黄葵胶囊联合司美格鲁肽治疗老年糖尿病肾病的临床疗效分析

doi:10.3969/j.issn.1003-9198.2024.10.009

Abstract

Abstract: Objective To analyze the clinical effects of Huangkui capsule combined with semaglutide in the treatment of diabetic nephropathy in the elderly. Methods A total of 102 elderly patients with diabetic nephropathy treated in Lianyungang First People’s Hospital from June 2021 to August 2023 were selected and divided into control group and study group by random number table method, with 51 cases in each group. The control group was treated with semaglutide, and the study group was treated with Huangkui capsule on the basis of the control group. Both groups were treated for 3 months. The levels of blood glucose and renal function, clinical efficacy, inflammatory reactions and adverse reactions were compared between the two groups. Results After treatment, the levels of glycosylated hemoglobin (HbA1c), 2 h postprandial plasma glucose (2hPPG) and fasting plasma glucose (FPG) in the two groups were significantly decreased (P<0.05), with no significant differences between the two groups (P>0.05). After treatment, the levels of serum creatinine, urinary albumin-to-creatinine ratio (UACR) and 24 h urinary protein quantity (24hUTP) in the two groups were significantly decreased (P<0.05), especially in the study group (P<0.05). The total effective rate in the study group was higher than that in the control group (90.20% vs. 72.55%, P<0.05). After treatment, the levels of serum transforming growth factor β (TGF-β), intercellular cell adhesion molecule-1 (ICAM-1) and high mobility group protein B1 (HMGB1) in the two groups were significantly decreased (P<0.05), especially in the study group (P<0.05). There was no difference in the total incidence rate of adverse reactions between the two groups (P>0.05). Conclusions Semaglutide combined with Huangkui capsule can protect renal function in the elderly patients with diabetic nephropathy, reduce inflammatory response and maintain stable blood glucose, with significant effect and good safety.

Key words: Huangkui capsule, semaglutide, aged, diabetic nephropathy, clinical effect, security

CLC Number:

R 587.2

LI Yuhan, LI Da, WU Hengyu. Efficacy of Huangkui capsule combined with semaglutide in the treatment of diabetic nephropathy in the elderly[J]. Practical Geriatrics, 2024, 38(10): 1007-1010.

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Efficacy of Huangkui capsule combined with semaglutide in the treatment of diabetic nephropathy in the elderly

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