老年肌少症人群中血浆褪黑素水平变化的临床分析

doi:10.3969/j.issn.1003-9198.2024.05.008

Abstract

Abstract: Objective To investigate the level and the clinical significance of plasma level of melatonin in the elderly patients with sarcopenia. Methods A case-control study was conducted. Forty elderly patients with sarcopenia (≥60 years old) who visited Department of Geriatrics, the First Hospital of Lanzhou University from December 2022 to May 2023 were enrolled in the sarcopenia group. Forty elderly patients without sarcopenia in the same period were enrolled in the control group with gender 1∶1 matching condition. The basic clinical data, sarcopenia-related indicators, routine laboratory indicators and plasma level of melatonin were collected and compared between the two groups. Pearson correlation analysis was used to evaluate the correlation between plasma level of melatonin and sarcopenia-related indicators. Multivariate Logistic regression analysis was performed to analyze the independent influencing factors of sarcopenia. And receiver operating characteristic (ROC) curve was used to evaluate the value of melatonin in predicting sarcopenia. Results The plasma level of melatonin in the sarcopenia group was significantly lower than that in the control group(P＜0.01). Plasma level of melatonin was positively correlated with appendicular skeletal muscle index (ASMI) (r=0.520,P＜0.01). Conditional Logistic regression analysis showed that plasma level of melatonin was an independent protective factor for sarcopenia(OR=0.807,P=0.017). ROC curve showed that the best cut-off value of plasma melatonin level in predicting sarcopenia was 3.2 ng/L, with sensitivity of 76.7%, specificity of 68.3%, and the area under the ROC curve was 0.715(P＜0.01). Conclusions The level of plasma melatonin in the elderly patients with sarcopenia is significantly decreased, which can be used as a potential biomarker for sarcopenia.

Key words: sarcopenia, aged, melatonin, biomarker

CLC Number:

R 685

ZHOU Lingshan, ZHANG Haiyan, LUO Yin, AO Xiaojun, LIU Rong, YANG Yuan, QIAO Chengdong. Clinical analysis of the plasma level of melatonin in the elderly patients with sarcopenia[J]. Practical Geriatrics, 2024, 38(5): 465-437.

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Clinical analysis of the plasma level of melatonin in the elderly patients with sarcopenia

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