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20 July 2023, Volume 37 Issue 7 Previous Issue    Next Issue

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Effect of glycopyrrolate on pulmonary function and pulmonary shunt in elderly patients with lung cancer undergoing radical resection YUAN Yi-dan, LIU Zeng, LU Xi-hua 2023, 37 (7):  662-666.  doi: 10.3969/j.issn.1003-9198.2023.07.005 Abstract ( 125 )   PDF (1074KB) ( 835 )   Save Objective To observe the effect of glycopyrrolate on pulmonary function and pulmonary shunt in the elderly patients undergoing radical resection of lung cancer. Methods Ninety elderly patients undergoing radical resection of lung cancer were randomly divided into glycopyrrolate group (group G) and control group (group N), with 45 patients in each group. The patients in group G were intravenously injected with glycopyrrolate (5 μg/kg), while the patients in group N were intravenously injected with 0.9% sodium chloride 10 min before anesthesia induction. The hemodynamics of the patients were observed continuously at 6 time points, before anesthesia induction (T0), two lung ventilation for 15 min after endotracheal intubation (T1) and 15 min (T2), 30 min (T3), 40 min (T4), 50 min (T5) after one-lung ventilation. Airway resistance (Raw), pulmonary compliance (Comp) and peak airway pressure (Ppeak) were recorded at T1, T2, T3, T4 and T5. Arterial blood and internal carotid venous blood were collected at T1, T2, and T3 for blood gas analysis. PaO2 and PaCO2 were recorded, and the intrapulmonary shunt rate (Qs/Qt) was calculated. Results After one-lung ventilation, the level of PaO2 decreased, and the levels of Qs/Qt, PaCO2 increased at T2 and T3 (P＜0.05); The levels of Raw and Ppeak increased at T2-T5 (P＜0.05). Compared with group N, the level of Comp of group G was higher, and the level of Ppeak was lower at T3-T5, and the level of Qs/Qt was lower at T2 and T3 (P＜0.05). Conclusions Intravenous injection of glycopyrrolate can dilate bronchus, reduce intrapulmonary shunt, improve lung compliance, protect lung function without influencing the hemodynamics in the elderly patients undergoing radical resection of lung cancer. References | Related Articles | Metrics

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Correlation of 25-hydroxyvitamin D and homocysteine with frailty in elderly hospitalized patients in Xinjiang YU Zhi-chao, CHEN Nan, XU Hong 2023, 37 (7):  667-670.  doi: 10.3969/j.issn.1003-9198.2023.07.006 Abstract ( 126 )   PDF (1056KB) ( 865 )   Save Objective To investigate the correlation of 25 hydroxyvitamin D [25(OH)D] and homocysteine (Hcy) with frailty in the elderly hospitalized patients. Methods A total of 130 hospitalized elderly patients in Department of Geriatric Center of Xinjiang Uygur Autonomous Region People's Hospital from January to June 2022 were enrolled in this study. According to the score of Fried Scale, all patients were divided into non-frailty group, pre-frailty group and frailty group. The clinical data were collected and compared among the three groups. Spearman rank correlation analysis was used to evaluate the correlation between each index and frailty degree. And binary Logistic regression was used to analyze the risk factors of frailty in the elderly hospitalized patients. Results There were significant differences in age, the levels of hemoglobin, Hcy, 25(OH)D, and the rate of comorbidities among the three groups (P<0.05). Frailty score was positively correlated with age, the number of combined drugs, the type of comorbidity and the level of Hcy (P<0.05), and negatively correlated with the level of 25(OH)D (P<0.05). Binary Logistic regression analysis showed that 25(OH)D (OR=0.541; 95%CI: 0.373-0.786) and Hcy (OR=1.694; 95% CI: 1.155-2.485) were independently correlated with frailty. Conclusions 25(OH)D and Hcy are independently correlated with frailty, and 25(OH)D is a protective factor of frailty, and Hcy is a risk factor of frailty. References | Related Articles | Metrics

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Effect of drinking carbohydrate beverage before anesthesia on gastric volume and perioperative hypotension in elderly patients undergoing thoracic surgery ZHOU Li, QI Xiao-xuan, HAN Yan-fang, WANG Wei-yang, LIU Zai-ying, WANG Kun 2023, 37 (7):  671-675.  doi: 10.3969/j.issn.1003-9198.2023.07.007 Abstract ( 97 )   PDF (1227KB) ( 739 )   Save Objective To investigate the effects of drinking carbohydrate beverage 2 hours before surgery on gastric volume before anesthesia induction and perioperative hypotension in the elderly patients undergoing thoracic surgery. Methods Sixty elderly patients undergoing thoracoscopic lobectomy were randomly divided into two groups, with 30 patients in each group. Control group kept routine fasting before surgery, and experimental group received 5% glucose water 4 mL/kg 2 hours before anesthesia induction. Ultrasonography was performed in both groups after sectional examination, and cross-sectional area (CSA) under semi-recessed position was measured. Gastric volume (GV) and the ratio of gastric volume to body weight (GV/W) were calculated to evaluate the risk of reflux aspiration in the two groups. The systolic blood pressure (SBP), mean arterial pressure (MAP) and heart rate (HR) at T1(5 min after entry), T2(3 min after induction of anesthesia), T3(at the beginning of operation), T4(1 h after operation), T5 (at the end of operation), T6(2 h after operation) and T7 (6 h after operation) were detected by radial invasive arterial BP monitoring. The incidence rate of a perioperative SBP reduction > 20% for over 30 s, the dosage and the usage rate of ephedrine and norepinephrine in the perioperative period and the postoperative conditions of the patients were recorded and compared between the two groups. Results There were no significant differences in the risk of reflux aspiration, CSA and GV between the two groups (P>0.05). The levels of MAP at T2 and T5 were higher in experimental group than those in control group (P<0.05). The incidence rate of perioperative SBP reduction in control group was 75.86%, compared with 44.83% in experimental group ( P<0.05). The utilization rate and dosage of ephedrine and norepinephrine in experimental group were significantly lower than those in control group (P<0.05); Compared with control group, the first postoperative exhaust time was significantly shorter and the incidence rate of nausea and vomiting within 24 hours after surgery was significantly lower in experimental group (P<0.05). Conclusions Drinking 4 mL/kg carbohydrate beverage 2 hours before surgery will not increase the risk of reflux aspiration, but can better maintain the stability of perioperative blood pressure in the elderly patients undergoing thoracic surgery, and promote the recovery of the patients after surgery. References | Related Articles | Metrics

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Effect of BMI on the individualized analgesic effect of sufentanil in elderly patients undergoing thoracoscopic radical resection of lung cancer YAN Zhi-yong, WANG Tao, WU Hao, XU Xu, FAN Qian-nan 2023, 37 (7):  676-679.  doi: 10.3969/j.issn.1003-9198.2023.07.008 Abstract ( 100 )   PDF (1100KB) ( 546 )   Save Objective To investigate the analgesic effect and safety of patient-controlled intravenous analgesia (PCIA) of 2 μg/kg sufentanil in the patients with different body mass index (BMI) undergoing thoracoscopic radical resection of lung cancer during the perioperative period. Methods A total of 168 patients who underwent thoracoscopic radical resection of lung cancer were enrolled in this study. The patients with BMI<18.5 were divided into group A (n=45), the patients with BMI of 18.5～<24.0 divided into group B (n=71), and those with BMI>24.0 divided into group C (n=52). The analgesic effect, number of analgesic pump compressions and adverse analgesic reactions in the three groups were recorded and compared. Results At the time of 24 and 48 hours after surgery, the score of resting pain in group A was significantly higher than that during postoperative wakefulness, and significantly higher than that in group B and group C at the same time point (P<0.05). Forty-eight hours after surgery, the cough pain score in group A was higher than that in group B and group C (P<0.05). There were statistically significant differences in the number of analgesic pump compressions among the three groups 24 and 48 hours after surgery (P<0.05). There were no statistically significant differences in the incidence rate of adverse reactions such as nausea, vomiting, skin itching, and excessive sedation among the three groups (P>0.05). Conclusions BMI may affect the individualized analgesic effect of sufentanil in the elderly patients undergoing thoracoscopic radical resection of lung cancer. For the elderly patients with BMI<18.5, the dosage of sufentanil by PCIA calculated according to body mass can be appropriately increased. References | Related Articles | Metrics

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Relationship between IL-18, PRL-3 and PI3K/AKT signaling pathways in elderly patients with colorectal cancer complicated with liver metastases WANG Xue, QIU Ting, LYU Yi-fei, GAO Shu-juan, GUO Xue-yan 2023, 37 (7):  680-684.  doi: 10.3969/j.issn.1003-9198.2023.07.009 Abstract ( 109 )   PDF (1078KB) ( 726 )   Save Objective To explore the relationship of interleukin-18 (IL-18) and phosphatase of regenerating liver-3 (PRL-3) with phosphatidylinositol-3-kinase (PI3K)/protein kinase B (AKT) signaling pathways in the elderly patients with colorectal cancer (CRC) complicated with liver metastases. Methods A total of 100 elderly patients with CRC in our hospital were enrolled from June 2019 to June 2021. The expressions of IL-18, PRL-3, PI3K and AKT proteins in cancer tissues and para-carcinoma tissues were detected by Western Blot and compared. According to presence or absence of liver metastases, all patients were divided into metastases group (n=34) and non-metastases group (n=66). The risk factors of liver metastases were analyzed by Logistic regression analysis. The relationship between IL-18, PRL-3 and PI3K/AKT signaling pathways in liver metastases patients was analyzed by Pearson correlation. Results The expression levels of IL-18, PRL-3, PI3K and AKT proteins in cancer tissues were higher than those in para-carcinoma tissues (P<0.05), which were also higher in metastases group than those in non-metastases group (P<0.05). The proportions of cases with tumor invasion depth of T3-T4, low and moderate differentiation and lymph node metastasis in metastases group were higher than those in non-metastases group (P<0.05). Logistic regression analysis showed that the positive expressions of IL-18, PRL-3, PI3K and AKT proteins, tumor invasion depth of T3-T4, low and moderate differentiation, and lymph node metastasis were all independent risk factors of liver metastases in the elderly patients with CRC (P<0.05). Pearson correlation analysis showed that the expressions of IL-18 and PRL-3 proteins were positively correlated with the expressions of PI3K and AKT proteins in liver metastases patients (P<0.05). Conclusions The expressions of IL-18 and PRL-3 are up-regulated in the elderly patients with CRC and liver metastases, which are positively correlated with PI3K and AKT proteins. IL-18 and PRL-3 are independent risk factors of liver metastases in the elderly patients with CRC. References | Related Articles | Metrics

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A comparative study of skeletal muscle mass detected by DXA and chest CT in subjects undergoing physical examination LIAO Chen-fang, XU Zong-zheng, QI Hui-juan, LI Qing-zhu, WANG De-guo 2023, 37 (7):  685-689.  doi: 10.3969/j.issn.1003-9198.2023.07.010 Abstract ( 116 )   PDF (1068KB) ( 970 )   Save Objective To analyze the correlation between muscle mass lost detected by dual-energy X-ray absorptiometry(DXA) and chest computed tomography(CT), and to explore the potential value of chest CT in the diagnosis of sarcopenia. Methods A retrospective analysis was performed in 80 elderly receiving physical examination who underwent both chest CT examination and DXA body composition analysis. According to the definition of Asian Working Group for sarcopenia(AWGS), all subjects were divided into muscle mass loss group and normal group based on appendicular skeletal mass index(ASMI). The clinical data, muscle radiodensity and skeletal muscle area detected by chest CT were compared between the two groups. According to CT muscle radiodensity of T12, muscle mass loss was defined(male with CT value <37.5 Hu; female with CT value <31.5 Hu). The consistency of the two methods in diagnosing muscle mass loss was analyzed, and the related factors of muscle mass loss detected by the two methods were analyzed respectively. Results There were 19 cases(23.75%) of people with muscle mass loss judged by DXA. The CT skeletal muscle radiodensity of T12 in the muscle mass loss group was significantly lower than that in the normal group(P<0.05).There were no significant differences in the muscle area and muscle index of T12, L1 and aortic arch cross-sections between the two groups(P>0.05). There were 30 cases(37.5%) with muscle mass loss according to CT muscle radiodensity. The consistency of the two methods was statistically significant but with low efficiency(Kappa=0.281, P=0.008). Correlation analysis showed that ASMI was positively correlated with body mass, BMI, total muscle mass and limb muscle mass detected by DXA(P<0.001), negatively correlated with height(P<0.001). In addition, ASMI was positively correlated with CT muscle radiodensity at T12 and L1 levels(P<0.05). CT muscle radiodensity of T12 were significantly negatively correlated with age and gender(P<0.05), positively correlated with muscle area, area index and CT muscle radiodensity at L1 and aortic arch cross-sections(P<0.05 or P<0.01). Conclusions The diagnostic consistency of muscle mass loss based on CT and DXA is low, which may be due to different relevant factors of CT muscle radiodensity and ASMI. CT muscle radiodensity has comparable consistency at different level of chest muscle with aging effect. Therefore, chest CT scan can be used to evaluate the risk of sarcopenia. References | Related Articles | Metrics

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Injection of platelet-rich plasma under the guidance of ultrasound combined with extracorporeal shock wave treatment for rotator cuff injury WANG Ji-bing, YIN Zheng-lu, MENG Zhao-xiang, WANG Zhan-ye, HUANG Ji-jun, CHEN Bo 2023, 37 (7):  690-694.  doi: 10.3969/j.issn.1003-9198.2023.07.011 Abstract ( 117 )   PDF (1065KB) ( 944 )   Save Objective To observe the efficacy of ultrasound-guided autologous platelet-rich plasma(PRP) injection combined with extracorporeal shock wave(ESW) in the treatment of partial and full-thickness small tear rotator cuff injury. Methods Seventy-five patients with rotator cuff injury were randomly divided into PRP group, ESW group and combined group(PRP+ESW), with 25 patients in each group. In PRP group, autologous PRP treatment was performed under ultrasound guidance for two times; ESW group received ESW treatment for 4 times; Combined group received injection of autologous PRP for 2 times and ESW treatment for 4 times. Before the treatment, at the end of treatment,as well as 4,12 and 24 weeks after treatment, the patients of the three groups were evaluated using Visual Analog Scale(VAS) and Constant-Murley Shoulder Function Score(CMS). Results Compared with that before treatment, the VAS score was decreased at a time-dependent manner after treatment in the three groups(P<0.05); Compared with PRP group, the VAS score in ESW group was lower at the end of treatment and 4 weeks after treatment, and was higher 12 and 24 weeks after treatment(P<0.05). Compared with PRP group and ESW group, the VAS score of the combined group was significantly lower at the end of treatment and 4, 12 and 24 weeks after treatment(P<0.05). Compared with that before treatment, the CMS scores after treatment were significantly higher in the three groups(P<0.05). Compared with PRP group, the CMS score of ESW group was higher at the end of treatment and 4 weeks after treatment, and was lower 12 and 24 weeks after treatment(P<0.05). Compared with PRP group and ESW group, the CMS score of the combined group at the end of treatment and 4, 12 and 24 weeks after treatment were significantly higher than those of the other two groups(P<0.05). Conclusions Injection of PRP under the guidance of ultrasound combined with ESW treatment can significantly relieve the shoulder pain and improve the function of the shoulder joint in the patients with rotator cuff injury. References | Related Articles | Metrics

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Predictive value of systemic immune-inflammatory index for lower extremity deep venous thrombosis in elderly patients with heart failure with reduced ejection fraction YANG Shao-qi, YANG Yang, DENG Li-na, ZHAI Zhi-xin 2023, 37 (7):  695-699.  doi: 10.3969/j.issn.1003-9198.2023.07.012 Abstract ( 113 )   PDF (1116KB) ( 1139 )   Save Objective To evaluate the predictive value of systemic immune-inflammation index (SII) for lower extremity deep venous thrombosis (LEDVT) in the elderly patients with heart failure with reduced ejection fraction (HFrEF). Methods A retrospective study was performed, and a total of 163 elderly HFrEF patients in our hospital from August 2020 to May 2022 were enrolled in this study. The independent risk factors of LEDVT were screened by univariate and multivariate Logistic regression analysis, and the predictive value of the variants for the incidence of LEDVT was evaluated by receiver operating characteristic (ROC) curve. Results Thirty-two cases (19.6%) presented with LEDVT. Compared to the non-LEDVT group, the age, the levels of Autar score, SII and plasma D-dimer at admission were significantly higher in the LEDVT group (P<0.05). Multivariate Logistic regression showed that the level of SII, plasma D-dimer were independent influencing factors of LEDVT. ROC curve showed that SII had significant predictive value for LEDVT with an AUC of 0.782, and the cutoff value of SII was 629×109/L. Kaplan-Meier survival curve analysis showed that the incidence rate of LEDVT in high SII group (>629×109/L) was significantly higher than that in low SII group (χ2=9.133, P=0.003). Conclusions SII level at admission can be used as an independent risk predictor of LEDVT in the elderly patients with HFrEF. References | Related Articles | Metrics

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Effects of cannulated screw combined with three-dimensional honeycomb guide in the treatment of elderly patients with femoral neck fractures SHEN Lin-hua, CAI Cheng-ming, WEI Chen, SHI Ben-hai, DONG Yu-qing 2023, 37 (7):  700-704.  doi: 10.3969/j.issn.1003-9198.2023.07.013 Abstract ( 104 )   PDF (1939KB) ( 764 )   Save Objective To investigate the effect of cannulated screw combined with different positioning screw implantation strategies on the accuracy of screw implantation, hip function score (Harris) and the complications in the treatment of femoral neck fractures in the elderly. Methods A total of 104 elderly patients with femoral neck fractures admitted to our hospital from April 2017 to April 2021 were enrolled and divided into two groups by random number table method, with 52 patients in each group. All patients underwent percutaneous hollow screw internal fixation, and the patients receiving freehand positioning of the nail implant were divided into group B and those receiving new 3D foveal guide assisted positioning of the nail implant were divided into group A. The data of perioperative indexes, imaging indexes, stress hormones, Harris score, visual analogue scale (VAS) score and the complications were collected and compared between the two groups. Results The accuracy rate of screw implantation was significantly higher and the number of guiding needle punctures was significantly lower in group A than those in group B (P＜0.05). Immediately after operation, the parallelism between screws, the axial deviation between screws and neck and the screw coverage area in group A were lower than those in group B, and the distance between screws was greater than that in group B (P＜0.01). The serum levels of cortisol and norepinephrine in group A were lower than those in group B 1 d after operation (P＜0.05). There was no significant difference in Harris and VAS scores between the two groups before operation, 6 months and 12 months after operation (P>0.05). There was no significant difference in the incidence of complications between the two groups (P>0.05). Conclusions The new three-dimensional honeycomb guide-assisted positioning of the screw and the free-hand screw implantation show similar effects in the treatment of femoral neck fractures in the elderly patients. The former helps to improve the accuracy of screw implantation and imaging indicators, with less stress response. References | Related Articles | Metrics

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Analysis of risk factors for delirium in elderly patients with sepsis in intensive care unit ZHAO Yan, XIE Zhi-juan, HONG Sha, LI Qin-fan 2023, 37 (7):  705-708.  doi: 10.3969/j.issn.1003-9198.2023.07.014 Abstract ( 124 )   PDF (1109KB) ( 643 )   Save Objective To investigate the risk factors of sepsis-associated delirium(SAD) in intensive care unit(ICU) in the elderly with sepsis, and to provide reference for clinical diagnosis, treatment and prevention of SAD. Methods A total of 352 elderly patients with sepsis admitted to our hospital from February 2017 to February 2022 were retrospectively enrolled and divided into the SAD group(158 cases) and the non-SAD group(194 cases) according to the confusion-assessment method -ICU-7(CAM-ICU-7) score. The clinical data and laboratory data were collected, and multiple Logistic regression was used to analyze the influencing factors of SAD. Results The age of the SAD group was higher than that of the non-SAD group(P<0.05). The scores of Sequential Organ Failure Assessment (SOFA) and Acute Physiological and Chronic Health Evaluation Ⅱ(APACHE Ⅱ), the proportion of septic shock, mechanical ventilation, sedative use, hyperglycemia, hypercapnia, and the serum levels of interleukin(IL-6), tumor necrosis factor-α(TNF-α), C-reactive protein(CRP) and S-100β protein in the SAD group were higher than those in the non-SAD group(P<0.05). Multivariate Logistic regression analysis showed that age, hyperglycemia, hypercapnia, use of sedative, IL-6, S-100β, SOFA score and APACHE Ⅱ score were risk factors for SAD(P<0.05). Conclusions The incidence of SAD in the elderly patients in ICU is influenced by lots of factors. Positively assessing the parameters is helpful to monitor the incidence of SAD. References | Related Articles | Metrics

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Predictive value of systemic immune-inflammation index and controlled nutritional status score in elderly patients with early distal gastric cancer undergoing total laparoscopic surgery ZHU Bin, XIE Hai-wei, DONG Jian-ning 2023, 37 (7):  709-713.  doi: 10.3969/j.issn.1003-9198.2023.07.015 Abstract ( 106 )   PDF (1072KB) ( 1130 )   Save Objective To explore the predictive efficacy of systemic immune-inflammation index(SII) and controlling nutritional status(CONUT) scores for the prognosis in the elderly patients with early distal gastric cancer undergoing total laparoscopic surgery. Methods From January 2019 to January 2022, a total of 126 elderly patients with early distal gastric cancer who underwent total laparoscopic gastrectomy in our hospital were enrolled. The peripheral blood platelet, lymphocyte count, neutrophil, serum albumin and total cholesterol levels were measured 3 days before the operation, and SII and CONUT score were calculated. According to the 6-month follow-up results, the subjects were divided into the good prognosis group and the poor prognosis group. Multivariate Logistic regression was used to analyze the relevant factors affecting the prognosis. The area under the receiver operating characteristic(ROC) curve(AUC) was used to evaluate the predictive value of SII and CONUT score for prognosis. Results Among 126 elderly patients with early distal gastric cancer, 24 presented with poor prognosis(18.75%). Multivariate Logistic regression analysis showed that older age, higher SII, higher CONUT score and M3 infiltrating muscularis mucosa were the risk factors for poor prognosis in the elderly patients with early distal gastric cancer. The results of ROC curve analysis showed that the AUC of SII and CONUT score alone and combination in predicting the prognosis was 0.706(95%CI: 0.610-0.852), 0.701(95%CI: 0.594-0.826) and 0.809(95%CI: 0.759-0.941) respectively, and the predicting efficiency of the two indexes was lower than that of the combination(P<0.05). Conclusions SII and CONUT score can be used to evaluate the prognosis of elderly patients with early distal gastric cancer. References | Related Articles | Metrics

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Analysis of the frailty status and influencing factors in elderly inpatients with bullous pemphigoid GOU Hui, XIANG Hong-mei, ZOU Qin, CHEN Ji-hui 2023, 37 (7):  714-718.  doi: 10.3969/j.issn.1003-9198.2023.07.016 Abstract ( 107 )   PDF (1073KB) ( 775 )   Save Objective To investigate the frailty status and influencing factors in the elderly inpatients with bullous pemphigoid(BP). Methods A total of 104 elderly inpatients with BP in Department of Dermatology and Venereology, West China Hospital of Sichuan University from August 2020 to February 2022 were selected by convenience sampling method. FRAIL Scale, Barthel Index, Nutrition Risk Screening 2002(NRS2002), and Pittsburgh Sleep Quality Index Scale(PSQI) were applied to evaluate the frailty condition, activities of daily living(ADL), nutritional risks and sleep quality of the elderly hospitalized patients with BP, and the general data, disease-related data and laboratory examination results were collected. Logistic regression was used to analyze the influencing factors of frailty. Results Among the elderly hospitalized patients with BP, 64 cases(61.5%) presented with frailty. Univariate analysis showed that the differences in age, body mass indes(BMI), comorbidities, bed rest, stroke history, coronary heart disease, chronic lung disease, lower limb venous thrombosis, hormonal therapy, the levels of anti-BP-180 antibody, ADL, NRS2002, hemoglobin, serum albumin, C-reactive protein(CRP),brain natriuretic peptide(BNP),glycosylated hemoglobin(HbA1c), total cholesterol and calcium ion between non-frailty/pre-frailty group and frailty group were statistically significant(P<0.05 or P<0.01). Logistic regression analysis showed that age(OR=1.248,95%CI:1.073-1.450)), ADL(OR=0.966,95%CI:0.939-0.993), anti-BP-180 antibody(OR=1.035,95%CI:1.018-1.052), CRP (OR=1.027,95%CI:1.005-1.048), BNP(OR=1.004,95%CI:1.001-1.007)were the influencing factors of frailty in the elderly patients with BP. Conclusions The incidence rate of frailty in the elderly hospitalized patients with BP is high. The elderly hospitalized patients with BP who are older, have decreased self-care ability, elevated anti-BP-180 antibody, elevated CRP and elevated BNP are more prone to presenting with frailty. References | Related Articles | Metrics

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Effect of high flux hemodialysis and hemodiafiltration on the quality of life in elderly patients receiving maintenance hemodialysis XIE Qing-lei, ZHANG Liu-ping, WANG Yue 2023, 37 (7):  719-722.  doi: 10.3969/j.issn.1003-9198.2023.07.017 Abstract ( 79 )   PDF (1048KB) ( 1211 )   Save Objective To investigate the effects of hemodiafiltration (HDF) and high flux hemodialysis ( HFHD) on the quality of life(QOL) in the elderly patients receiving maintenance hemodialysis(MHD). Methods A cross-sectional study was conducted in Blood Purification Center, Zhongda Hospital, Southeast University from January 2019 to December 2021, and the clinical data of all patients were collected. Kidney disease quality of life-short form (KDQOL-SF) was applied to assess the health-related quality of life (HRQL) of the patients. The efficacy and QOL were compared between the patients receiving HFHD and those receiving HDF after propensity score matching(PSM). Results There were significant differences in scores of burden of kidney disease in kidney disease-targeted areas (KDTA) and scores of physical functioning, general health, and vitality of 36-item health survey (SF-36) (P<0.05). Conclusions In elderly MHD patients, disease burden caused by HDF is heavier than HFHD, but HDF can improve QOL -related physiological functions, general health and vitality. References | Related Articles | Metrics

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Application of multifunctional electronic sphygmomanometer in elderly patients with forearm hematoma during coronary intervention via radial artery ZHOU Xiao-ping, LIN Song, ZHU Xiao-min, ZHANG Jun-xia, QIAO Ji-min 2023, 37 (7):  746-749.  doi: 10.3969/j.issn.1003-9198.2023.07.023 Abstract ( 105 )   PDF (1171KB) ( 1036 )   Save Objective To explore the clinical effect of customized multifunctional electronic sphygmomanometer on forearm hematoma during percutaneous coronary intervention (PCI) via radial artery in the elderly patients. Methods A total of 110 elderly patients with forearm hematoma during PCI in our hospital from August 2019 to June 2022 were selected and divided into trial group and control group by random number table method, with 55 cases in each group. The forearm hematoma was compressed by local pressurization cuff of the multifunctional electronic sphygmomanometer in the trial group, while the forearm hematoma was compressed by mercury sphygmomanometer cuff in the control group. The comfortable degree of the patients, the operating frequency, operating time and radiation exposure dose of nurses during cuff compression, the successful rate of one-time hemostasis, the circumference of forearm and the degree of swelling were compared between the two groups. Results There was no statistically significant difference in comfortable degree between the two groups during the cuff compression (P>0.05). The frequency and the time of nurse's operation, and radiation exposure dose of the nurses were significantly different between the two groups (P<0.05). There were significant differences in the successful rate of one-time hemostasis, the circumference of forearm and the degree of swelling after compression between the two groups(P<0.05). Conclusions The local pressurization cuff by multifunctional electronic sphygmomanometer can reduce the operating frequency, operating time and radiation exposure dose of the nurses, and improve the successful rate of one-time hemostasis, without changing the comfortable degree of the patients receiving transradial PCI. References | Related Articles | Metrics