Practical Geriatrics ›› 2024, Vol. 38 ›› Issue (6): 557-563.doi: 10.3969/j.issn.1003-9198.2024.06.005

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A Meta-analysis on the efficacy of His-Purkinje system pacing in elderly patients with pacing-induced cardiomyopathy

CHENG Rong, ZHOU Haoyang, LI Ying, ZHANG Cheng, LI Chunyu, CHEN Yan   

  1. Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou 215000,China (CHENG Rong, ZHOU Haoyang, LI Ying, CHEN Yan);
    Central Laboratory(ZHANG Cheng); Intensive Care Unit(LI Chunyu), Longjiang Branch of the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
  • Received:2024-02-20 Online:2024-06-20 Published:2024-06-19
  • Contact: CHEN Yan,Email: chenyandoc@njmu.edu.cn

Abstract: Objective To evaluate the efficacy and clinical benefit of upgrading to His-Purkinje system conduction system pacing (HPCSP) in the elderly patients with pacing-induced cardiomyopathy (PICM) after right ventricular pacing (RVP). Methods The literatures on Hirsch-Purkinje system (Hirsch-Purkinje system) pacing in the patients with PICM were searched from PubMed, Cochrane Library, Web of Science, Embase, CNKI, Wanfang Data and VIP Database, based on inclusion and exclusion criteria. The relevant data on clinical efficacy and safety were extracted from the studies, and were analyzed by RevMan 5.4 software. Results A total of 8 literatures were enrolled in this study, and 185 patients were included. The successful rate of HPCSP was 95%. The results of Meta-analysis showed that, compared with baseline, patients’ left ventricular ejection fraction(MD=-11.73, 95%CI:-14.74--8.72, P<0.01)was significantly increased, QRS duration(MD=59.84, 95%CI:55.98-63.70, P<0.01)was shortened, cardiac function classification of New York Heart Association(MD=1.05, 95%CI: 0.70-1.41, P<0.01)was significantly increased. No significant differences were observed in pacing threshold (MD=-0.11, 95%CI: -0.24-0.02, P=0.08) and R-wave(MD=-0.35, 95%CI: -1.94-1.24, P=0.66) before and after the upgrading operation. Conclusions For the elderly patients with PICM, upgrading the pacing mode to HPCSP should be considered. HPCSP can correct electrical dissynchronization and ventricular remodeling caused by long-term right ventricular pacing, and can improve clinical cardiac function and reduce surgery-related complications.

Key words: His-Purkinje conduction system pacing, His bundle pacing, left bundle branch pacing, pacing-induced cardiomyopathy, aged, right ventricular pacing, Meta-analysis

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