Abstract: Objective To investigate the effects of ipratropium bromide combined with low molecular weight heparin calcium on the cardiac function, pulmonary function and myocardial enzymogram in the elderly patients with chronic obstructive pulmonary disease (COPD) combined with pulmonary heart disease (PHD). Methods A total of 80 patients with COPD combined with PHD admitted to our hospital from January 2019 to July 2020 were prospectively enrolled, and were divided into control group and study group by random number table method, with 40 cases in each group. The control group was treated with ipratropium bromide, while the study group was treated with ipratropium bromide combined with low molecular weight heparin calcium. The heart function, lung function, serum levels of creatine kinase (CK) and CK-MB of the two groups were compared before and after treatment. The effective rate and the incidence rate of adverse reactions were observed and compared between the two groups. Results The effective rate of the study group was significantly higher than that of the control group (97.50% vs 77.5%, χ²=7.314, P<0.01). After treatment, the levels of end-diastolic ventricular volume (EDV), end-systolic ventricular volume (ESV), CK and CK-MB in both groups were significant lower, and the levels of right ventricular ejection fraction (RVEF), forced expiratory volume in the first second (FEV1)/forced vital capacity (FVC), FVC and peak expiratory flow (PEF) in both groups were significantly higher than those before treatment, especially in the study group (P＜0.05). There was no significant difference in the incidence rate of adverse reactions between the two groups (χ²=0.220, P=0.823). Conclusions Ipratropium bromide combined with low molecular weight heparin calcium is effective in the treatment of the elderly patients with COPD and PHD, which can improve their heart function and lung function, and significantly reduce the levels of CK and CK-MB.

Key words: ipratropium bromide, low molecular weight heparin calcium, chronic obstructive pulmonary disease, pulmonary heart disease, creatine kinase, aged