阿尔茨海默病病人吞咽功能、营养状态与认知功能的相关性研究

doi:10.3969/j.issn.1003-9198.2024.06.009

Abstract

Abstract: Objective To investigate the relationship between swallowing function,nutritional status and cognitive function in the elderly patients with Alzheimer’s disease (AD). Methods A total of 56 elderly patients with AD hospitalized in Department of Geriatrics of the First Affiliated Hospital of Nanjing Medical University (AD group) and 60 normal elderly matched for gender, age from October 2019 to November 2021 (control group) were enrolled in this study. The data of the laboratory indexes including total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), fasting plasma glucose (FPG), uric acid (UA), albumin and hemoglobin (Hb) were collected and compared between the two groups. Two groups underwent the assessment of short-form micronutrient assessment (MNA-SF), Water Swallowing Test, Swallowing Disorder Scale and The Mini-Mental State Examination (MMSE) scale. The relationship of cognitive function with swallowing function and nutritional status in the elderly AD patients was explored. Results The levels of Hb, albumin and the MNA-SF score in AD group were significantly lower than those in control group (P<0.05). The nutritional status of AD patients decreased with the increase of the degree of swallowing disorder (P<0.05). Spearman correlation analysis showed that there was a positive correlation between MMSE score and MNA-SF score (r=0.554, P<0.05). Conclusions The swallowing function and nutritional status of the elderly AD patients are significantly decreased, and there is a positive correlation between the nutritional status and the cognitive function in the elderly AD patients. In clinical work, we should strengthen the screening of the swallowing function, enhance the nutritional support, and actively improve the cognitive function and living conditions of the elderly AD patients.

Key words: Alzheimer’s disease, dysphagia, cognition impairment, malnutrition

CLC Number:

R749.16

LI Qingyang, WANG Chanjuan, WANG Zheng. Study on the correlation of cognitive function with swallowing function and nutritional status in the elderly patients with Alzheimer’s disease[J]. Practical Geriatrics, 2024, 38(6): 577-581.

References

[1] OZBEN T, OZBEN S. Neuro-inflammation and anti-inflammatory treatment options for Alzheimer’s disease[J]. Clin Biochem, 2019,72: 87-89.
[2] BREIJYEH Z, KARAMAN R. Comprehensive review on Alzheimer’s disease: causes and treatment[J]. Molecules, 2020,25(24): 5789.
[3] SERÓN-ARBELOA C, LABARTA-MONZÓN L, PUZO-FONCILLAS J, et al. Malnutrition screening and assessment[J]. Nutrients, 2022,14(12): 2392.
[4] BOCCARDI V, RUGGIERO C, PATRITI A, et al. Diagnostic assessment and management of dysphagia in patients with Alzheimer’s disease[J]. J Alzheimers Dis, 2016,50(4): 947-955.
[5] SIMOES A, OLIVA F A, HEBLING E. Signs for early detection of dysphagia in older adults with severe Alzheimer’s disease[J]. J Nutr Health Aging, 2020,24(6): 659-664.
[6] 刘立明, 瓮长水, 贾建军, 等. 3种吞咽障碍评定量表在老年吞咽障碍患者中的反应性[J]. 中国康复理论与实践, 2010,16(3): 260-261.
[7] 周维金, 何静杰, 崔利华. 脑卒中吞咽障碍的评定与康复治疗[J]. 现代康复, 1999,3(11): 1329-1331.
[8] 张彩华, 朱宏霞, 徐奕. 微型营养评价精法用于老年痴呆病人营养状况的评价[J]. 护理研究, 2009,23(25): 2305-2306.
[9] 孙强,吴波,茆梦,等. 主观认知下降对术后谵妄的预测价值[J]. 实用老年医学, 2023,37(2): 156-159.
[10] BRIGGS R, KENNELLY S P, O’NEILL D. Drug treatments in Alzheimer’s disease[J]. Clin Med: Lond, 2016,16(3): 247-253.
[11] PAYETTE H, COULOMBE C, BOUTIER V, et al. Nutrition risk factors for institutionalization in a free-living functionally dependent elderly population[J]. J Clin Epidemiol, 2000,53(6): 579-587.
[12] KIMURA A, SUGIMOTO T, KITAMORI K, et al. Malnutrition is associated with behavioral and psychiatric symptoms of dementia in older women with mild cognitive impairment and early-stage Alzheimer’s disease[J]. Nutrients, 2019,11(8): 1951.
[13] FAXEN-IRVING G, BASUN H, CEDERHOLM T. Nutritional and cognitive relationships and long-term mortality in patients with various dementia disorders[J]. Age Ageing, 2005,34(2): 136-141.
[14] BARDON L A, CORISH C A, LANE M, et al. Ageing rate of older adults affects the factors associated with, and the determinants of malnutrition in the community: a systematic review and narrative synthesis[J]. BMC Geriatr, 2021,21(1):676.
[15] 李玲, 王峥. 阿尔茨海默病患者营养状况及其影响因素分析[J]. 中国医学前沿杂志:电子版, 2019,11(4): 113-116.
[16] ESPINOSA-VAL M C, MARTÍN-MARTÍNEZ A, GRAUPERA M, et al. Prevalence, risk factors, and complications of oropharyngeal dysphagia in older patients with dementia[J]. Nutrients, 2020,12(3): 863.
[17] IMAOKA M, NAKAO H, NAKAMURA M, et al. Effect of multicomponent exercise and nutrition support on the cognitive function of older adults: a randomized controlled trial[J]. Clin Interv Aging, 2019, 14: 2145-2153.
[18] KÜLZOW N, WITTE A V, KERTI L, et al. Impact of Omega-3 fatty acid supplementation on memory functions in healthy older adults[J]. J Alzheimers Dis, 2016,51(3): 713-725.
[19] POWER R, NOLAN J M, PRADO-CABRERO A, et al. Omega-3 fatty acid, carotenoid and vitamin E supplementation improves working memory in older adults: a randomised clinical trial[J]. Clin Nutr, 2022,41(2): 405-414.
[20] MARTÍN M A C, ORTEGA S B, RODRÍGUEZ L D, et al. Presence of malnutrition and risk of malnutrition in institutionalized elderly with dementia according to the type and deterioration stage[J]. Nutr Hosp, 2023,2(27): 434-440.
[21] 刘欣艳, 刘闻莺, 余雪君, 等. 营养状况与阿尔兹海默病的相关性研究[J]. 中国医药导报, 2014,11(18): 62-65.

Study on the correlation of cognitive function with swallowing function and nutritional status in the elderly patients with Alzheimer’s disease

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 3

Metrics

Recommended 10

[1]	MA Shengjun, ZHENG Aibo, SHEN Yibo, GU Li, SUN Kai, HUANG Dan. Effects of personalized nutrition intervention on lung function and immune status in elderly patients with chronic obstructive pulmonary disease [J]. Practical Geriatrics, 2024, 38(7): 683-687.
[2]	LIU Tian, YANG Rongli, HAN Huiping. Value of serum levels of Aβ1-42 and Bcl-2 in predicting the pathogenesis of Alzheimer’s disease in elderly patients with cognitive impairment [J]. Practical Geriatrics, 2024, 38(6): 582-586.
[3]	CHANG Xinxin, PAN Bei, KUANG Wen, DU Wenjin, LIU Wei, LI Yumeng, GUO Xiumin, CHEN Dawei. Reliability and validity of the Chinese version of Assessment of Swallowing Ability for Pneumonia in Chinese elderly patients with central nervous system diseases [J]. Practical Geriatrics, 2024, 38(6): 612-616.