatin C (r=-0.611), while positively correlated with estimated glomerular filtration rate(eGFR) (r=0.738, P＜0.01). Conclusions Standardized uric acid has a strong correlation with renal function indicators in the elderly patients with CKD aged ≥ 90 years old. The use of uric acid lowering drugs cannot significantly improve renal function. On the contrary, an increase in standardized uric acid within a certain range may help improve the renal function indicators in these patients.

Key words: aged ≥ 90 years, kidney disease, standardized uric acid, renal function, correlation