Abstract: Objective To investigate the correlation of 25 hydroxyvitamin D [25(OH)D] and homocysteine (Hcy) with frailty in the elderly hospitalized patients. Methods A total of 130 hospitalized elderly patients in Department of Geriatric Center of Xinjiang Uygur Autonomous Region People's Hospital from January to June 2022 were enrolled in this study. According to the score of Fried Scale, all patients were divided into non-frailty group, pre-frailty group and frailty group. The clinical data were collected and compared among the three groups. Spearman rank correlation analysis was used to evaluate the correlation between each index and frailty degree. And binary Logistic regression was used to analyze the risk factors of frailty in the elderly hospitalized patients. Results There were significant differences in age, the levels of hemoglobin, Hcy, 25(OH)D, and the rate of comorbidities among the three groups (P<0.05). Frailty score was positively correlated with age, the number of combined drugs, the type of comorbidity and the level of Hcy (P<0.05), and negatively correlated with the level of 25(OH)D (P<0.05). Binary Logistic regression analysis showed that 25(OH)D (OR=0.541; 95%CI: 0.373-0.786) and Hcy (OR=1.694; 95% CI: 1.155-2.485) were independently correlated with frailty. Conclusions 25(OH)D and Hcy are independently correlated with frailty, and 25(OH)D is a protective factor of frailty, and Hcy is a risk factor of frailty.

Key words: aged, frailty, 25-hydroxyvitamin D, homocysteine