血浆N末端脑钠肽前体对高龄左室肥厚病人预后的预测价值

doi:10.3969/j.issn.1003-9198.2024.08.010

Abstract

Abstract: Objective To explore the predictive value of N-terminal pro-brain natriuretic peptide (NT-proBNP) for the prognosis in the elderly patients aged≥80 years old with left ventricular hypertrophy(LVH). Methods A total of 309 elderly patients aged ≥80 years old with LVH admitted to the Second Medical Center of the General Hospital of the People’s Liberation Army were enrolled in the study. The clinical baseline data, biochemistry index and the plasma level of NT-proBNP were collected. All-cause death and major adverse cardiovascular events (MACEs) of the patients were followed up. Linear regression was used to screen the clinical factors related to NT-proBNP. Cox risk proportional regression model was used to evaluate the relationship between NT-proBNP level and endpoint events. Receiver operating characteristic (ROC) curve wad used to evaluate the predictive value of NT-proBNP for the prognosis in the elderly patients with LVH. Results The median NT-proBNP level of 309 patients was 325 (144,821) pg/mL. The plasma level of NT-proBNP was positively correlated with aging, atrial fibrillation, pacemaker implantation, left ventricular mass index (LVMI) and the use of β-blockers, while negatively correlated with estimated glomerular filtration rate (eGFR), hemoglobin, plasma albumin and left ventricular ejection fraction(LVEF). A median follow-up of 6.7 (3.1,9.1) years showed 239(77.3%) cases of death and 117(37.9%) cases of MACEs. The multivariate Cox regression model showed that the highest percentile group of NT-proBNP had a significantly increased risk of all-cause death (HR= 3.029; 95% CI: 1.918-4.728) and MACEs (HR =3.173; 95% CI: 1.612-6.244) compared to the lowest percentile group. ROC curve analysis showed that the AUC of NT-proBNP in predicting all-cause death and MACEs was 0.669 and 0.594 respectively(P<0.01). Conclusions Plasma NT-proBNP has independent predictive value for all-cause death and MACEs in the elderly patients aged≥80 years old with LVH.

Key words: left ventricular hypertrophy, aged, N-terminal pro-brain natriuretic peptide, major adverse cardiovascular events, all-cause death

CLC Number:

R541

LI Huiying, CAI Lili, ZHU Qiwei. Predictive value of plasma N-terminal pro-brain natriuretic peptide for prognosis in patients aged ≥80 years old with left ventricular hypertrophy[J]. Practical Geriatrics, 2024, 38(8): 797-801.

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Predictive value of plasma N-terminal pro-brain natriuretic peptide for prognosis in patients aged ≥80 years old with left ventricular hypertrophy

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