C-反应蛋白/白蛋白比值联合中性粒细胞/淋巴细胞比值对膀胱癌根治术老年病人并发术后认知功能障碍的预测价值

doi:10.3969/j.issn.1003-9198.2023.11.011

Abstract

Abstract: Objective To investigate the predictive value of C-reactive protein to albumin ratio(CAR) combined with neutrophil to lymphocyte ratio(NLR) for postoperative cognitive dysfunction(POCD) in the elderly patients undergoing radical cystectomy for bladder cancer. Methods A total of 660 elderly patients who underwent radical cystectomy for bladder cancer in our hospital from January 2019 to October 2022 were enrolled in this study, and the patients were divided into the POCD group(n=182) and the non-POCD group(n=478) according to whether they presented with POCD. The basic clinical data of the patients were collected, and the levels of CAR and NLR were compared between the two groups. The influencing factors of POCD in the elderly patients undergoing radical cystectomy for bladder cancer were analyzed by Logistic regression model. Receiver operating characteristic(ROC) curve was used to analyze the predictive value of CAR, NLR and their combination for POCD in the elderly patients undergoing radical cystectomy for bladder cancer. Results There were significant difference in age, smoking, cerebrovascular disease, proportion of preoperative Mini Mental State Examination(MMSE) score <26 and operation time≥3 hours, and the levels of CAR and NLR between the POCD group and the non-POCD group(P＜0.05 or P＜0.01). Multivariate Logistic regression analysis showed that elevated CAR and NLR were independent risk factors for POCD in the elderly patients undergoing radical cystectomy for bladder cancer after adjusting other influencing factors. According to ROC curve analysis,the area under curve (AUC) of the combined detection of CAR and NLR in predicting POCD in the elderly patients undergoing radical cystectomy for bladder cancer was 0.894, which was significantly higher than that of CAR alone(AUC=0.787) or NLR alone(AUC=0.811), respectively, with statistically significant differences(P<0.01). Conclusions CAR combined with NLR has a high predictive value for POCD in the elderly patients undergoing radical cystectomy for bladder cancer.

Key words: aged, radical cystectomy for bladder cancer, postoperative cognitive dysfunction, C-reactive protein to albumin ratio, neutrophil to lymphocyte ratio, predictive value

CLC Number:

R 737.14

LIANG An-shi, XIE Cai-ye. Predictive value of C-reactive protein to albumin ratio combined with neutrophil to lymphocyte ratio for postoperative cognitive dysfunction in elderly patients undergoing radical cystectomy for bladder cancer[J]. Practical Geriatrics, 2023, 37(11): 1125-1129.

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Predictive value of C-reactive protein to albumin ratio combined with neutrophil to lymphocyte ratio for postoperative cognitive dysfunction in elderly patients undergoing radical cystectomy for bladder cancer

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