Abstract: Objective To explore the relationship between blood pressure parameters and renal dysfunction in the elderly male patients with CKD and hypertension. Methods The elderly male patients with CKD at stage 3-4 and hypertension in our hospital from January 2015 to December 2019 were selected. The clinical laboratory data and 24 h ambulatory blood pressure in two years were recorded in a row. The patients were divided into two groups according to eGFR decline [the level of eGFR decreased >8 mL/(min·1. 73m²)in two years]. The data of stable renal function group and progressive renal function group were statistically analyzed. Results The baseline level of renal function in the stable renal function group was lower than that in the progressive renal function group (P<0. 05), but there was no significant difference in other clinical data (P>0. 05); There was no significant difference in the observed parameters of renal function between the two groups two years later (P>0. 05). Compared with stable renal function group, the status of hypertension control in progressive renal function group was worse, especially in SBP(P<0. 05). Conclusions High blood pressure variability is common in the elderly male patients with CKD and hypertension. Poor control of SBP may be one of the main reasons for the renal progression.

Key words: chronic kidney disease, hypertension, blood pressure variability, aged, renal dysfunction