Table of Content

20 August 2024, Volume 38 Issue 8 Previous Issue    Next Issue

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Influence of exercise rehabilitation in elderly patients with mild to moderate chronic heart failure WANG Xiaojiao, WANG Ning, CUI Hong, YE Tong, WANG Xiaoming 2024, 38 (8):  775-778.  doi: 10.3969/j.issn.1003-9198.2024.08.005 Abstract ( 110 )   PDF (1396KB) ( 648 )   Save Objective To analyze the effect of exercise rehabilitation in the elderly patients with mild to moderate chronic heart failure(CHF). Methods From January 2020 to December 2022, 104 elderly patients with mild to moderate CHF (New York Heart Association cardiac function classification Ⅱ-Ⅲ grade) were randomly divided into two groups, with 52 cases in each group. The control group was given conventional anti-heart failure therapy, and the observation group was given standardized exercise load rehabilitation guidance based on the conventional anti-heart failure therapy. The changes of cardiac function, sleep quality, exercise tolerance, quality of life and the incidence rate of cardiovascular adverse events were observed and compared 6 months after discharge. Results The levels of left ventricular ejection fraction (LVEF), cardiac output (CO) and stroke volume (SV), the score of Minnesota Living with heart failure questionnaire (MLHFQ) and the 6-minute walk distance (6MWD) were significantly higher, while the score of Pittsburgh Sleep Quality Inventory (PSQI) and the incidence of adverse events 6 months after discharge were significantly lower in the observation group than those in the control group(P<0.05). The treadmill exercise time in the observation group was longer than that in the control group. With the extension of treadmill exercise time, acceleration of speed and increase of slope, the heart rate in the two groups was significantly increased, especially in the control group (P<0.05). Conclusions Standardized exercise load rehabilitation guidance can improve exercise tolerance and sleep quality of the elderly patients with mild to moderate CHF, which is worthy of clinical promotion. References | Related Articles | Metrics

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Correlation between standardized uric acid and renal function in elderly patients with chronic kidney disease aged 90 and over SHEN Chenjun, WANG Xiaoqing, TANG Degang, NING Ping 2024, 38 (8):  779-782.  doi: 10.3969/j.issn.1003-9198.2024.08.006 Abstract ( 102 )   PDF (1059KB) ( 361 )   Save Objective To explore the correlation between standardized uric acid[serum uric acid (SUA) /serum creatinine(Scr)] and renal function in the elderly patients with chronic kidney disease(CKD) aged ≥90 years old, and to provide reference for the treatment of SUA. Methods The clinical data of the elderly patients with CKD aged ≥ 90 years old at First People’s Hospital of Chuzhou were retrospectively analyzed, including basic information, renal function indicators, medication use. The correlation of SUA and standardized uric acid with renal function indicators were analyzed. Results A total of 82 medical records of 58 patients were enrolled, and there was no significant change in renal function during hospitalization. The levels of SUA and renal function indicators after using uric acid lowering drugs showed no significant differences with those before treatment(P>0.05). Standardized uric acid was negatively correlated with Scr (r=-0.678), urea nitrogen (r=-0.505) and cystatin C (r=-0.611), while positively correlated with estimated glomerular filtration rate(eGFR) (r=0.738, P＜0.01). Conclusions Standardized uric acid has a strong correlation with renal function indicators in the elderly patients with CKD aged ≥ 90 years old. The use of uric acid lowering drugs cannot significantly improve renal function. On the contrary, an increase in standardized uric acid within a certain range may help improve the renal function indicators in these patients. References | Related Articles | Metrics

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Effect of comprehensive respiratory training on hypokinetic dysarthria in elderly patients with Parkinson’s disease HAO Shijie, ZOU Jianpeng, WEI Chen, LIU Qingjiang 2024, 38 (8):  783-787.  doi: 10.3969/j.issn.1003-9198.2024.08.007 Abstract ( 83 )   PDF (1102KB) ( 314 )   Save Objective To observe the effect of comprehensive respiratory training on hypokinetic dysarthria in the elderly patients with Parkinson’s disease. Methods A total of 48 patients with Parkinson’s disease who were enrolled according to inclusion and exclusion criteria were randomly divided into the control group and the treatment group, with 24 patients in each group. The control group received basic articulation training, while the treatment group received comprehensive respiratory training on the basis of the control group. Two groups were treated for four weeks, and the changes in Frenchay Dysarthria Assessment(FDA) score, maximum phonation time(MPT), diadochokinesia rate(DR) of different syllables and maximum inspiratory pressure(MIP) were observed before and after treatment. Results Before treatment, there were no statistical differences in FDA score, MPT, DR of different syllables and MIP between the two groups (P>0.05).After treatment, FDA score, MPT and DR of different syllable in the two groups were significantly higher than those before treatment (P<0.01), and FDA score, MPT, DR of different syllable and MIP levels in the treatment group were higher than those in the control group (P<0.05 or P<0.01). Conclusions Comprehensive respiratory training can promote coordination of breathing and vocalization, and improve hypokinetic dysarthria in the elderly patients with Parkinson’s disease. References | Related Articles | Metrics

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Analysis of the diagnostic value of T wave change of avL lead for the degree of coronary artery stenosis in elderly patients with coronary heart disease XIANG Chao, LUO Caidong 2024, 38 (8):  788-791.  doi: 10.3969/j.issn.1003-9198.2024.08.008 Abstract ( 83 )   PDF (1107KB) ( 327 )   Save Objective To analyze the diagnostic value of T wave change of avL lead in electrocardiograph(ECG) for the degree of coronary artery stenosis in the elderly patients with coronary heart disease (CHD). Methods A total of 124 elderly patients with CHD who were treated in our hospital from July 2019 to October 2022 were selected and divided into severe group (Gensini score > 40,36 cases), moderate group (Gensini score 21-40,40 cases) and mild group (Gensini score 1-20,48 cases). All patients received ECG detection. The general data, laboratory indexes, avL lead T wave changes and other ECG characteristics of the three groups were observed and compared. The risk factors of the degree of coronary artery stenosis in the elderly CHD patients were analyzed by Logistic regression analysis. Receiver operating characteristic (ROC) curve was drawn to analyze the value of avL lead T wave changes in the diagnosis of coronary artery stenosis in the elderly CHD patients. Results The levels of left ventricular end-diastolic diameter (LVEDD) and serum N-terminal pro-brain natriuretic peptide (NT-proBNP) were highest in the severe group, followed by the moderate group and the mild group (P<0.05).There were significant differences in the proportions of T wave changes in avL lead, ST-segment elevation, ST-segment depression and pathological Q wave among the three groups (P<0.01). Logistic regression analysis showed that NT-proBNP, LVEDD, T wave changes in avL lead, ST-segment elevation, ST-segment depression and pathological Q wave were the independent risk factors for the degree of coronary artery stenosis in the elderly patients with CHD; ROC curve showed that the area under the curve (AUC)of T wave changes in avL lead in diagnosing coronary artery stenosis in the elderly patients with CHD was 0.701 (95%CI: 0.603-0.798). Conclusions The T wave changes of avL lead in ECG is an independent risk factor for the degree of coronary artery stenosis in the elderly CHD patients, and it has certain value in the diagnosis of coronary artery stenosis. References | Related Articles | Metrics

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Feasibility and application value of free-breathing coronary CT angiography using 320-MDCT in elderly patients WANG Xuan, TANG Wuliang, SHAO Hailei, XU Qiuzhen 2024, 38 (8):  792-796.  doi: 10.3969/j.issn.1003-9198.2024.08.009 Abstract ( 81 )   PDF (1948KB) ( 421 )   Save Objective To explore the feasibility and application value of 320-Multi-Detector CT(320-MDCT) for free-breathing coronary CT angiography (CCTA) in the elderly patients. Methods A total of 100 elderly patients who underwent CCTA scanning using 320-MDCT at Zhongda Hospital Southeast University from October 2022 to May 2023 were selected retrospectively. The patients were divided into free-breathing group (n=50) and breath-holding group (n=50) based on their respiratory status during the scan. The CT values, signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR) of the aorta, right coronary artery (RCA) and left main coronary artery (LM) and effective dose (ED), standard deviation (SD) of pericoronal adipose tissue in the two sets of images were measured and compared. Two physicians used a 4-point method to perform a double-blind evaluation of the image quality of 15 coronary segments in the two groups, and Mann-Whitney U test was used to evaluate the subjective ratings. Kappa test was used to assess inter-rater agreement of the two physicians. Results The differences in CT values, SNR and CNR of aorta, RCA and LM between the two groups were not statistically significant (P>0.05).There was no significant difference in subjective scores between the two groups and the same results were observed in the high heart rate group (>75 bpm) and the medium-low heart rate group (≤75 bpm) (P >0.05). The consistency of subjective scores between the two physicians was good (kappa values were 0.633 and 0.720), and the level of ED in the free-breathing group was lower than that in the breath-holding group (P <0.05). Conclusions Free-breathing CCTA may be feasible on 320-MDCT with high image quality and low radiation dose in the elderly patients. References | Related Articles | Metrics

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Predictive value of plasma N-terminal pro-brain natriuretic peptide for prognosis in patients aged ≥80 years old with left ventricular hypertrophy LI Huiying, CAI Lili, ZHU Qiwei 2024, 38 (8):  797-801.  doi: 10.3969/j.issn.1003-9198.2024.08.010 Abstract ( 77 )   PDF (1089KB) ( 516 )   Save Objective To explore the predictive value of N-terminal pro-brain natriuretic peptide (NT-proBNP) for the prognosis in the elderly patients aged≥80 years old with left ventricular hypertrophy(LVH). Methods A total of 309 elderly patients aged ≥80 years old with LVH admitted to the Second Medical Center of the General Hospital of the People’s Liberation Army were enrolled in the study. The clinical baseline data, biochemistry index and the plasma level of NT-proBNP were collected. All-cause death and major adverse cardiovascular events (MACEs) of the patients were followed up. Linear regression was used to screen the clinical factors related to NT-proBNP. Cox risk proportional regression model was used to evaluate the relationship between NT-proBNP level and endpoint events. Receiver operating characteristic (ROC) curve wad used to evaluate the predictive value of NT-proBNP for the prognosis in the elderly patients with LVH. Results The median NT-proBNP level of 309 patients was 325 (144,821) pg/mL. The plasma level of NT-proBNP was positively correlated with aging, atrial fibrillation, pacemaker implantation, left ventricular mass index (LVMI) and the use of β-blockers, while negatively correlated with estimated glomerular filtration rate (eGFR), hemoglobin, plasma albumin and left ventricular ejection fraction(LVEF). A median follow-up of 6.7 (3.1,9.1) years showed 239(77.3%) cases of death and 117(37.9%) cases of MACEs. The multivariate Cox regression model showed that the highest percentile group of NT-proBNP had a significantly increased risk of all-cause death (HR= 3.029; 95% CI: 1.918-4.728) and MACEs (HR =3.173; 95% CI: 1.612-6.244) compared to the lowest percentile group. ROC curve analysis showed that the AUC of NT-proBNP in predicting all-cause death and MACEs was 0.669 and 0.594 respectively(P<0.01). Conclusions Plasma NT-proBNP has independent predictive value for all-cause death and MACEs in the elderly patients aged≥80 years old with LVH. References | Related Articles | Metrics

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Expression levels and clinical significance of serum S100A9 and sCD163 in elderly patients with idiopathic interstitial pneumonia WANG Xinping, XIE Baimei, WEI Guo, YE Xiaoli, ZHAO Yayun, TAN Xiaotian 2024, 38 (8):  802-807.  doi: 10.3969/j.issn.1003-9198.2024.08.011 Abstract ( 69 )   PDF (1326KB) ( 329 )   Save Objective To study the levels of serum S100 calcium binding protein A9 (S100A9) and soluble CD163 (sCD163) in the elderly patients with idiopathic interstitial pneumonia (IIP), and to explore their clinical significance. Methods A total of 96 elderly patients with IIP who were treated in our hospital from May 2019 to May 2022 were selected. According to the severity of IIP, the patients were divided into acute exacerbation group (n=62) and stable phase group (n=34). According to the 3-month follow-up of the patients in the acute exacerbation group, they were divided into survival subgroup (n=40) and death subgroup (n=22).Sixty healthy individuals who underwent physical examination during the same period were selected as the control group. Enzyme linked immunosorbent assay was used to detect the serum levels of S100A9 and sCD163.Multivariate Logistic regression analysis was used to investigate the influencing factors of death in the elderly patients with acute exacerbation phase of IIP. The predictive value of serum S100A9 and sCD163 for mortality in the patients with acute exacerbation of IIP was analyzed by receiver operating characteristic (ROC) curve. Results The serum levels of S100A9 and sCD163 in the acute exacerbation group were significantly higher than those in the stable phase group and the control group (all P<0.01).The levels of serum S100A9 and sCD163 in the elderly patients with acute exacerbation phase of IPP were positively correlated with erythrocyte sedimentation rate and high resolution computed tomography (HRCT) score (all P<0.05). Multivariate Logistic regression analysis showed that HRCT scores, the levels of S100A9 and sCD163 were the independent influencing factors for mortality in the elderly patients with acute exacerbation phase of IIP. ROC curve analysis showed that the area under the curve(AUC) of the combination of HRCT score, serum S100A9 and sCD163 in predicting mortality in the elderly patients with acute exacerbation phase of IIP was 0.907, which was higher than that of the single indicator (Z=5.183, 4.349, 5.127, all P<0.05). Conclusions The combination detection of S100A9 and sCD163 has high predictive value for mortality in the elderly patients with acute exacerbation phase of IIP. References | Related Articles | Metrics

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Effect of low-dose lidocaine combined with propofol on motor evoked potential in elderly patients undergoing intracranial tumor resection LIU Meijuan, WANG Ning, WANG Dong, LU Fangzhou, LIU Juan 2024, 38 (8):  808-811.  doi: 10.3969/j.issn.1003-9198.2024.08.012 Abstract ( 78 )   PDF (1100KB) ( 504 )   Save Objective To investigate the effect of low-dose lidocaine combined with propofol on motor evoked potential(MEP) in the elderly patients undergoing intracranial tumor resection. Methods A total of 44 elderly patients receiving intracranial tumor resection monitored by MEP under general anesthesia were enrolled in this study, and were divided into lidocaine group (group L) and control group (group C) by random number table method, with 22 cases in each group.All patients were anesthetized with propofol. The patients in group L received low-dose lidocaine additionally, while the patients in group C was given equal amount of normal saline. The mean arterial pressure(MAP), heart rate(HR), depth of anesthesia, MEP amplitude and latency, propofol dosage and the occurrence of adverse reactions were recorded and compared between the two groups at different time during anesthesia. Results The levels of HR and MAP at different time showed statistically significant differences in group C (P<0.05), while showing no significant differences in group L(P>0.05). During anesthesia, there were no significant differences in MEP amplitude and latency between the two groups (P>0.05), but the dosage of propofol and the incidence rate of adverse reactions in group L were significantly lower than those in group C (P<0.05). Conclusions Low-dose lidocaine has no significant effect on the amplitude and latency of MEP in the elderly patients undergoing surgery for intracranial tumor, which is conductive to maintain hemodynamic stability, reduce intraoperative propofol dosage and the incidence of adverse reactions. References | Related Articles | Metrics

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Impacts of pentoxifylline combined with lipoic acid intervention on physical function and quality of life in elderly patients with frailty syndrome LI Jingbing, WANG Huijun, WANG Shaoying, ZHAO Can, WANG Lidi, CAO Yujiao 2024, 38 (8):  812-815.  doi: 10.3969/j.issn.1003-9198.2024.08.013 Abstract ( 92 )   PDF (1057KB) ( 424 )   Save Objective To analyze the impacts of pentoxifylline combined with lipoic acid on physical function and quality of life in the elderly patients with frailty syndrome. Methods A total of 120 elderly patients with frailty syndrome admitted into our hospital from February 2020 to February 2022 were enrolled in this study, and all patients were divided to the single-drug group (n=60) and the combination group (n=60) according to random number table method. The single-drug group was treated with lipoic acid, and the combination group was given lipoic acid combined with pentoxifylline. The frailty was assessed by the Clinical Frailty Scale (Fried). The physical function was evaluated by Tinetti-Balance and Gait Scale (Tinetti-POMA) and the activities of daily living (ADL) scale, and the quality of life was assessed by MOS 36-Item Short Form Health Survey (SF-36).The efficacy, grip strength and pace speed before and after the intervention, and the incidence rate of adverse effects were observed and compared between the two groups. Results After the intervention, the Fried score was significantly decreased, and the grip strength, pace speed, scores of Tinetti-POMA, ADL scale and SF-36 were significantly increased in the two group, especially in the combination group (P<0.05). The safety indexes before and after treatment were all within the range of clinical normal values in the two groups, and there was no statistical difference in the incidence rate of adverse reactions between the two groups (P>0.05). Conclusions Pentoxifylline combined with lipoic acid can effectively and safely improve the physical function and quality of life of the elderly patients with frailty syndrome. References | Related Articles | Metrics

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Interaction effects of serum levels of γ-aminobutyric acid and insulin-like growth factor-1 on cardiovascular event risk in elderly patients with prediabetes ZHAO Yuling, HUANG Jing, YE Wenchun 2024, 38 (8):  816-820.  doi: 10.3969/j.issn.1003-9198.2024.08.014 Abstract ( 77 )   PDF (1284KB) ( 289 )   Save Objective To explore the interaction effects of serum levels of γ-aminobutyric acid(GABA) and insulin-like growth factor-1(IGF-1) on cardiovascular event risk in the elderly patients with prediabetes. Methods A total of 100 patients with prediabetes in our hospital from January 2020 to January 2023 were selected as the control group, and 100 patients with prediabetes complicated with cardiovascular events during the same period were selected as the observation group. The serum levels of GABA and IGF-1 in the two groups were detected. Binary Logistic model was used to analyze the influencing factors of cardiovascular events in the elderly patients with prediabetes. The restricted cubic spline method was used to analyze the intensity of association between GABA, IGF-1 and cardiovascular events in the elderly patients with prediabetes. The interaction of GABA and IGF-1 on cardiovascular events in prediabetic patients was analyzed by relative excess risk due to interaction (RERI), attributable proportion to the interaction (AP) and synergy index (S). Results Age, the levels of systolic blood pressure (SBP), fasting plasma glucose (FPG), 2-hour postprandial plasma glucose (2hPG), total cholesterol (TC), triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C) were significantly higher and the levels of high-density lipoprotein cholesterol (HDL-C), GABA and IGF-1 were lower in the observation group than those in the control group (P<0.05). Binary Logistic regression analysis showed that SBP, FPG and LDL-C were the risk factors, while GABA and IGF-1 were the protective factors for cardiovascular events in the elderly patients with prediabetes (P<0.05).The continuous changes of GABA and IGF-1 were negatively correlated with the strength of association of cardiovascular events, and the risk of cardiovascular events in prediabetic patients was lowest when the level of GABA was > 5.00 μmol/L and the level of IGF-1 was >119 ng/mL. Both high expression of GABA and IGF-1 were as common reference, and after adjusting age, SBP, FPG, TC, TG, LDL-C and HDL-C, low expression of GABA and IGF-1 had a positive interaction on the occurrence of cardiovascular events in prediabetic patients. The synergistic effect was 2.760 times of the summation of the effects of GABA and IGF-1 alone (S=2.760). In the total risk of cardiovascular events in prediabetic individuals, the interaction of low expression of GABA and IGF-1 accounted for 60.43% (API=60.43%). Conclusions GABA and IGF-1 are independent protective factors of cardiovascular events in the patients with prediabetes, and they play a synergistic role in the occurrence of cardiovascular events in the elderly patients with prediabetes. When the expression of GABA and IGF-1 is reduced, the risk of cardiovascular events should be considered. References | Related Articles | Metrics

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Effect of motor-cognitive dual task training on cognitive frailty in the elderly LAI Xiaoxing, CHEN Baoyu, LIU Xiaoxuan, LI Qi, ZHU Hongwei, HUO Xiaopeng 2024, 38 (8):  821-825.  doi: 10.3969/j.issn.1003-9198.2024.08.015 Abstract ( 104 )   PDF (1085KB) ( 371 )   Save Objective To explore the effect of motor-cognitive dual task training in the elderly patients with cognitive frailty. Methods A total of 72 elderly people with cognitive frailty meeting the inclusion criteria were enrolled and randomly divided into intervention group and control group, with 36 cases in each group. The control group was given health education about cognitive frailty, while the intervention group received motor-cognitive dual task training for 16 weeks in addition. The frailty status, cognitive and motor function before and after intervention in the two groups were assessed and compared. Results Before intervention, there were no significant differences in the general information, scores of Tilburg frailty indicator (TFI), Montreal Cognitive Assessment(MoCA), Performance Oriented Mobility Assessment (POMA)and time up and go test(TUGT) between the two groups(P>0.05). After intervention, the score of TFI and the time of TUGT were significantly lower and the scores of MoCA and POMA were significantly higher in intervention group than those in control group (P<0.05). Conclusions Motor-cognitive dual task training can effectively improve the frailty, cognitive and physical function of the elderly with cognitive frailty, and it is suitable to popularize in the elderly with cognitive frailty. References | Related Articles | Metrics

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Relationship between sarcopenia and carotid atherosclerosis in elderly patients with type 2 diabetes mellitus LIANG Shanshan, LIANG Huan, YANG Shan, LIU Jianfeng 2024, 38 (8):  826-830.  doi: 10.3969/j.issn.1003-9198.2024.08.016 Abstract ( 90 )   PDF (1072KB) ( 437 )   Save Objective To analyze the correlation between sarcopenia and carotid atherosclerosis in the elderly patients with type 2 diabetes mellitus(T2DM). Methods The clinical data of 97 elderly patients with T2DM admitted to our hospital from April 2021 to April 2023 were collected retrospectively. According to the skeletal muscle mass index (ASMI), the patients were divided into the sarcopenia group (41 cases) and the non-sarcopenia group (56 cases).The clinical data and carotid ultrasound indicators were collected and compared between the two groups. The risk factors affecting the occurrence of sarcopenia in the elderly patients with T2DM were analyzed. Results The levels of body mass index (BMI), T value of bone density, homextasis model assessment-insulin resitance (HOMA-IR), uric acid and ASMI in the sarcopenia group were significantly lower than those in the non-sarcopenia group (P<0.05).The number of carotid plaques, the Crouse score, semi-quantitative score, and grade score, carotid intima-media thickness (cIMT) were higher in the sarcopenia group than those in the non-sarcopenia group (P<0.05).The main grade of carotid atherosclerosis was grade 3 in the sarcopenia group, compared with grade 0 or 1 in the non-sarcopenia group, and the proportion of the two groups was significantly different (P<0.01).Logistic regression analysis showed that BMI, number of carotid plaque, cIMT, Crouse score, semi-quantitative score and grade score were risk factors for sarcopenia in the elderly patients with T2DM (P<0.05). Conclusions There is a certain correlation between sarcopenia and carotid atherosclerosis in the elderly patients with T2DM. Preventive measures should be actively taken to improve the progress of disease. References | Related Articles | Metrics

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Prediction value of GNRI and CONUT score for≥grade 2 radiation pneumonia after radiotherapy in elderly patients with locally advanced non-small cell lung cancer HUANG Rui 2024, 38 (8):  831-836.  doi: 10.3969/j.issn.1003-9198.2024.08.017 Abstract ( 77 )   PDF (1325KB) ( 294 )   Save Objective To analyze the predictive value of geriatric nutritional risk index (GNRI) and controlling nutritional status (CONUT) score for ≥grade 2 radiation pneumonia (RP) after radiotherapy in the elderly patients with locally advanced non-small cell lung cancer (NSCLC). Methods A total of 81 elderly patients with stage Ⅲ NSCLC aged ≥65 years who received radiotherapy in our hospital from January 2019 to January 2022 were enrolled in this study, and they were followed up for 3 months after radiotherapy. According to the occurrence of RP, the patients were divided into ≥grade 2 RP group (group A,25 cases) and ＜grade 2 group (group B,56 cases). The clinical data and radiotherapy dosimetry parameters of the patients were collected. GNRI and CONUT scores at the end of radiotherapy were evaluated and compared between the two groups. Multivariate Logistic regression analysis was used to explore the influencing factors of ≥grade 2 RP after radiotherapy, and receiver operating characteristic(ROC)curve was used to analyze the predictive value of GNRI and CONUT scores for ≥grade 2 RP after radiotherapy in the elderly patients with locally advanced NSCLC. Results The dosimetry comparison between the two groups showed that V20 (percentage of lung volume receiving radiation dose ＞20 Gy in both lungs) in group A was higher than that in group B (P < 0.05). At the end of radiotherapy, GNRI was lower while the CONUT score was higher in group A than that in group B (P < 0.05) . Multivariate Logistic regression showed that low GNRI and high CONUT score at the end of radiotherapy were independent risk factors for ≥grade 2 RP after radiotherapy in the elderly patients with locally advanced NSCLC. ROC curve analysis showed that the cut-off value of GNRI and CONUT score in predicting ≥grade 2 RP after radiotherapy was 94.22 and 4.5, with an area under the curve(AUC) of 0.785 and 0.894 respectively. The AUC of the combination of GNRI and CONUT score in predicting ≥grade 2 RP after radiotherapy was 0.925, and the sensitivity was 0.840, and the specificity was 0.929. Conclusions Low GNRI and high CONUT score at the end of radiotherapy are independent risk factors for ≥grade 2 RP after radiotherapy in the elderly patients with locally advanced NSCLC, and combination of GNRI and CONUT score have high predictive value. References | Related Articles | Metrics