小剂量利多卡因复合丙泊酚对颅内肿瘤切除老年病人运动诱发电位的影响

doi:10.3969/j.issn.1003-9198.2024.08.012

Abstract

Abstract: Objective To investigate the effect of low-dose lidocaine combined with propofol on motor evoked potential(MEP) in the elderly patients undergoing intracranial tumor resection. Methods A total of 44 elderly patients receiving intracranial tumor resection monitored by MEP under general anesthesia were enrolled in this study, and were divided into lidocaine group (group L) and control group (group C) by random number table method, with 22 cases in each group.All patients were anesthetized with propofol. The patients in group L received low-dose lidocaine additionally, while the patients in group C was given equal amount of normal saline. The mean arterial pressure(MAP), heart rate(HR), depth of anesthesia, MEP amplitude and latency, propofol dosage and the occurrence of adverse reactions were recorded and compared between the two groups at different time during anesthesia. Results The levels of HR and MAP at different time showed statistically significant differences in group C (P<0.05), while showing no significant differences in group L(P>0.05). During anesthesia, there were no significant differences in MEP amplitude and latency between the two groups (P>0.05), but the dosage of propofol and the incidence rate of adverse reactions in group L were significantly lower than those in group C (P<0.05). Conclusions Low-dose lidocaine has no significant effect on the amplitude and latency of MEP in the elderly patients undergoing surgery for intracranial tumor, which is conductive to maintain hemodynamic stability, reduce intraoperative propofol dosage and the incidence of adverse reactions.

Key words: lidocaine, propofol, aged, intracranial tumors, transcranial electrical stimulation, motor evoked potential

CLC Number:

R614
R739.41

LIU Meijuan, WANG Ning, WANG Dong, LU Fangzhou, LIU Juan. Effect of low-dose lidocaine combined with propofol on motor evoked potential in elderly patients undergoing intracranial tumor resection[J]. Practical Geriatrics, 2024, 38(8): 808-811.

References

[1] 高娜, 赵博, 杨晨, 等.右美托咪定混合罗哌卡因头皮神经阻滞在老年患者开颅手术中的应用[J].中国老年学杂志, 2021, 41(3):529-532.
[2] DEANGELIS L M.Global consequences of malignant CNS tumours: a call to action[J].Lancet Neurol, 2019, 18(4): 324-325.
[3] 刘力, 宋伟正.老年颅内肿瘤术中并发非手术区域血肿的危险因素分析[J].现代肿瘤医学, 2019, 27(10): 1724-1727.
[4] 洪健, 韩璐, 陈步东, 等.面神经运动诱发电位监测对听神经瘤术后面神经功能的预测作用[J]. 中华医学杂志, 2020, 100(16):1245-1248.
[5] WALKER C T, KIM H J, PARK P, et al. Neuroanesthesia guidelines for optimizing transcranial motor evoked potential neuromonitoring during deformity and complex spinal surgery: a delphi consensus study[J]. Spine, 2020, 45(13): 911-920.
[6] SINGH S, CHOUHAN R S, BINDRA A, et al. Comparison of effect of dexmedetomidine and lidocaine on intracranial and systemic hemodynamic response to chest physiotherapy and tracheal suctioning in patients with severe traumatic brain injury[J]. J Anesth, 2018, 32(4):518-523.
[7] SLOAN T B, MONGAN P, LYDA C, et al. Lidocaine infusion adjunct to total intravenous anesthesia reduces the total dose of propofol during intraoperative neurophysiological monitoring[J]. J Clin Monit Comput, 2014, 28(2): 139-147.
[8] 聂金凤, 伍谷, 刘强, 等.顺式阿曲库铵对颅内肿瘤切除术病人运动诱发电位的影响[J].中国临床神经外科杂志,2020,25(8):506-509.
[9] 姚越, 余琼, 梁伟民.神经外科手术中运动诱发电位监测及其影响因素的研究进展[J].中国临床神经科学, 2020, 20(8): 110-114.
[10] VELAYUTHAM P, CHERIAN V T, RAJSHEKHAR V,et al. The effects of propofol and isoflurane on intraoperative motor evoked potentials during spinal cord tumour removal surgery-a prospective randomised trial[J]. Indian J Anaesth, 2019, 63(2): 92-99.
[11] 曹静,梁治,刘进德,等.不同剂量顺式阿曲库铵对颅内动脉瘤夹闭术患者运动诱发电位监测的影响[J].中华麻醉学杂志,2020,40(2):213-216.
[12] 赵艾华, 冯立.顺式阿曲库铵的临床药理学研究进展[J].河北医药, 2015, 37(2):253-255.
[13] DEGUCHI H, FURUTANI K, MITSUMA Y, et al. Propofol reduces the amplitude of transcranial electrical motor-evoked potential without affecting spinal motor neurons: a prospective, single-arm, interventional study[J]. J Anesth, 2021, 35(3): 434-441.
[14] URBAN M K, FIELDS K, DONEGAN S W, et al. A randomized crossover study of the effects of lidocaine on motor- and sensory-evoked potentials during spinal surgery[J]. Spine J, 2017, 17(12):1889-1896.
[15] 赵楠溪,曹学照,王俊,等.利多卡因持续静脉输注对腹腔镜结直肠手术患者术后疼痛的影响[J].中国医科大学学报,2019,48(2):136-139.
[16] 石薇,任益锋,余海.围术期静脉输注利多卡因在胸科手术中的应用进展[J].中国胸心血管外科临床杂志,2020,27(5):579-583..
[17] NIGUSSIE E, AREGAWI A, ABRAR M, et al. Lidocaine versus propofol administration on the attenuation of hemodynamic responses during extubation in the adult elective surgical patient: A prospective cohort[J]. Heliyon, 2021, 7(8):e07737.
[18] ZOU Y, KONG G, WEI L,et al. The effect of intravenous lidocaine on hemodynamic response to endotracheal intubation during sufentanil-based induction of anaesthesia[J]. Anaesthesiol Intensive Ther, 2020, 52(4):287-291.

Effect of low-dose lidocaine combined with propofol on motor evoked potential in elderly patients undergoing intracranial tumor resection

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