个性化营养干预对老年慢性阻塞性肺疾病病人肺功能及免疫状态的影响

doi:10.3969/j.issn.1003-9198.2024.07.009

Abstract

Abstract: Objective To explore the effects of personalized nutrition intervention on lung function and immune status in the elderly patients with chronic obstructive pulmonary disease (COPD)and malnutrition risk. Methods A total of 128 elderly COPD patients with malnutrition risk screened by Nutrition Risk Screening 2002(NRS 2002) score were divided into the personalized nutrition intervention group and the control group according to random number table method,with 64 cases in each group.The personalized nutrition intervention group was given individualized nutrition treatment,and the control group was given routine nutrition guidance.The indexes of nutritional status, lung function, exercise tolerance and immune status were observed and compared after 3 months of treatment. Results After treatment, the indexes of nutritional status, lung function, exercise tolerance and immune status in the individualized nutrition intervention group were all significantly improved compared with those before treatment(P<0.05), and showed significant difference with those in the control group(P<0.05).The indexes of nutritional status and immune status in the control group were significantly improved after treatment(P<0.05),while there were no significant difference in the lung function and exercise tolerance(P>0.05). Conclusions Individualized nutritional intervention can improve nutritional status, enhance lung function and exercise tolerance, and restore immune status in the elderly COPD patients with the risk of malnutrition.

Key words: personalized nutritional intervention, malnutrition, chronic obstructive pulmonary disease, lung function, immune state

CLC Number:

R 563

MA Shengjun, ZHENG Aibo, SHEN Yibo, GU Li, SUN Kai, HUANG Dan. Effects of personalized nutrition intervention on lung function and immune status in elderly patients with chronic obstructive pulmonary disease[J]. Practical Geriatrics, 2024, 38(7): 683-687.

References

[1] BARNES P J.Cellular and molecular mechanisms of asthma and COPD[J].Clin Sci:Lond,2017,131(13):1541-1558.
[2] CHEN X,GONG D,HUANG H,et al.Expert consensus and operational guidelines on exercise rehabilitation of chronic obstructive pulmonary disease with integrating traditional Chinese medicine and Western medicine[J].J Thorac Dis,2021,13(6):3323-3346.
[3] QUAN Z Y,YAN G H,WANG Z G,et al.Current status and preventive strategies of chronic obstructive pulmonary disease in China: a literature review[J].J Thorac Dis,2021,13(6):3865-3877.
[4] DAVE S,ALVAR A,ANTONIO A,et al.Global strategy for the diagnosis,management,and prevention of chronic obstructive lung disease:the GOLD Science Committee Report 2019[J].Eur Respir,2019,53(5):1900164.
[5] OGAN N,YILDIRIM F,SUZEN B,et al.Does nutritional risk screening 2002 correlate with the dyspnea status of patients with GOLD stage C-D chronic obstructive pulmonary disease[J].Turk Thorac J,2020,21(1):49-53.
[6] MIKI K,MAEKURA R,KITADA S,et al.Pulmonary rehabilitation for COPD improves exercise time rather than exercise tolerance: effects and mechanisms[J].Int J Chron Obstruct Pulmon Dis,2017,12(5):1061-1075.
[7] 中华医学会老年医学分会.老年医学(病)科临床营养管理指导意见[J].中华老年医学杂志,2015,34(12):1388-1395.
[8] BERNABEU M R,MEDINA M F,LlAMAZARES H E,et al.The accuracy with which the 5 times sit-to-stand test,versus gait speed,can identify poor exercise tolerance in patients with COPD:a cross-sectional study[J].Medicine:Baltimore,2016,95(35):e4740.
[9] LAW S,KUMAR P,WOODS S,et al.Malnutrition screening in patients admitted to hospital with an exacerbation of chronic obstructive pulmonary disease and its association with patient outcomes[J].Hosp Pract,2016,44(4):207-212.
[10] SPRIT M A,PITTA F,MCAULEY E,et al. Pulmonary rehabilitation and physical activity in patients with chronic obstructive pulmonary disease[J]. Am J Respir Crit Care Med,2015,192(8):924-933.
[11] LUO Y,ZHOU L,LI Y,et al.Fat-free mass index for evaluating the nutritional status and disease severity in COPD[J].Respir Care,2016,61(5):680-688.
[12] 程燕,王妍,李永乐,等.基于CGA的干预措施在老年COPD稳定期合并营养不良患者中的效果评价][J].华北理工大学学报(医学版),2019,21(4):264-269.
[13] 黄兆晶,刘红,何兴月,等.基于老年综合评估的多学科营养管理模式在老年病房中的应用研究[J].实用老年医学,2023,37(1): 92-95.
[14] DURHEIM M T,CYR D D,LOPES R D,et al. Chronic obstructive pulmonary disease in patients with atrial fibrillation: Insights from the ARISTOTLE trial[J].Int J Cardiol,2016,202(5):589-594.
[15] 王鹏,王双,李伟,等.早期个体化序贯营养支持对老年慢性阻塞性肺疾病急性加重病人预后的影响[J].实用老年医学,2022,36(1):61-64.

Effects of personalized nutrition intervention on lung function and immune status in elderly patients with chronic obstructive pulmonary disease

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