ApoB/ApoA1比值、甘油三酯-葡萄糖指数与老年创伤性脑损伤严重程度和预后的关系

doi:10.3969/j.issn.1003-9198.2024.10.018

Abstract

Abstract: Objective To investigate the relationship of apolipoprotein B (ApoB)/apolipoprotein A1 (ApoA1) ratio, triglyceride-glucose (TyG) index with the severity and prognosis of traumatic brain injury (TBI) in the elderly. Methods A retrospective study was conducted. A total of 112 patients with TBI (TBI group) and 79 healthy volunteers (control group) in Mianyang Central Hospital from January 2018 to January 2023 were selected. The patients with TBI were divided into moderate group (64 cases) and severe group (48 cases) according to the score of Glasgow Outcome Scale (GCS) at admission. The neurological prognosis was assessed by Glasgow Prognosis Scale (GOS) 6 months after discharge. According to GOS score, the patients with TBI were divided into poor prognosis group (23 cases) and good prognosis group (89 cases). The clinical data were collected, and ApoB/ApoA1 ratio and TyG index were calculated. Pearson correlation analysis was used to analyze the correlation of ApoB/ApoA1 ratio and TyG index with insulin resistance (HOMA-IR) and GCS score, and multivariate Logistic regression analysis was conducted to analyze the factors affecting the prognosis of TBI. Receiver operating characteristic (ROC) curve analysis was used to analyze the value of ApoB/ApoA1 ratio and TyG index in predicting prognosis of TBI. Results ApoB/ApoA1 ratio, TyG index and HOMA-IR in TBI group were significantly higher than those in control group (P < 0.05), and were significantly higher in severe group than those in moderate group (P < 0.05). The ApoB/ApoA1 ratio and TyG index were negatively correlated with GCS score (P < 0.05), and positively correlated with HOMA-IR in the patients with TBI (P < 0.05). Ventricular hemorrhage, high ApoB/ApoA1 ratio, high TyG index and high HOMA-IR were risk factors for poor prognosis in TBI patients (P < 0.05). The area under the curve of ApoB/ApoA1 ratio and TyG index in predicting the prognosis of TBI was 0.744 and 0.755, which was close to HOMA-IR (0.794, P>0.05); The area under the curve of combination of ApoB/ApoA1 ratio, TyG index and HOMA-IR in predicting the prognosis of TBI patients was 0.888, which was higher than them alone (P < 0.05). Conclusions Increased ApoB/ApoA1 ratio and TyG index in the elderly patients with TBI are associated with aggravated nerve injury and poor prognosis. Detection of ApoB/ApoA1 ratio and TyG index is helpful to assess the risk of poor prognosis in the elderly patients with TBI.

Key words: traumatic brain injury, insulin resistance, triglyceride-glucose index, apolipoprotein B, apolipoprotein A1, prognosis

CLC Number:

R 651.1

LI Guangyao, YE Bihua, LI Xiaoliang, TANG Qin, LIU Cuihua. Relationship of ApoB/ApoA1 ratio and triglyceride glucose index with severity and prognosis of traumatic brain injury in the elderly[J]. Practical Geriatrics, 2024, 38(10): 1049-1053.

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Relationship of ApoB/ApoA1 ratio and triglyceride glucose index with severity and prognosis of traumatic brain injury in the elderly

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