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Research progress of calprotectin S100A8/S100A9 in Alzheimer's disease WU Jinli, YANG Xiaojuan Practical Geriatrics    2025, 39 (2): 197-201.   DOI: 10.3969/j.issn.1003-9198.2025.02.020 Abstract （48）      PDF （1039KB）（1399）       Alzheimer's disease(AD) is characterized by progressive memory loss. Based on the emerging theory of microbe-gut-brain axis, the changes in intestinal flora might activate the intestinal inflammation. Calprotectin, as a marker of intestinal inflammation, is a key substance in the brain-gut axis of AD. Its subunits S100A8 and S100A9 are also closely related to the Aβ theory and neuroinflammation theory in AD, respectively. Therefore, this article reviews the main functions of S100A8/S100A9 protein and its new research progress in AD-related pathogenesis, risk factors, prevention and treatment, in order to provide new research directions for the treatment of AD. Reference | Related Articles | Metrics

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Analysis of the current situation and influencing factors of demoralization syndrome in elderly patients with chronic heart failure GAO Wenjun, SUN Qing, LIU Mengtan, ZHOU Dan Practical Geriatrics    2024, 38 (11): 1105-1109.   DOI: 10.3969/j.issn.1003-9198.2024.11.006 Abstract （72）      PDF （1106KB）（1384）       Objective To investigate the current situation of demoralization syndrome in the elderly patients with chronic heart failure (CHF) and to analyze the influencing factors. Methods Convenience sampling method was used to enroll the elderly patients with CHF admitted to Changhai Hospital from June 2022 to June 2023 in this study. The patients were surveyed using a general information questionnaire, Chinese version of the Demoralization Scale-Ⅱ, Heart Failure Somatic Perception Scale (HFSPS), Fear of Progression Questionnaire-Short Form (FoP-Q-SF), International Physical Activity Questionnaire (IPAQ) and Perceived Social Support Scale (PSSS). Multiple linear regression was used to analyze the influencing factors of demoralization syndrome. Results The score of Demoralization Scale-Ⅱ in 245 elderly patients with CHF was 16.55±4.76, which was at a medium level. Pearson correlation analysis showed that demoralization syndrome was positively correlated with body perception, fear of disease progression and sedentary behavior (r=0.475, 0.440, 0.499, respectively), and negatively correlated with social support (r=-0.491). Multiple linear regression analysis showed that per capita monthly household income, disease duration, physical perception, fear of disease progression, sedentary behavior, and social support were independent influencing factors (P<0.05) for demoralization syndrome in the elderly patients with CHF, and could jointly explain 45.9% of the variation in demoralization syndrome. Conclusions The level of demoralization syndrome in the elderly patients with CHF is at a medium level. Low income, long course of disease, strong physical perception, high fear of disease progression and sedentary lifestyle were risk factors for the demoralization syndrome of patients with CHF, while social support is a protective factor. Reference | Related Articles | Metrics

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Practical Geriatrics    2024, 38 (8): 851-856.   DOI: 10.3969/j.issn.1003-9198.2024.08.022 Abstract （86）      PDF （1781KB）（1279）       Reference | Related Articles | Metrics

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Practical Geriatrics    2024, 38 (8): 770-774.   DOI: 10.3969/j.issn.1003-9198.2024.08.004 Abstract （95）      PDF （1174KB）（1239）       Reference | Related Articles | Metrics

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Practical Geriatrics    2024, 38 (9): 876-879.   DOI: 10.3969/j.issn.1003-9198.2024.09.004 Abstract （109）      PDF （1162KB）（1230）       Reference | Related Articles | Metrics

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Analysis of current situation and influencing factors of activities of daily living in the elderly with decreased subjective cognition in community YANG Cunmei, HU Yixin, LIU Cuie, MA Hongying, YAN Jin, XU Qiuli, XING Dan, ZHANG Tianyi Practical Geriatrics    2024, 38 (11): 1110-1115.   DOI: 10.3969/j.issn.1003-9198.2024.11.007 Abstract （53）      PDF （1174KB）（1193）       Objective To investigate the activities of daily living (ADL) of the community elderly with subjective cognitive decline (SCD) and to analyze the influencing factors. Methods Convenient sampling method was used to enroll a total of 459 elderly people in a community in Beijing from January 2019 to January 2022 in this study. The patients’ demographic data, anxiety and depression status, lifestyle, exercise style, nutrition, disease history and medication history were collected by self-designed questionnaire; And barthel index rating scale was used to evaluate the level of basic activities of daily living (BADL), Lawton instrumental activities of daily living (IADL) scale was used to evaluate the level of IADL. Univariate analysis and multivariate Logistic regression analysis were used to explore the influencing factors of ADL. Results A total of 209 cases (45.5%) presented with dependence on BADL, with a higher frequency of functional decline in ascending and descending stairs and urination; 256 cases (55.8%) presented with dependence on IADL; The frequency of functional decline is higher when going out, shopping and taking medication. Logistic regression analysis showed that age, decreased vision, BMI and physical activity time were the independent influencing factors of BADL dependence; Gender, hearing loss, anxiety, alcohol consumption, and nutrition were independent influencing factors of IADL dependence (P<0.05). Conclusions The incidence of ADL dependence in the elderly with SCD in community is high, but the degree is light; Community healthcare workers should focus on the elderly people being elderly, male, obesity, anxious, having decreased vision and hearing, having low physical activity, drinking alcohol, and having a risk of malnutrition, and should assist the elderly in establishing a healthy lifestyle to improve or delay their cognitive impairment. Reference | Related Articles | Metrics

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Practical Geriatrics    2024, 38 (9): 889-892.   DOI: 10.3969/j.issn.1003-9198.2024.09.007 Abstract （53）      PDF （1111KB）（1054）       Reference | Related Articles | Metrics

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Practical Geriatrics    2024, 38 (8): 766-769.   DOI: 10.3969/j.issn.1003-9198.2024.08.003 Abstract （97）      PDF （1118KB）（881）       Reference | Related Articles | Metrics

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Practical Geriatrics    2024, 38 (9): 872-875.   DOI: 10.3969/j.issn.1003-9198.2024.09.003 Abstract （56）      PDF （1099KB）（794）       Reference | Related Articles | Metrics

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Influence of exercise rehabilitation in elderly patients with mild to moderate chronic heart failure WANG Xiaojiao, WANG Ning, CUI Hong, YE Tong, WANG Xiaoming Practical Geriatrics    2024, 38 (8): 775-778.   DOI: 10.3969/j.issn.1003-9198.2024.08.005 Abstract （110）      PDF （1396KB）（757）       Objective To analyze the effect of exercise rehabilitation in the elderly patients with mild to moderate chronic heart failure(CHF). Methods From January 2020 to December 2022, 104 elderly patients with mild to moderate CHF (New York Heart Association cardiac function classification Ⅱ-Ⅲ grade) were randomly divided into two groups, with 52 cases in each group. The control group was given conventional anti-heart failure therapy, and the observation group was given standardized exercise load rehabilitation guidance based on the conventional anti-heart failure therapy. The changes of cardiac function, sleep quality, exercise tolerance, quality of life and the incidence rate of cardiovascular adverse events were observed and compared 6 months after discharge. Results The levels of left ventricular ejection fraction (LVEF), cardiac output (CO) and stroke volume (SV), the score of Minnesota Living with heart failure questionnaire (MLHFQ) and the 6-minute walk distance (6MWD) were significantly higher, while the score of Pittsburgh Sleep Quality Inventory (PSQI) and the incidence of adverse events 6 months after discharge were significantly lower in the observation group than those in the control group(P<0.05). The treadmill exercise time in the observation group was longer than that in the control group. With the extension of treadmill exercise time, acceleration of speed and increase of slope, the heart rate in the two groups was significantly increased, especially in the control group (P<0.05). Conclusions Standardized exercise load rehabilitation guidance can improve exercise tolerance and sleep quality of the elderly patients with mild to moderate CHF, which is worthy of clinical promotion. Reference | Related Articles | Metrics

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Effects of environmental exposure on cognitive impairment WANG Siya, YIN Shi Practical Geriatrics    2025, 39 (1): 22-25.   DOI: 10.3969/j.issn.1003-9198.2025.01.006 Abstract （51）      PDF （1121KB）（747）       In recent years, the impact of environmental exposure on human health, especially on cognitive impairment, has attracted increasing attention. This article reviews the influence of exposure to common air pollutants (including particulate matter, ozone, sulfur dioxide, nitrogen oxides, carbon monoxide, etc.) and metals (such as plumbum, cadmium, mercury, arsenic, etc.) in daily life and production on cognitive impairment, and investigates the related manifestations and potential mechanisms on cognitive impairment. Reference | Related Articles | Metrics

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Relationship between environmental exposure and sarcopenia DONG Xiaofei, ZHANG Fei, WANG Jiahe Practical Geriatrics    2025, 39 (1): 8-11.   DOI: 10.3969/j.issn.1003-9198.2025.01.003 Abstract （57）      PDF （1007KB）（716）       With the rapid development of society, the harm of environmental pollution has become increasingly prominent. With the progress of population aging, the prevelence of sarcopenia is increasing, which increases the national public health burden. This article reviews the effects and mechanisms of common environmental exposures such as air pollution, heavy metal exposure and noise pollution on sarcopenia, and elucidates that mitochondrial dysfunction and chronic inflammation caused by environmental pollution are closely related to the occurrence and progression of sarcopenia, and emphasizes the hazards of heavy metal exposure, in order to provide new ideas for the clinical diagnosis, treatment, and scientific research of sarcopenia. Reference | Related Articles | Metrics

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Practical Geriatrics    2024, 38 (8): 857-861.   DOI: 10.3969/j.issn.1003-9198.2024.08.023 Abstract （92）      PDF （1063KB）（704）       Reference | Related Articles | Metrics

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Effect of motor-cognitive dual task training on cognitive frailty in the elderly LAI Xiaoxing, CHEN Baoyu, LIU Xiaoxuan, LI Qi, ZHU Hongwei, HUO Xiaopeng Practical Geriatrics    2024, 38 (8): 821-825.   DOI: 10.3969/j.issn.1003-9198.2024.08.015 Abstract （106）      PDF （1085KB）（697）       Objective To explore the effect of motor-cognitive dual task training in the elderly patients with cognitive frailty. Methods A total of 72 elderly people with cognitive frailty meeting the inclusion criteria were enrolled and randomly divided into intervention group and control group, with 36 cases in each group. The control group was given health education about cognitive frailty, while the intervention group received motor-cognitive dual task training for 16 weeks in addition. The frailty status, cognitive and motor function before and after intervention in the two groups were assessed and compared. Results Before intervention, there were no significant differences in the general information, scores of Tilburg frailty indicator (TFI), Montreal Cognitive Assessment(MoCA), Performance Oriented Mobility Assessment (POMA)and time up and go test(TUGT) between the two groups(P>0.05). After intervention, the score of TFI and the time of TUGT were significantly lower and the scores of MoCA and POMA were significantly higher in intervention group than those in control group (P<0.05). Conclusions Motor-cognitive dual task training can effectively improve the frailty, cognitive and physical function of the elderly with cognitive frailty, and it is suitable to popularize in the elderly with cognitive frailty. Reference | Related Articles | Metrics

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Practical Geriatrics    2024, 38 (8): 761-765.   DOI: 10.3969/j.issn.1003-9198.2024.08.002 Abstract （153）      PDF （1207KB）（678）       Reference | Related Articles | Metrics

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Practical Geriatrics    2024, 38 (9): 867-871.   DOI: 10.3969/j.issn.1003-9198.2024.09.002 Abstract （67）      PDF （1033KB）（659）       Reference | Related Articles | Metrics

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Practical Geriatrics    2024, 38 (8): 757-760.   DOI: 10.3969/j.issn.1003-9198.2024.08.001 Abstract （202）      PDF （1183KB）（647）       Reference | Related Articles | Metrics

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Predictive value of plasma N-terminal pro-brain natriuretic peptide for prognosis in patients aged ≥80 years old with left ventricular hypertrophy LI Huiying, CAI Lili, ZHU Qiwei Practical Geriatrics    2024, 38 (8): 797-801.   DOI: 10.3969/j.issn.1003-9198.2024.08.010 Abstract （77）      PDF （1089KB）（632）       Objective To explore the predictive value of N-terminal pro-brain natriuretic peptide (NT-proBNP) for the prognosis in the elderly patients aged≥80 years old with left ventricular hypertrophy(LVH). Methods A total of 309 elderly patients aged ≥80 years old with LVH admitted to the Second Medical Center of the General Hospital of the People’s Liberation Army were enrolled in the study. The clinical baseline data, biochemistry index and the plasma level of NT-proBNP were collected. All-cause death and major adverse cardiovascular events (MACEs) of the patients were followed up. Linear regression was used to screen the clinical factors related to NT-proBNP. Cox risk proportional regression model was used to evaluate the relationship between NT-proBNP level and endpoint events. Receiver operating characteristic (ROC) curve wad used to evaluate the predictive value of NT-proBNP for the prognosis in the elderly patients with LVH. Results The median NT-proBNP level of 309 patients was 325 (144,821) pg/mL. The plasma level of NT-proBNP was positively correlated with aging, atrial fibrillation, pacemaker implantation, left ventricular mass index (LVMI) and the use of β-blockers, while negatively correlated with estimated glomerular filtration rate (eGFR), hemoglobin, plasma albumin and left ventricular ejection fraction(LVEF). A median follow-up of 6.7 (3.1,9.1) years showed 239(77.3%) cases of death and 117(37.9%) cases of MACEs. The multivariate Cox regression model showed that the highest percentile group of NT-proBNP had a significantly increased risk of all-cause death (HR= 3.029; 95% CI: 1.918-4.728) and MACEs (HR =3.173; 95% CI: 1.612-6.244) compared to the lowest percentile group. ROC curve analysis showed that the AUC of NT-proBNP in predicting all-cause death and MACEs was 0.669 and 0.594 respectively(P<0.01). Conclusions Plasma NT-proBNP has independent predictive value for all-cause death and MACEs in the elderly patients aged≥80 years old with LVH. Reference | Related Articles | Metrics

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Effect of low-dose lidocaine combined with propofol on motor evoked potential in elderly patients undergoing intracranial tumor resection LIU Meijuan, WANG Ning, WANG Dong, LU Fangzhou, LIU Juan Practical Geriatrics    2024, 38 (8): 808-811.   DOI: 10.3969/j.issn.1003-9198.2024.08.012 Abstract （79）      PDF （1100KB）（585）       Objective To investigate the effect of low-dose lidocaine combined with propofol on motor evoked potential(MEP) in the elderly patients undergoing intracranial tumor resection. Methods A total of 44 elderly patients receiving intracranial tumor resection monitored by MEP under general anesthesia were enrolled in this study, and were divided into lidocaine group (group L) and control group (group C) by random number table method, with 22 cases in each group.All patients were anesthetized with propofol. The patients in group L received low-dose lidocaine additionally, while the patients in group C was given equal amount of normal saline. The mean arterial pressure(MAP), heart rate(HR), depth of anesthesia, MEP amplitude and latency, propofol dosage and the occurrence of adverse reactions were recorded and compared between the two groups at different time during anesthesia. Results The levels of HR and MAP at different time showed statistically significant differences in group C (P<0.05), while showing no significant differences in group L(P>0.05). During anesthesia, there were no significant differences in MEP amplitude and latency between the two groups (P>0.05), but the dosage of propofol and the incidence rate of adverse reactions in group L were significantly lower than those in group C (P<0.05). Conclusions Low-dose lidocaine has no significant effect on the amplitude and latency of MEP in the elderly patients undergoing surgery for intracranial tumor, which is conductive to maintain hemodynamic stability, reduce intraoperative propofol dosage and the incidence of adverse reactions. Reference | Related Articles | Metrics

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Practical Geriatrics    2024, 38 (10): 973-973.   DOI: 10.3969/j.issn.1003-9198.2024.10.001 Abstract （108）      PDF （1167KB）（560）       Reference | Related Articles | Metrics

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Impacts of pentoxifylline combined with lipoic acid intervention on physical function and quality of life in elderly patients with frailty syndrome LI Jingbing, WANG Huijun, WANG Shaoying, ZHAO Can, WANG Lidi, CAO Yujiao Practical Geriatrics    2024, 38 (8): 812-815.   DOI: 10.3969/j.issn.1003-9198.2024.08.013 Abstract （94）      PDF （1057KB）（539）       Objective To analyze the impacts of pentoxifylline combined with lipoic acid on physical function and quality of life in the elderly patients with frailty syndrome. Methods A total of 120 elderly patients with frailty syndrome admitted into our hospital from February 2020 to February 2022 were enrolled in this study, and all patients were divided to the single-drug group (n=60) and the combination group (n=60) according to random number table method. The single-drug group was treated with lipoic acid, and the combination group was given lipoic acid combined with pentoxifylline. The frailty was assessed by the Clinical Frailty Scale (Fried). The physical function was evaluated by Tinetti-Balance and Gait Scale (Tinetti-POMA) and the activities of daily living (ADL) scale, and the quality of life was assessed by MOS 36-Item Short Form Health Survey (SF-36).The efficacy, grip strength and pace speed before and after the intervention, and the incidence rate of adverse effects were observed and compared between the two groups. Results After the intervention, the Fried score was significantly decreased, and the grip strength, pace speed, scores of Tinetti-POMA, ADL scale and SF-36 were significantly increased in the two group, especially in the combination group (P<0.05). The safety indexes before and after treatment were all within the range of clinical normal values in the two groups, and there was no statistical difference in the incidence rate of adverse reactions between the two groups (P>0.05). Conclusions Pentoxifylline combined with lipoic acid can effectively and safely improve the physical function and quality of life of the elderly patients with frailty syndrome. Reference | Related Articles | Metrics

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Practical Geriatrics    2024, 38 (10): 1074-1077.   DOI: 10.3969/j.issn.1003-9198.2024.10.024 Abstract （70）      PDF （1059KB）（539）       Reference | Related Articles | Metrics

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Relationship of ApoB/ApoA1 ratio and triglyceride glucose index with severity and prognosis of traumatic brain injury in the elderly LI Guangyao, YE Bihua, LI Xiaoliang, TANG Qin, LIU Cuihua Practical Geriatrics    2024, 38 (10): 1049-1053.   DOI: 10.3969/j.issn.1003-9198.2024.10.018 Abstract （69）      PDF （1320KB）（527）       Objective To investigate the relationship of apolipoprotein B (ApoB)/apolipoprotein A1 (ApoA1) ratio, triglyceride-glucose (TyG) index with the severity and prognosis of traumatic brain injury (TBI) in the elderly. Methods A retrospective study was conducted. A total of 112 patients with TBI (TBI group) and 79 healthy volunteers (control group) in Mianyang Central Hospital from January 2018 to January 2023 were selected. The patients with TBI were divided into moderate group (64 cases) and severe group (48 cases) according to the score of Glasgow Outcome Scale (GCS) at admission. The neurological prognosis was assessed by Glasgow Prognosis Scale (GOS) 6 months after discharge. According to GOS score, the patients with TBI were divided into poor prognosis group (23 cases) and good prognosis group (89 cases). The clinical data were collected, and ApoB/ApoA1 ratio and TyG index were calculated. Pearson correlation analysis was used to analyze the correlation of ApoB/ApoA1 ratio and TyG index with insulin resistance (HOMA-IR) and GCS score, and multivariate Logistic regression analysis was conducted to analyze the factors affecting the prognosis of TBI. Receiver operating characteristic (ROC) curve analysis was used to analyze the value of ApoB/ApoA1 ratio and TyG index in predicting prognosis of TBI. Results ApoB/ApoA1 ratio, TyG index and HOMA-IR in TBI group were significantly higher than those in control group (P < 0.05), and were significantly higher in severe group than those in moderate group (P < 0.05). The ApoB/ApoA1 ratio and TyG index were negatively correlated with GCS score (P < 0.05), and positively correlated with HOMA-IR in the patients with TBI (P < 0.05). Ventricular hemorrhage, high ApoB/ApoA1 ratio, high TyG index and high HOMA-IR were risk factors for poor prognosis in TBI patients (P < 0.05). The area under the curve of ApoB/ApoA1 ratio and TyG index in predicting the prognosis of TBI was 0.744 and 0.755, which was close to HOMA-IR (0.794, P>0.05); The area under the curve of combination of ApoB/ApoA1 ratio, TyG index and HOMA-IR in predicting the prognosis of TBI patients was 0.888, which was higher than them alone (P < 0.05). Conclusions Increased ApoB/ApoA1 ratio and TyG index in the elderly patients with TBI are associated with aggravated nerve injury and poor prognosis. Detection of ApoB/ApoA1 ratio and TyG index is helpful to assess the risk of poor prognosis in the elderly patients with TBI. Reference | Related Articles | Metrics

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Correlation between preoperative SII/ALB and clinicopathologic features in elderly patients with lung adenocarcinoma LI Jiang, QIU Yan, WANG Ting, WANG Dan, YU Yifan, PU Lingli, BU Ling Practical Geriatrics    2024, 38 (9): 893-896.   DOI: 10.3969/j.issn.1003-9198.2024.09.008 Abstract （67）      PDF （1035KB）（525）       Objective To investigate the correlation between preoperative systemic immunoinflammatory index/serum albumin (SII/ALB) and clinicopathological features in the elderly patients with lung adenocarcinoma. Methods The clinicopathological data of 103 elderly patients with lung adenocarcinoma treated by thoracoscopic surgery in Geriatric Hospital of Nanjing Medical University from January 2020 to June 2023 were retrospectively analyzed. SII/ALB value was calculated according to preoperative test results, and the patients were divided into high SII/ALB group and low SII/ALB group according to the median SII/ALB value. The relationship between SII/ALB and clinicopathological features of the patients was analyzed. Results The median SII/ALB was 16.1, and there were 47 cases in low SII/ALB group (SII/ALB≤16.1) and 56 cases in high SII/ALB group (SII/ALB > 16.1). There were significant differences in BMI, high-grade adenocarcinoma components, pleural invasion, TNM stage, lymph node metastasis and airway spread between the two groups (P<0.05). The level ofSII/ALB was correlated with TNM stage and lymph node metastasis (P<0.05). Conclusions SII/ALB reflects the immune, inflammatory and nutritional status of the patients. SII/ALB level is related to TNM stage and lymph node metastasis. Monitoring SII/ALB level is helpful to provide certain reference information for the clinical diagnosis and treatment of elderly lung adenocarcinoma. Reference | Related Articles | Metrics

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Effects of alexithymia and social support on anhedonia and depressive symptoms in elderly patients with late-life depression ZHANG Jian, JIANG Chenguang, YUAN Yonggui Practical Geriatrics    2024, 38 (10): 997-1001.   DOI: 10.3969/j.issn.1003-9198.2024.10.007 Abstract （91）      PDF （1115KB）（514）       Objective To investigate the effects of alexithymia and social support on anhedonia and depressive symptoms in the elderly patients with late-life depression (LLD). Methods A total of 216 elderly LLD patients aged ≥60 years who visited Psychosomatic Medicine Department of Zhongda Hospital, Southeast University, from 2020 to 2023 were assessed using the 17-item Hamilton Depression Rating Scale (HAMD-17), the Snaith-Hamilton Pleasure Scale (SHAPS), the Toronto Alexithymia Scale (TAS), and the Social Support Rating Scale (SSRS).The relationships of the variables were explored by Pearson correlation analysis. The structural equation model (SEM) containing alexithymia, social support, anhedonia and depressive symptoms was constructed and analyzed by path analysis. Results The score of TAS was positively correlated with the scores of HAMD-17(r=0.294, P<0.001) and SHAPS (r=0.455, P<0.001), and negatively correlated with the score of SSRS (r=-0.210, P=0.002). The score of SSRS was negatively correlated with the scores of HAMD-17 (r=-0.299, P<0.001) and SHAPS (r=-0.230, P=0.001). The path analysis showed that the more severe alexithymia,the more severe depressive symptoms and anhedonia, while lower level of social support was associated with more severe alexithymia, depressive symptoms, and anhedonia. The final model showed good fit (χ2=0.211, df=1, χ2/df=0.211, RMSEA<0.001, CFI=1.000, GFI=1.000). Conclusions Enhancing social support can mitigate alexithymia and depressive symptoms, thereby improving the overall psychological health of LLD patients. Reference | Related Articles | Metrics

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Correlation of triglyceride-glucose index with low-density lipoprotein subtypes in elderly patients with type 2 diabetes mellitus WANG Su, ZHAO Yijing, WEI Chenmin, CHEN Kun, CAO Wen, WANG Kun, YANG Yu Practical Geriatrics    2024, 38 (10): 1002-1006.   DOI: 10.3969/j.issn.1003-9198.2024.10.008 Abstract （100）      PDF （1271KB）（514）       Objective To investigate the correlation between triglyceride-glucose (TyG) index and low-density lipoprotein (LDL) subtypes in the elderly patients with type 2 diabetes mellitus (T2DM). Methods The clinical data of 360 elderly T2DM patients admitted to Affiliated Jiangning Hospital of Nanjing Medical University from January 2022 to March 2023 were analyzed retrospectively. The correlation between TyG index and LDL subtypes was analyzed, and the cut-off value of elevated small dense low-density lipoprotein cholesterol (sdLCL-C) level was defined by receiver operating characteristic (ROC) curve analysis. Results All patients were divided into 4 groups according to the quartiles of TyG index level. The level of TyG index was positively correlated with LDL-C3, LDL-C4, LDL-C5, LDL-C6 and LDL-C7 (P<0.01), and negatively correlated with LDL-C1 and LDL-C2 (P<0.01). Logistic regression analysis showed a significant positive correlation between TyG index level and high sdLDL-C level. The cut-off value of TyG index to predict the occurrence of high sdLDL-C was 9.0, and the area under the curve was 0.70. Conclusions In the elderly patients with T2DM, TyG index is closely related to sdLDL-C level, which may be a simple and feasible clinical indicator to recognize the increase of the level of sdLDL-C. Reference | Related Articles | Metrics

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Practical Geriatrics    2024, 38 (9): 884-888.   DOI: 10.3969/j.issn.1003-9198.2024.09.006 Abstract （55）      PDF （1042KB）（503）       Reference | Related Articles | Metrics

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Practical Geriatrics    2024, 38 (10): 974-978.   DOI: 10.3969/j.issn.1003-9198.2024.10.002 Abstract （98）      PDF （1138KB）（500）       Reference | Related Articles | Metrics

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Practical Geriatrics    2024, 38 (10): 979-982.   DOI: 10.3969/j.issn.1003-9198.2024.10.003 Abstract （95）      PDF （1162KB）（493）       Reference | Related Articles | Metrics

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Effective dose of remimazolam to inhibit cardiovascular response to double-lumen tracheal intubation in elderly patients ZHONG Zhigang, CHEN Jing Practical Geriatrics    2024, 38 (11): 1101-1104.   DOI: 10.3969/j.issn.1003-9198.2024.11.005 Abstract （76）      PDF （1745KB）（489）       Objective To investigate the effective dose of remimazolam to inhibit the cardiovascular response to double-lumen endotracheal intubation during general anesthesia with sufentanil in the elderly patients who receiving thoracic non-cardiac surgery. Methods In this study, 21 elderly patients who underwent double-lumen tracheal intubation during thoracic non-cardiac surgery under general anesthesia were selected from October 2022 to April 2023, and the sequential method was used in this study. The first patient received intravenous injection of remimazolam 0.3 mg/kg, and the dose of remimazolam for the next patient was determined according to the cardiovascular response to tracheal intubation of the previous patient. If the cardiovascular response was positive, the dose was increased by 0.01 mg/kg; Instead, the dose of the next patient was decreased by 0.01 mg/kg, and the experiment was terminated when there were ≥6 consecutive alternating positive and negative waveforms. The Probit method was used to calculate the median effective dose (ED50) and the 90% effective dose (ED90) of remimazolam in inhibiting the cardiovascular response to double-lumen tracheal intubation. Results A total of 10 positive and 11 negative cases were observed in 21 patients. The ED50 of remimazolam combined with sufentanil in suppressing the cardiovascular response to double-lumen tracheal intubation during thoracic non-cardiac surgery in the elderly patients was 0.306 mg/kg, with a 95%CI of 0.291-0.328 mg/kg, and the ED90 was 0.322 mg/kg, with a 95%CI of 0.312-0.488 mg/kg. Conclusions The ED50 of remimazolam in inhibiting cardiovascular response to double-lumen endotracheal intubation was 0.306 mg/kg and the ED90 was 0.322 mg/kg in the elderly patients who underwent thoracic surgery under general anesthesia with sufentanil. Reference | Related Articles | Metrics