Abstract: Objective To investigate the correlation between osteoporosis and serum levels of leptin, adiponectin and chemokine in the elderly. Methods A total of 72 elderly patients with osteoporosis were selected as the study subjects who were admitted to our hospital from September 2016 to February 2019, and 65 elderly cases with normal bone mass were selected as control group who underwent physical examination in our hospital during the same period. The serum levels of leptin, adiponectin, chemokine, bone mineral density(BMD) of lumbar 1-4,BMD of left hip joint and related biochemical indexes were detected and compared between the two groups. Results The levels of chemokine and adiponectin in osteoporosis group were higher than those in control group, while the level of leptin was lower than that in control group (P <0.05). Pearson correlation analysis showed that serum levels of chemokine and adiponectin were negatively correlated with BMD of lumbar spine and hip in osteoporosis group (r=-0.630, r=-0.569, P<0.01; r=-0.275, r=-0.197, P<0.01). The level of leptin was positively correlated with BMD of lumbar spine and hip(r=0.428, r=0.332, P<0.05 or P <0.01). Multivariate Logistic regression analysis showed that the serum level of chemokine increased the risk of osteoporosis after adjusting age, sex and body mass index(OR=1.25, 95%CI:1.09-1.43). The level of leptin reduced the risk of osteoporosis(OR=0.21, 95%CI:0.07-0.65). Adiponectin was not associated with osteoporosis obviously(OR=1.03, 95%CI:0.96-1.12). Conclusions The serum level of chemokine is positively correlated with the occurrence of osteoporosis in the elderly, which is a risk factor of osteoporosis and may be a predictor of the potential risk of osteoporosis. The serum level of leptin is negatively correlated with the risk of osteoporosis in the elderly, which may play a protective role in the development of osteoporosis and provide theoretical basis for clinical prevention and treatment of osteoporosis in the elderly.

Key words: aged, osteoporosis, bone mineral density, leptin, adiponectin, chemokine