老年大疱性类天疱疮住院病人衰弱现状及影响因素分析

doi:10.3969/j.issn.1003-9198.2023.07.016

Abstract

Abstract: Objective To investigate the frailty status and influencing factors in the elderly inpatients with bullous pemphigoid(BP). Methods A total of 104 elderly inpatients with BP in Department of Dermatology and Venereology, West China Hospital of Sichuan University from August 2020 to February 2022 were selected by convenience sampling method. FRAIL Scale, Barthel Index, Nutrition Risk Screening 2002(NRS2002), and Pittsburgh Sleep Quality Index Scale(PSQI) were applied to evaluate the frailty condition, activities of daily living(ADL), nutritional risks and sleep quality of the elderly hospitalized patients with BP, and the general data, disease-related data and laboratory examination results were collected. Logistic regression was used to analyze the influencing factors of frailty. Results Among the elderly hospitalized patients with BP, 64 cases(61.5%) presented with frailty. Univariate analysis showed that the differences in age, body mass indes(BMI), comorbidities, bed rest, stroke history, coronary heart disease, chronic lung disease, lower limb venous thrombosis, hormonal therapy, the levels of anti-BP-180 antibody, ADL, NRS2002, hemoglobin, serum albumin, C-reactive protein(CRP),brain natriuretic peptide(BNP),glycosylated hemoglobin(HbA1c), total cholesterol and calcium ion between non-frailty/pre-frailty group and frailty group were statistically significant(P<0.05 or P<0.01). Logistic regression analysis showed that age(OR=1.248,95%CI:1.073-1.450)), ADL(OR=0.966,95%CI:0.939-0.993), anti-BP-180 antibody(OR=1.035,95%CI:1.018-1.052), CRP (OR=1.027,95%CI:1.005-1.048), BNP(OR=1.004,95%CI:1.001-1.007)were the influencing factors of frailty in the elderly patients with BP. Conclusions The incidence rate of frailty in the elderly hospitalized patients with BP is high. The elderly hospitalized patients with BP who are older, have decreased self-care ability, elevated anti-BP-180 antibody, elevated CRP and elevated BNP are more prone to presenting with frailty.

Key words: bullous pemphigoid, aged, frailty, influencing factor

CLC Number:

R 758.66

GOU Hui, XIANG Hong-mei, ZOU Qin, CHEN Ji-hui. Analysis of the frailty status and influencing factors in elderly inpatients with bullous pemphigoid[J]. Practical Geriatrics, 2023, 37(7): 714-718.

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Analysis of the frailty status and influencing factors in elderly inpatients with bullous pemphigoid

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