Practical Geriatrics ›› 2025, Vol. 39 ›› Issue (7): 654-658.doi: 10.3969/j.issn.1003-9198.2025.07.002

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Research progress on the association between inflammation and sarcopenia in the elderly

YI Xinmei, ZHANG Fei, WANG Jiahe   

  1. Department of Family Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, China
  • Received:2025-04-11 Online:2025-07-20 Published:2025-07-22
  • Contact: WANG Jiahe, Email: wangjhcmusj@163.com

Abstract: Sarcopenia is a geriatric syndrome characterized by the decline in muscle mass, strength, and function associated with aging. It severely affects the quality of life of the elderly and increases the risk of various adverse health outcomes. Changes in hormone levels, mitochondrial dysfunction, degeneration of neuromuscular junctions, insufficient nutritional intake, lack of physical activity, chronic diseases, etc. are all related to the occurrence of sarcopenia. Among them, inflammation plays a crucial role in the occurrence and development of sarcopenia. This article reviews the research progress on the relationship between inflammation and sarcopenia, aiming to deeply understand the interaction between inflammation and sarcopenia, and provide a reference for the development of effective prevention and treatment measures.

Key words: sarcopenia, inflammation, comorbidity, aged

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