肺力咳合剂联合噻托溴铵粉雾剂在高龄慢性阻塞性肺疾病病人中的效果观察

doi:10.3969/j.issn.1003-9198.2024.10.010

Abstract

Abstract: Objective To observe the effect of Feilike Mixture combined with tiotropium bromide powder aerosol in elderly patients aged≥80 years old with chronic obstructive pulmonary disease (COPD). Methods From May 2016 to January 2021, 86 elderly patients with COPD were selected and divided into the study group (n=43) and the control group (n=43) by random number table method. Both groups received basic treatment, and the control group received tiotropium bromide powder inhalation, and the study group received Feilike mixture treatment on the basis of the control group. Both groups were treated for 2 weeks. Lung function, immune function, cytokine level, clinical efficacy, relevant scale score and adverse reactions were compared between the two groups. Results After treatment, the levels of peak expiratory flow rate (PEF), forced expiratory volume in 1 second (FEV1), FEV1/ forced vital capacity (FVC), CD3⁺ and CD4⁺, helper T cell 17 (Th17)/regulatory T cell (Treg),interleukin-10 (IL-10) and the scores of Health Survey Summary Form (SF-36) were all significantly increased in both groups (P<0.05), especially in the study group (P<0.05). After treatment, the levels of CD8⁺and IL-17,the score of chronic obstructive pulmonary disease assessment test (CAT) were significantly decreased in both groups (P<0.05), especially in the study group (P<0.05). The total effective rate in the study group was significanthy higher than that in the control group (95.35% vs. 79.07%, P<0.05). There was no difference in the total incidence rate of adverse reactions between the two groups (P>0.05). Conclusions Feilike Mixture combined with tiotropium bromide powder aerosol is effective in the treatment of COPD in the elderly patients aged ≥80 years old, which can safely improve the immune function, lung function and quality of life of the patients, and reduce inflammation and regulate Th17/Treg balance.

Key words: Feilike Mixture, tiotropium bromide powder aerosol, aged ≥80 years old, chronic obstructive pulmonary disease, clinical effect, safety

CLC Number:

R 563

ZHOU Yun, ZHANG Yingying, GAO Yanfen. Effect of Feilike Mixture combined with tiotropium bromide powder aerosol in elderly patients aged≥80 years old with chronic obstructive pulmonary disease[J]. Practical Geriatrics, 2024, 38(10): 1011-1015.

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Effect of Feilike Mixture combined with tiotropium bromide powder aerosol in elderly patients aged≥80 years old with chronic obstructive pulmonary disease

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