系统免疫炎症指数、白蛋白、甲胎蛋白与老年胃腺癌肝转移病人预后的相关性研究

doi:10.3969/j.issn.1003-9198.2024.04.012

Abstract

Abstract: Objective To explore the correlation of systemic immune inflammation index (SII), albumin (ALB) and alpha-fetoprotein (AFP) with the prognosis in the elderly patients with liver metastasis from gastric adenocarcinoma. Methods A total of 94 elderly inpatients with gastric adenocarcinoma and liver metastasis from October 2019 to October 2022 were enrolled in this study and followed up to February 2023. The clinical data of all patients were collected, and blood routine [hemoglobin (Hb), peripheral blood plate (PLT), neutrophil (NC), lymphocyte count (LY)], liver and kidney function [ALB, prealbumin (PALB)], coagulation function (D-dimer) and related tumor markers [AFP, carcinoembryonic antigen (CEA), carbohydrate antigen 199 (CA199), carbohydrate antigen 125 (CA125)]were detected and SII was caculated. Kaplan-Meier survival curve and Cox regression analysis were used to analyze the influencing factors of the prognosis in the elderly patients with liver metastasis from gastric adenocarcinoma. Results The follow-up time of all patients was 4.4-33.5 months, with a median follow-up time of 12.7 months. The 1-year and 2-year survival rates of the elderly patients with liver metastasis from gastric adenocarcinoma were 57.41% and 6.38% respectively. Univariate Cox regression analysis showed that age, marital status, histological grade, treatment style, the levels of SII, ALB, PALB, AFP and CA199 were correlated with the prognosis in the elderly patients with gastric adenocarcinoma and hepatic metastasis (P<0.05). Multivariate Cox regression analysis showed that chemotherapy combined with local treatment, low level of SII, high level of ALB and low level of AFP were protective factors of the prognosis in the elderly patients with gastric adenocarcinoma and liver metastasis (P<0.05). Kaplan-Meier survival curve showed that the median survival time of the patients with chemotherapy combined with local therapy, low SII, high ALB, and low AFP was significantly longer than that in the patients with other therapeutic interventions, high level of SII, low level of ALB and high level of AFP (all P<0.05), respectively. Conclusions The levels of SII, ALB and AFP are associated with the prognosis, and may be good prognostic indicators in the elderly patients with liver metastasis from gastric adenocarcinoma.

Key words: gastric adenocarcinoma, liver metastasis, prognosis, aged, systemic immune-inflammation index, albumin, alpha-fetoprotein

CLC Number:

R 735.2

HU Yun, WANG Shuhong, XU Ji. Relationship of systemic immune-inflammation index, albumin, alpha-fetoprotein with prognosis in elderly patients with liver metastasis from gastric adenocarcinoma[J]. Practical Geriatrics, 2024, 38(4): 377-381.

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Relationship of systemic immune-inflammation index, albumin, alpha-fetoprotein with prognosis in elderly patients with liver metastasis from gastric adenocarcinoma

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