Abstract: Objective To explore the predictive efficacy of systemic immune-inflammation index(SII) and controlling nutritional status(CONUT) scores for the prognosis in the elderly patients with early distal gastric cancer undergoing total laparoscopic surgery. Methods From January 2019 to January 2022, a total of 126 elderly patients with early distal gastric cancer who underwent total laparoscopic gastrectomy in our hospital were enrolled. The peripheral blood platelet, lymphocyte count, neutrophil, serum albumin and total cholesterol levels were measured 3 days before the operation, and SII and CONUT score were calculated. According to the 6-month follow-up results, the subjects were divided into the good prognosis group and the poor prognosis group. Multivariate Logistic regression was used to analyze the relevant factors affecting the prognosis. The area under the receiver operating characteristic(ROC) curve(AUC) was used to evaluate the predictive value of SII and CONUT score for prognosis. Results Among 126 elderly patients with early distal gastric cancer, 24 presented with poor prognosis(18.75%). Multivariate Logistic regression analysis showed that older age, higher SII, higher CONUT score and M3 infiltrating muscularis mucosa were the risk factors for poor prognosis in the elderly patients with early distal gastric cancer. The results of ROC curve analysis showed that the AUC of SII and CONUT score alone and combination in predicting the prognosis was 0.706(95%CI: 0.610-0.852), 0.701(95%CI: 0.594-0.826) and 0.809(95%CI: 0.759-0.941) respectively, and the predicting efficiency of the two indexes was lower than that of the combination(P<0.05). Conclusions SII and CONUT score can be used to evaluate the prognosis of elderly patients with early distal gastric cancer.

Key words: early distal gastric cancer, aged, systemic immune-inflammation index, controlling nutritional status score