Abstract: Objective To evaluate the application of modified frailty index(mFI) in predicting the complications after robot-assisted radical prostatectomy in the elderly patients. Methods A retrospective analysis was performed on the clinical data of 100 patients who underwent robot-assisted radical prostatectomy in the Second Affiliated Hospital of Xi 'an Jiaotong University from June 2019 to October 2022. According to mFI score, the patients were divided into the frailty group (mFI≥0.27) and the non-frailty group (mFI<0.27).The differences in general clinical data, mFI score and the incidence of postoperative complications between the two groups were analyzed. Multivariate Logistic regression analysis was performed to explore the risk factors of postoperative complications. Results A total of 100 patients meeting the criteria were enrolled in this study, including 37 cases in the frailty group and 63 cases in the non-frailty group. There were statistically significant differences in American Society of Anesthesiologists(ASA) grading and age between the two groups (P<0.05). The incidence rates of the complications in cardiovascular system, respiratory system and nervous system in frailty group were significantly higher than those in the non-frailty group (P<0.01). Multivariate Logistic regression analysis showed that the frailty was the independent risk factors for the complications in cardiovascular system (OR=7.344, 95%CI:1.196-45.093, P=0.031), respiratory system (OR=5.849, 95%CI: 1.668-20.507, P=0.006) and nervous system (OR=5.521, 95%CI:1.686-18.083, P=0.005). Conclusions mFI score can be used as an effective tool to evaluate the frailty state of the elderly patients undergoing robot-assisted radical prostatectomy. The patients with mFI≥0.27 have an increased risk of postoperative multisystem complications.

Key words: modified frailty index, postoperative complications, aged, prostate cancer