老年COPD急性加重期病人血清IL-33/sST2轴表达及其对预后的预测价值

doi:10.3969/j.issn.1003-9198.2024.10.017

Abstract

Abstract: Objective To investigate the expression of serum interleukin-33 (IL-33)/soluble ST2 (sST2) axis in the elderly patients with acute exacerbation chronic obstructive pulmonary disease (AECOPD) and its prognostic value. Methods A total of 138 elderly patients with AECOPD admitted to Beijing Huairou Hospital from June 2019 to June 2022 were enrolled in the study group, and 138 elderly patients with stable COPD admitted to our hospital during the same period were enrolled in the control group. The serum levels of IL-33, sST2, IL-4 and IL-10 were detected and compared between the two groups, and the patients in the study group were divided into good prognosis group and poor prognosis group. Logistic regression analysis was used to evaluate the risk factors affecting the prognosis of the elderly patients with AECOPD, and receiver operating characteristic (ROC) curve was drawn to analyze the predictive value of serum IL-33, sST2, IL-4 and IL-10 levels for the prognosis of the elderly patients with AECOPD. Results The levels of IL-33 and sST2 in the study group were higher and the levels of IL-4 and IL-10 were lower in the study group than those in the control group (P<0.05). Among the 138 patients in the study group, 9 cases( 6.52%) were lost to follow-up. Among the 129 patients, 30 cases (23.26%) presented with poor prognosis. The levels of serum IL-33 and sST2, course of disease and proportion of complications number ≥2 in the poor prognosis group were higher than those in the good prognosis group (P<0.05), and the levels of IL-4 and IL-10 were lower than those in the good prognosis group (P<0.01). Logistic regression analysis showed that the levels of IL-33 and sST2, course of disease and complications number ≥2 were independent risk factors, and IL-4 and IL-10 were protective factors for poor prognosis in the elderly patients with AECOPD (P<0.05). ROC curve showed that the area under the curve of combined detection of serum IL-33, sST2, IL-4 and IL-10 predicting poor prognosis in the elderly patients with AECOPD was 0.864, which was higher than that of serum IL-33, sST2, IL-4 and IL-10 alone (P<0.05). Conclusions The abnormal expression of serum IL-33, sST2, IL-4 and IL-10 is closely related to the prognosis in the elderly patients with AECOPD, and the combined detection of these indicators has a higher predictive value for the poor prognosis of the elderly patients with AECOPD.

Key words: aged, chronic obstructive pulmonary disease, acute exacerbation stage, interleukin-33, soluble ST2

CLC Number:

R 563.9

LEI Wanfeng, MA Xiuhong. Study on expression of serum IL-33/sST2 axis in elderly patients with acute exacerbation of COPD and its predictive value for prognosis[J]. Practical Geriatrics, 2024, 38(10): 1044-1048.

References

[1] BARTZIOKAS K, PAPAPORFYRIOU A, HILLAS G, et al. Global initiative for chronic obstructive lung disease (GOLD) recommendations: strengths and concerns for future needs[J]. Postgrad Med, 2023, 135(4):327-333.
[2] CHEN J, YIN Y, ZHANG Y, et al. Chronic obstructive pulmonary disease prevalence and associated risk factors in adults aged 40 years and older in southeast china: a cross-sectional study during 2019-2020[J]. Int J Chron Obstruct Pulmon Dis, 2022, 17:2317-2328.
[3] PHILLIPS T M, MOLONEY C, SNEATH E, et al. Associated factors, assessment, management, and outcomes of patients who present to the emergency department for acute exacerbation of chronic obstructive pulmonary disease: a scoping review[J]. Respir Med, 2022, 193:106747.
[4] KAUR D, MEHTA R L, JARRETT H, et al. Phase III, two arm, multi-centre, open label, parallel-group randomised designed clinical investigation of the use of a personalised early warning decision support system to predict and prevent acute exacerbations of chronic obstructive pulmonary disease: ‘Predict & Prevent AECOPD’ - study protocol[J]. BMJ Open, 2023, 13(3):e061050.
[5] RYAN E M, SADIKU P, COELHO P, et al. NRF2 activation reprograms defects in oxidative metabolism to restore macrophage function in chronic obstructive pulmonary disease[J]. Am J Respir Crit Care Med, 2023, 207(8):998-1011.
[6] 李慧娇, 王一萍, 何薇, 等. 慢性阻塞性肺疾病患者血清可溶性基质裂解素2、白细胞介素-33水平及其与疾病严重程度的关系研究[J]. 中国卫生检验杂志, 2021, 31(17):2102-2104, 2108.
[7] 中华医学会, 中华医学会杂志社, 中华医学会全科医学分会, 等. 慢性阻塞性肺疾病基层诊疗指南(2018年)[J]. 中华全科医师杂志, 2018, 17(11):856-870.
[8] WANG Z, LOCANTORE N, HALDAR K, et al. Inflammatory endotype-associated airway microbiome in chronic obstructive pulmonary disease clinical stability and exacerbations: a multicohort longitudinal analysis[J]. Am J Respir Crit Care Med, 2021, 203(12):1488-1502.
[9] 伍桂雄, 董树烽, 农美蓉, 等. 慢性阻塞性肺疾病急性加重期患者血清CCL18、IL-17水平的变化及临床意义[J]. 中国医师杂志, 2021, 23(7):1073-1077.
[10] 严英, 刘博伟, 马春明, 等. 慢性阻塞性肺疾病急性加重期患者死亡风险预测模型构建及效能验证[J]. 山东医药, 2021, 61(3):51-55.
[11] HSIEH M H, CHEN P C, HSU H Y, et al. Surfactant protein D inhibits lipid-laden foamy macrophages and lung inflammation in chronic obstructive pulmonary disease[J]. Cell Mol Immunol, 2023, 20(1):38-50.
[12] YOUSUF A J, MOHAMMED S, CARR L, et al. Astegolimab, an anti-ST2, in chronic obstructive pulmonary disease (COPD-ST2OP): a phase 2a, placebo-controlled trial[J]. Lancet Respir Med, 2022, 10(5):469-477.
[13] 陈志勇, 罗世林, 张健, 等. 慢阻肺患者血清IL-17,IL-27和IL-33水平表达及与不同临床分期FeNO和肺功能的相关性研究[J]. 现代检验医学杂志, 2021, 36(4):152-155, 166.
[14] SINGH H, KHURANA A, KUMAR A, et al. Serum levels of interleukin-33, soluble ST2 and IgE in patients with asthma: a case-control study[J]. J Asthma, 2024, 61(1):48-57.
[15] 张曙晴, 张骆军, 周小林,等. 慢性阻塞性肺疾病患者血清IL-33、sST2、CRP水平与病情严重程度的相关性研究[J]. 中国实验诊断学, 2021, 25(11):1610-1613.
[16] URBAN M H, STOJKOVIC S, DEMYANETS S, et al. Soluble ST2 and all-cause mortality in patients with chronic obstructive pulmonary disease—a 10-year cohort study[J]. J Clin Med, 2021, 11(1):56.
[17] 张绍塘, 陈伦, 叶健. 多索茶碱联合盐酸氨溴索对老年稳定期慢阻肺患者血清IL-33/sST2轴表达的影响[J]. 中国临床药理学杂志, 2022, 38(4):291-295.

Study on expression of serum IL-33/sST2 axis in elderly patients with acute exacerbation of COPD and its predictive value for prognosis

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Metrics

Recommended 10

[1]	LI Jiang, QIU Yan, WANG Ting, WANG Dan, YU Yifan, PU Lingli, BU Ling. Correlation between preoperative SII/ALB and clinicopathologic features in elderly patients with lung adenocarcinoma [J]. Practical Geriatrics, 2024, 38(9): 893-896.
[2]	DAI Jing, CUI Yan. Correlation between glycosylated hemoglobin variability and cognitive dysfunction in elderly patients with type 2 diabetes mellitus [J]. Practical Geriatrics, 2024, 38(9): 931-935.
[3]	ZHENG Hong, QI Zhenbo, XU Peng, XU Jie, YU Xinyu, ZANG Yanan, ZHANG Zhaoyan. Effects of hypnotics on cognition function and daytime sleepiness in the elderly [J]. Practical Geriatrics, 2024, 38(9): 936-939.
[4]	ZHANG Xingxing, ZHANG Haiyang, HE Xiaojing, LU Xiang. Investigation on the relationship between different physical indexes and the risk of diabetes mellitus in the elderly [J]. Practical Geriatrics, 2024, 38(9): 940-943.
[5]	NI Hongyan, CHEN Yun, ZHANG Qibing, MA Yiming, XIE Chenglan. Effects of electroacupuncture on cognitive function and inflammatory factors in elderly patients undergoing lower limb orthopedic surgery during the perioperative period [J]. Practical Geriatrics, 2024, 38(9): 944-947.
[6]	LI Xiaomin, LI Xiaolin, LI Jie, WU Lei, HAO Ranran. Efficiency influencing factors of transanal double-balloon enteroscopy in elderly patients [J]. Practical Geriatrics, 2024, 38(9): 958-961.
[7]	CAI Huicui, CHEN Yan, WANG Yan, YE Jinjun, ZHU Yuying. Effects of diversified health education model with simple respiratory function exercise on cancer-related fatigue and compliance behavior in elderly patients with lung cancer receiving radiotherapy [J]. Practical Geriatrics, 2024, 38(9): 968-972.
[8]	WANG Xiaojiao, WANG Ning, CUI Hong, YE Tong, WANG Xiaoming. Influence of exercise rehabilitation in elderly patients with mild to moderate chronic heart failure [J]. Practical Geriatrics, 2024, 38(8): 775-778.
[9]	SHEN Chenjun, WANG Xiaoqing, TANG Degang, NING Ping. Correlation between standardized uric acid and renal function in elderly patients with chronic kidney disease aged 90 and over [J]. Practical Geriatrics, 2024, 38(8): 779-782.
[10]	HAO Shijie, ZOU Jianpeng, WEI Chen, LIU Qingjiang. Effect of comprehensive respiratory training on hypokinetic dysarthria in elderly patients with Parkinson’s disease [J]. Practical Geriatrics, 2024, 38(8): 783-787.
[11]	XIANG Chao, LUO Caidong. Analysis of the diagnostic value of T wave change of avL lead for the degree of coronary artery stenosis in elderly patients with coronary heart disease [J]. Practical Geriatrics, 2024, 38(8): 788-791.
[12]	LI Huiying, CAI Lili, ZHU Qiwei. Predictive value of plasma N-terminal pro-brain natriuretic peptide for prognosis in patients aged ≥80 years old with left ventricular hypertrophy [J]. Practical Geriatrics, 2024, 38(8): 797-801.
[13]	WANG Xinping, XIE Baimei, WEI Guo, YE Xiaoli, ZHAO Yayun, TAN Xiaotian. Expression levels and clinical significance of serum S100A9 and sCD163 in elderly patients with idiopathic interstitial pneumonia [J]. Practical Geriatrics, 2024, 38(8): 802-807.
[14]	LIU Meijuan, WANG Ning, WANG Dong, LU Fangzhou, LIU Juan. Effect of low-dose lidocaine combined with propofol on motor evoked potential in elderly patients undergoing intracranial tumor resection [J]. Practical Geriatrics, 2024, 38(8): 808-811.
[15]	LI Jingbing, WANG Huijun, WANG Shaoying, ZHAO Can, WANG Lidi, CAO Yujiao. Impacts of pentoxifylline combined with lipoic acid intervention on physical function and quality of life in elderly patients with frailty syndrome [J]. Practical Geriatrics, 2024, 38(8): 812-815.