Abstract: Objective To observe the effect of glycopyrrolate on pulmonary function and pulmonary shunt in the elderly patients undergoing radical resection of lung cancer. Methods Ninety elderly patients undergoing radical resection of lung cancer were randomly divided into glycopyrrolate group (group G) and control group (group N), with 45 patients in each group. The patients in group G were intravenously injected with glycopyrrolate (5 μg/kg), while the patients in group N were intravenously injected with 0.9% sodium chloride 10 min before anesthesia induction. The hemodynamics of the patients were observed continuously at 6 time points, before anesthesia induction (T₀), two lung ventilation for 15 min after endotracheal intubation (T₁) and 15 min (T₂), 30 min (T₃), 40 min (T₄), 50 min (T₅) after one-lung ventilation. Airway resistance (Raw), pulmonary compliance (Comp) and peak airway pressure (Ppeak) were recorded at T₁, T₂, T₃, T₄ and T₅. Arterial blood and internal carotid venous blood were collected at T₁, T₂, and T₃ for blood gas analysis. PaO₂ and PaCO₂ were recorded, and the intrapulmonary shunt rate (Qs/Qt) was calculated. Results After one-lung ventilation, the level of PaO₂ decreased, and the levels of Qs/Qt, PaCO₂ increased at T₂ and T₃ (P＜0.05); The levels of Raw and Ppeak increased at T₂-T₅ (P＜0.05). Compared with group N, the level of Comp of group G was higher, and the level of Ppeak was lower at T₃-T₅, and the level of Qs/Qt was lower at T₂ and T₃ (P＜0.05). Conclusions Intravenous injection of glycopyrrolate can dilate bronchus, reduce intrapulmonary shunt, improve lung compliance, protect lung function without influencing the hemodynamics in the elderly patients undergoing radical resection of lung cancer.

Key words: glycopyrrolate, pulmonary function, pulmonary shunt, aged