抗阻运动对老年人炎症水平影响的Meta分析

doi:10.3969/j.issn.1003-9198.2022.11.007

Abstract

Abstract: Objective To investigate the effect of resistance training on inflammation in the elderly and to provide some basis for the formulation of exercise prescription. Methods Randomized controlled trials on the effects of resistance training on inflammation factors in the elderly people were retrieved from the databases.The retrieved literatures were screened and the data were extracted, and Meta-analysis was performed using RevMan 5.3 software. Results A total of 11 literatures were enrolled, including 404 subjects.The results showed that resistance training reduced the levels of inflammation factors in the elderly people, including C-reactive protein (CRP), tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6). Subgroup analysis showed that the level of CRP was decreased more significantly when the number of exercise was over 8. The effect of high intensity resistance training on TNF-α was better in elderly people. Resistance training was more effective in reducing IL-6 when the duration was less than 12 weeks, the number of exercise was over 8, and the frequency was more than 2 times per week. Conclusions Resistance training has a good effect on alleviating chronic inflammation in the elderly.

Key words: resistance training, aged, inflammation, C-reactive protein, tumor necrosis factor, interleukin-6, Meta-analysis

CLC Number:

R493

YU Ya-lin, GUO Rui-ying, ZHANG Xue-yan, DONG Bo. Meta-analysis of the effect of resistance training on inflammation in elderly people[J]. Practical Geriatrics, 2022, 36(11): 1106-1111.

References

[1] SOYSAL P, STUBBS B, LUCATO P, et al. Inflammation and frailty in the elderly:a systematic review and meta-analysis[J]. Ageing Res Rev, 2016, 31:1-8.
[2] LAVIN K M, PERKINS R K, JEMIOLO B, et al. Effects of aging and lifelong aerobic exercise on basal and exercise-induced inflammation[J]. J Appl Physiol, 2020, 128(1):87-99.
[3] DE SOUZA TEIXEIRA A A, LIRA F S, ROSA-NETO J C. Aging with rhythmicity. Is it possible? Physical exercise as a pacemaker[J]. Life Sci, 2020, 261:118453.
[4] FABBRI E, AN Y, ZOLI M, et al. Aging and the burden of multimorbidity: associations with inflammatory and anabolic hormonal biomarkers[J]. J Gerontol A Biol Sci Med Sci, 2015, 70(1):63-70.
[5] BEAVERS K M, BRINKLEY T E, NICKLAS B J. Effect of exercise training on chronic inflammation[J]. Clin Chim Acta, 2010, 411(11/12):785-793.
[6] LOPEZ P, PINTO R S, RADAELLI R, et al. Benefits of resistance training in physically frail elderly: a systematic review[J]. Aging Clin Exp Res, 2018, 30(8):889-899.
[7] TOMELERI C M, RIBEIRO A S, SOUZA M F, et al. Resistance training improves inflammatory level, lipid and glycemic profiles in obese older women: a randomized controlled trial[J]. Exp Gerontol, 2016, 84:80-87.
[8] TOMELERI C M, RIBEIRO A S, CAVAGLIERI C R, et al. Correlations between resistance training-induced changes on phase angle and biochemical markers in older women[J]. Scand J Med Sci Sports, 2018, 28(10):2173-2182.
[9] WANDERLEY F A, MOREIRA A, SOKHATSKA O, et al. Differential responses of adiposity, inflammation and autonomic function to aerobic versus resistance training in older adults[J]. Exp Gerontol, 2013, 48(3):326-333.
[10] IHALAINEN J K, INGLIS A, MÄKINEN T, et al. Strength training improves metabolic health markers in older individual regardless of training frequency[J]. Front Physiol, 2019, 10:32.
[11] MONTEIRO-JUNIOR R S, MACIEL-PINHEIRO P T, PORTUGAL E D M, et al. Effect of exercise on inflammatory profile of older persons: systematic review and Meta-analyses[J]. J Phys Act Health, 2018, 15(1):64-71.
[12] 刘伊依, 邱俊强, 衣龙燕, 等. 接受抗阻训练中老年人白细胞介素6与C-反应蛋白变化的Meta分析[J]. 中国组织工程研究, 2022, 26(5):843-851.
[13] CHUPEL M U, DIREITO F, FURTADO G E, et al. Strength training decreases inflammation and increases cognition and physical fitness in older women with cognitive impairment[J]. Front Physiol, 2017, 8:377.
[14] CUNHA P M, RIBEIRO A S, NUNES J P, et al. Resistance training performed with single-set is sufficient to reduce cardiovascular risk factors in untrained older women: the randomized clinical trial. Active Aging Longitudinal Study[J]. Arch Gerontol Geriatr, 2019, 81:171-175.
[15] HSIEH P L, TSENG C H, JANE TSENG Y F, et al. Resistance training improves muscle function and cardiometabolic risks but not quality of life in older people with type 2 diabetes mellitus: a randomized controlled trial[J]. J Geriatr Phys Ther, 2018, 41(2):65-76.
[16] MARTINS R A, NEVES A P, COELHO-SILVA M J, et al. The effect of aerobic versus strength-based training on high-sensitivity C-reactive protein in older adults[J]. Eur J Appl Physiol, 2010, 110(1):161-169.
[17] RODRIGUEZ-MIGUELEZ P, FERNANDEZ-GONZALO R, ALMAR M, et al. Role of toll-like receptor 2 and 4 signaling pathways on the inflammatory response to resistance training in elderly subjects[J]. Age: Dordr, 2014, 36(6):9734.
[18] RODRIGUEZ-MIGUELEZ P, FERNANDEZ-GONZALO R, COLLADO P S, et al. Whole-body vibration improves the anti-inflammatory status in elderly subjects through toll-like receptor 2 and 4 signaling pathways[J]. Mech Ageing Dev, 2015, 150:12-19.
[19] STRANDBERG E, EDHOLM P, PONSOT E, et al. Influence of combined resistance training and healthy diet on muscle mass in healthy elderly women:a randomized controlled trial[J]. J Appl Physiol, 2015, 119(8):918-925.
[20] TOMELERI C M, SOUZA M F, BURINI R C, et al. Resistance training reduces metabolic syndrome and inflammatory markers in older women: a randomized controlled trial[J]. J Diabetes, 2018, 10(4):328-337.
[21] GARBER C E, BLISSMER B, DESCHENES M R, et al. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise[J]. Med Sci Sports Exerc, 2011, 43(7):1334-1359.
[22] CHEN W K, TSAI Y L, SHIBU M A, et al. Exercise training augments Sirt1-signaling and attenuates cardiac inflammation in D-galactose induced-aging rats[J]. Aging (Albany NY), 2018, 10(12):4166-4174.
[23] HÄKKINEN K, PAKARINEN A. Serum hormones and strength development during strength training in middle-aged and elderly males and females[J]. Acta Physiol Scand, 1994, 150(2):211-219.

Meta-analysis of the effect of resistance training on inflammation in elderly people

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