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Clinical effect and influencing factors of intravenous thrombolysis with ateplase in patients with acute cerebral infarction aged 80 years and over LI Yin-zhen, ZHANG Jing-wen, ZHENG Yong-qiang Practical Geriatrics    2021, 35 (5): 463-466.   DOI: 10.3969/j.issn.1003-9198.2021.05.008 Abstract （268）      PDF （4255KB）（9069）       Objective To investigate the clinical efficacy, safety and influencing factors of intravenous thrombolysis with ateplase (rt-PA) in the elderly patients with acute cerebral infarction. Methods A total of 117 patients with acute cerebral infarction with onset time less than 4.5 hours admitted to our hospital from January 2017 to October 2020 were retrospectively analyzed, including 81 males and 36 females. According to age, 83 patients were assigned in control group (＜80 years old) and 34 patients in observation group(≥80 years old). All patients of the two groups were given intravenous thrombolysis with 0.9 mg/kg rt-PA. The acute efficacy [improvement of National Institute of Health stroke scale (NIHSS) score within 14 days], short-term efficacy (Modified Rankin Scale score within 90 days) and safety of rt-PA in the two groups were compared. The influencing factors for the prognosis of intravenous thrombolysis were analyzed by multiple Logistic regression. Results There were no significant differences in curative effect, the incidence rate of complications induced by thrombolysis and mortality after thrombolytic therapy between the two groups (P>0.05). The incidence rate of complications not induced by thrombolysis in observation group was higher than that in control group (20.59% vs 6.02%, P=0.018). Based on multiple Logistic regression analysis, NIHSS score before thrombolysis and complications not inducecd by thrombolysis were independent risk factors for the clinical outcome of intravenous thrombolysis after 90 days. Conclusions Using rt-PA in the thrombolytic time window of the elderly patients with acute cerebral infarction is safe and effective. The score of NIHSS before thrombolysis and complications not induced by thrombolysis shows effects on the prognosis of the patients with acute cerebral infarction aged 80 years old and over. Reference | Related Articles | Metrics

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Practical Geriatrics    2023, 37 (10): 1076-1080.   DOI: 10.3969/j.issn.1003-9198.2023.10.026 Abstract （141）      PDF （999KB）（6364）       Reference | Related Articles | Metrics

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Practical Geriatrics    2024, 38 (1): 72-76.   DOI: 10.3969/j.issn.1003-9198.2024.01.017 Abstract （123）      PDF （1101KB）（6140）       Reference | Related Articles | Metrics

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Practical Geriatrics    2010, 24 (1): 13-.   Abstract （875）      PDF （1278KB）（10682）       Related Articles | Metrics

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XU Qian, LI Qian-Qian, DAN An-Xia, LIU Cun-Zhi Practical Geriatrics    2015, 29 (6): 511-.   Abstract （163）      PDF （928KB）（5455）       Related Articles | Metrics

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Practical Geriatrics    2023, 37 (9): 878-881.   DOI: 10.3969/j.issn.1003-9198.2023.09.004 Abstract （113）      PDF （1042KB）（4906）       Reference | Related Articles | Metrics

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Practical Geriatrics    2023, 37 (10): 978-983.   DOI: 10.3969/j.issn.1003-9198.2023.10.002 Abstract （118）      PDF （1157KB）（4764）       Reference | Related Articles | Metrics

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Practical Geriatrics    2024, 38 (1): 68-71.   DOI: 10.3969/j.issn.1003-9198.2024.01.016 Abstract （110）      PDF （1122KB）（3028）       Reference | Related Articles | Metrics

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Research progress of calprotectin S100A8/S100A9 in Alzheimer's disease WU Jinli, YANG Xiaojuan Practical Geriatrics    2025, 39 (2): 197-201.   DOI: 10.3969/j.issn.1003-9198.2025.02.020 Abstract （48）      PDF （1039KB）（1399）       Alzheimer's disease(AD) is characterized by progressive memory loss. Based on the emerging theory of microbe-gut-brain axis, the changes in intestinal flora might activate the intestinal inflammation. Calprotectin, as a marker of intestinal inflammation, is a key substance in the brain-gut axis of AD. Its subunits S100A8 and S100A9 are also closely related to the Aβ theory and neuroinflammation theory in AD, respectively. Therefore, this article reviews the main functions of S100A8/S100A9 protein and its new research progress in AD-related pathogenesis, risk factors, prevention and treatment, in order to provide new research directions for the treatment of AD. Reference | Related Articles | Metrics

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Practical Geriatrics    2024, 38 (9): 889-892.   DOI: 10.3969/j.issn.1003-9198.2024.09.007 Abstract （53）      PDF （1111KB）（1054）       Reference | Related Articles | Metrics

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LV Li-Wei Practical Geriatrics    2010, 24 (3): 181-.   Abstract （1062）      PDF （1007KB）（6597）       Related Articles | Metrics

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Practical Geriatrics    2024, 38 (2): 193-197.   DOI: 10.3969/j.issn.1003-9198.2024.02.021 Abstract （110）      PDF （1061KB）（2322）       Reference | Related Articles | Metrics

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Analysis of the current situation and influencing factors of demoralization syndrome in elderly patients with chronic heart failure GAO Wenjun, SUN Qing, LIU Mengtan, ZHOU Dan Practical Geriatrics    2024, 38 (11): 1105-1109.   DOI: 10.3969/j.issn.1003-9198.2024.11.006 Abstract （72）      PDF （1106KB）（1384）       Objective To investigate the current situation of demoralization syndrome in the elderly patients with chronic heart failure (CHF) and to analyze the influencing factors. Methods Convenience sampling method was used to enroll the elderly patients with CHF admitted to Changhai Hospital from June 2022 to June 2023 in this study. The patients were surveyed using a general information questionnaire, Chinese version of the Demoralization Scale-Ⅱ, Heart Failure Somatic Perception Scale (HFSPS), Fear of Progression Questionnaire-Short Form (FoP-Q-SF), International Physical Activity Questionnaire (IPAQ) and Perceived Social Support Scale (PSSS). Multiple linear regression was used to analyze the influencing factors of demoralization syndrome. Results The score of Demoralization Scale-Ⅱ in 245 elderly patients with CHF was 16.55±4.76, which was at a medium level. Pearson correlation analysis showed that demoralization syndrome was positively correlated with body perception, fear of disease progression and sedentary behavior (r=0.475, 0.440, 0.499, respectively), and negatively correlated with social support (r=-0.491). Multiple linear regression analysis showed that per capita monthly household income, disease duration, physical perception, fear of disease progression, sedentary behavior, and social support were independent influencing factors (P<0.05) for demoralization syndrome in the elderly patients with CHF, and could jointly explain 45.9% of the variation in demoralization syndrome. Conclusions The level of demoralization syndrome in the elderly patients with CHF is at a medium level. Low income, long course of disease, strong physical perception, high fear of disease progression and sedentary lifestyle were risk factors for the demoralization syndrome of patients with CHF, while social support is a protective factor. Reference | Related Articles | Metrics

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Practical Geriatrics    2024, 38 (2): 109-113.   DOI: 10.3969/j.issn.1003-9198.2024.02.001 Abstract （173）      PDF （1278KB）（3698）       Reference | Related Articles | Metrics

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Practical Geriatrics    2024, 38 (4): 334-337.   DOI: 10.3969/j.issn.1003-9198.2024.04.003 Abstract （103）      PDF （1197KB）（2169）       Reference | Related Articles | Metrics

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Practical Geriatrics    2024, 38 (3): 299-303.   DOI: 10.3969/j.issn.1003-9198.2024.03.021 Abstract （90）      PDF （1073KB）（2366）       Reference | Related Articles | Metrics

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Practical Geriatrics    2024, 38 (2): 119-122.   DOI: 10.3969/j.issn.1003-9198.2024.02.003 Abstract （155）      PDF （1125KB）（2633）       Reference | Related Articles | Metrics

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Practical Geriatrics    2024, 38 (9): 876-879.   DOI: 10.3969/j.issn.1003-9198.2024.09.004 Abstract （109）      PDF （1162KB）（1230）       Reference | Related Articles | Metrics

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Practical Geriatrics    2024, 38 (3): 232-235.   DOI: 10.3969/j.issn.1003-9198.2024.03.005 Abstract （113）      PDF （1157KB）（2562）       Reference | Related Articles | Metrics

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Analysis of current situation and influencing factors of activities of daily living in the elderly with decreased subjective cognition in community YANG Cunmei, HU Yixin, LIU Cuie, MA Hongying, YAN Jin, XU Qiuli, XING Dan, ZHANG Tianyi Practical Geriatrics    2024, 38 (11): 1110-1115.   DOI: 10.3969/j.issn.1003-9198.2024.11.007 Abstract （53）      PDF （1174KB）（1193）       Objective To investigate the activities of daily living (ADL) of the community elderly with subjective cognitive decline (SCD) and to analyze the influencing factors. Methods Convenient sampling method was used to enroll a total of 459 elderly people in a community in Beijing from January 2019 to January 2022 in this study. The patients’ demographic data, anxiety and depression status, lifestyle, exercise style, nutrition, disease history and medication history were collected by self-designed questionnaire; And barthel index rating scale was used to evaluate the level of basic activities of daily living (BADL), Lawton instrumental activities of daily living (IADL) scale was used to evaluate the level of IADL. Univariate analysis and multivariate Logistic regression analysis were used to explore the influencing factors of ADL. Results A total of 209 cases (45.5%) presented with dependence on BADL, with a higher frequency of functional decline in ascending and descending stairs and urination; 256 cases (55.8%) presented with dependence on IADL; The frequency of functional decline is higher when going out, shopping and taking medication. Logistic regression analysis showed that age, decreased vision, BMI and physical activity time were the independent influencing factors of BADL dependence; Gender, hearing loss, anxiety, alcohol consumption, and nutrition were independent influencing factors of IADL dependence (P<0.05). Conclusions The incidence of ADL dependence in the elderly with SCD in community is high, but the degree is light; Community healthcare workers should focus on the elderly people being elderly, male, obesity, anxious, having decreased vision and hearing, having low physical activity, drinking alcohol, and having a risk of malnutrition, and should assist the elderly in establishing a healthy lifestyle to improve or delay their cognitive impairment. Reference | Related Articles | Metrics

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Practical Geriatrics    2024, 38 (3): 223-227.   DOI: 10.3969/j.issn.1003-9198.2024.03.003 Abstract （123）      PDF （1187KB）（2004）       Reference | Related Articles | Metrics

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Practical Geriatrics    2024, 38 (4): 399-404.   DOI: 10.3969/j.issn.1003-9198.2024.04.017 Abstract （92）      PDF （1094KB）（1402）       Reference | Related Articles | Metrics

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Practical Geriatrics    2023, 37 (5): 528-531.   DOI: 10.3969/j.issn.1003-9198.2023.05.023 Abstract （101）      PDF （1008KB）（1951）       Reference | Related Articles | Metrics

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Effects of environmental exposure on cognitive impairment WANG Siya, YIN Shi Practical Geriatrics    2025, 39 (1): 22-25.   DOI: 10.3969/j.issn.1003-9198.2025.01.006 Abstract （51）      PDF （1121KB）（747）       In recent years, the impact of environmental exposure on human health, especially on cognitive impairment, has attracted increasing attention. This article reviews the influence of exposure to common air pollutants (including particulate matter, ozone, sulfur dioxide, nitrogen oxides, carbon monoxide, etc.) and metals (such as plumbum, cadmium, mercury, arsenic, etc.) in daily life and production on cognitive impairment, and investigates the related manifestations and potential mechanisms on cognitive impairment. Reference | Related Articles | Metrics

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Practical Geriatrics    2024, 38 (8): 851-856.   DOI: 10.3969/j.issn.1003-9198.2024.08.022 Abstract （86）      PDF （1781KB）（1279）       Reference | Related Articles | Metrics

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Practical Geriatrics    2024, 38 (4): 405-409.   DOI: 10.3969/j.issn.1003-9198.2024.04.018 Abstract （81）      PDF （1075KB）（1464）       Reference | Related Articles | Metrics

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Practical Geriatrics    2024, 38 (1): 3-6.   DOI: 10.3969/j.issn.1003-9198.2024.01.002 Abstract （163）      PDF （1125KB）（1541）       Reference | Related Articles | Metrics

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Practical Geriatrics    2023, 37 (10): 1041-1043.   DOI: 10.3969/j.issn.1003-9198.2023.10.016 Abstract （93）      PDF （1199KB）（2385）       Reference | Related Articles | Metrics

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Practical Geriatrics    2024, 38 (4): 330-333.   DOI: 10.3969/j.issn.1003-9198.2024.04.002 Abstract （153）      PDF （1106KB）（1608）       Reference | Related Articles | Metrics

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Practical Geriatrics    2024, 38 (8): 770-774.   DOI: 10.3969/j.issn.1003-9198.2024.08.004 Abstract （95）      PDF （1174KB）（1239）       Reference | Related Articles | Metrics