Abstract: Objective To investigate the relationship of pulmonary hypertension (PH) and hypercoagulability with serum adiponectin and 8-iso prostaglandin F_2α in the elderly patients with chronic obstructive pulmonary disease (COPD). Methods A total of 132 COPD patients at stable period were enrolled in this study. The patients were divided into COPD group (56 cases) and COPD combined with PH group(76 cases) according to whether pulmonary artery systolic pressure (PASP) was ≥40 mmHg measured by echocardiography. The age, gender, smoking history, body mass index (BMI) and forced expiratory volume in the first second accounted for the percentage of forced vital capacity (FEV1/FVC) were collected. Serum levels of adiponectin and 8-iso prostaglandin F_2α were measured by enzyme linked immunosorbent assay. The levels of fibrinogen (FIB) and D-dimer (D-D) were also detected. Results There were no significant differences in age, gender, smoking history, BMI, blood pressure, blood glucose and blood lipid between the two groups (P>0.05). COPD with PH group had higher levels of 8-iso prostaglandin F_2α, D-D, FIB and lower levels of FEV1/FVC and adiponectin than those in the COPD group(all P<0.05). After adjustment for age, gender, BMI, FEV1/FVC and other confounding factors by Logistic regression, adiponectin had negative effect and 8-iso prostaglandin F_2α had postive effect on PH (all P<0.05). In the COPD combined with PH group, FIB and D-D were negatively related to adiponectin, while positively related to 8-iso prostaglandin F_2α (all P<0.05). Conclusions The levels of adiponectin and oxidative stress are closely related to PH and hypercoagulability in the elderly patients with COPD complicated with PH.

Key words: chronic obstructive pulmonary disease, pulmonary hypertension, adiponectin, 8-iso prostaglandin F_2α, hypercoagulable state