生长分化因子15和细胞因子对老年冠心病合并衰弱病人的诊断价值

doi:10.3969/j.issn.1003-9198.2023.10.008

Abstract

Abstract: Objective To investigate the diagnostic value of growth differentiation factor 15 (GDF15) and cytokines in the elderly patients with coronary heart disease (CHD) complicated with frailty. Methods A total of 88 elderly CHD patients treated at the Affiliated Hospital of Xuzhou Medical University from July to September 2022 were enrolled in this study. According to the Frail scale, the patients were divided into the frailty group (27 cases) and the non-frailty group (61 cases). The general data, serum levels of GDF15 and cytokines of the two groups were detected and compared. The receiver operating characteristic(ROC)curve was used to analyze the diagnostic value of GDF15 and cytokines for frailty in the elderly patients with CHD. Results The age, age-adjusted Charlson comorbidity index (ACCI) and the levels of GDF15, interleukin-1β(IL-1β), IL-5, IL-6, IL-10, interferon-α(IFN-α), IFN-γ and tumor necrosis factor-α(TNF-α) in the frailty group were significantly higher than those in the non-frailty group (P＜0.05). The area under the ROC curve (AUC) showed that the combined diagnosis of IFN-α, IFN-γ and GDF15 for frailty in the elderly CHD patients was superior to the diagnostic value of each single indicator (P＜0.05). Conclusions IFN-α, IFN-γ and GDF15 can serve as diagnostic indicators for frailty in the elderly CHD patients, and the efficacy of the combination of three indicators is higher.

Key words: aged, coronary heart disease, frailty, growth differentiation facor 15, cytokines, diagnostic value

CLC Number:

R 541.4

YANG Xue, NING Chun, ZHAO Juan, HAO Jing-bo, YANG Rong-li. Diagnostic value of growth differentiation factor 15 and cytokines in elderly patients with coronary heart disease complicated with frailty[J]. Practical Geriatrics, 2023, 37(10): 1009-1013.

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Diagnostic value of growth differentiation factor 15 and cytokines in elderly patients with coronary heart disease complicated with frailty

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