Abstract: Objective To investigate the clinical effect of fibrobronchoscope Olympus BF40 combined with isoniazid injection in the elderly patients with bronchial tuberculosis and its influence on the inflammatory factors and pulmonary function. Methods A total of 122 elderly patients with bronchial tuberculosis who were treated from January 2017 to December 2018 were selected and divided into control group (n=61) and observation group (n=61) according to the treatment methods. The control group was given 3HRZE/9HRE treatment, and the observation group was treated with fibrobronchoscope Olympus BF40 combined with isoniazid injection on the basis of the control group. After 6 months of treatment, the rate of sputum negative conversion, the levels of inflammatory factors and lung function of the two groups were compared. Results The sputum negative conversion rates of the observation group were 80. 33% and 91. 80% 3 months and 6 months after treatment, compared with 62. 30% and 73. 77% in the control group respectively. The level of interferon-γ in the observation group was higher, and the levels of CRP and IL-6 were lower than those in the control group (P<0. 01); The levels of forced expiratory volume in one second (FEV1), FEV1/forced vital capacity (FVC) and maximal voluntary ventilation (MVV) of the observation group were higher than those of the control group 6 months after treatment (P<0. 01). There was no significant difference in the incidence rate of adverse events between the two groups (χ²=1. 291, P=0. 536). Conclusions Olympus BF40 combined with isoniazid injection in the elderly patients with bronchial tuberculosis is helpful to improve the negative conversion rate of sputum bacteria, improve the levels of inflammatory factors and pulmonary function, which is worthy of promotion and application.

Key words: isoniazid injection, bronchial tuberculosis, sputum negative rate, inflammatory factor, lung function, aged