Practical Geriatrics ›› 2025, Vol. 39 ›› Issue (6): 543-546.doi: 10.3969/j.issn.1003-9198.2025.06.002

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Research progress on inflammation and sleep disorders

WANG Qi, WANG Zhe, WANG Yuehui   

  1. Geriatrics Department, Jilin University First Hospital, Jilin Provincial Clinical Medical Research Center for Geriatric Diseases, Changchun 130021, China
  • Received:2025-04-10 Online:2025-06-20 Published:2025-07-07
  • Contact: WANG Yuehui, Email: yuehuiwang300@jlu.edu.cn

Abstract: Sleep disorders widely affect adults globally, being particularly prominent among the elderly. There is a complex bidirectional relationship between sleep disorders and inflammation, which has a profound impact on human health. This article delves into the interaction mechanisms between sleep disorders and inflammation. It separately describes the effects of sleep disorders on inflammatory factors, such as activating inflammatory signaling pathways and leading to an increase in inflammatory factors, as well as the impact of inflammation on sleep, like interfering with sleep structure and patterns. Innovatively, it is proposed to regulate sleep-immune function through drug and behavioral interventions to break the vicious cycle between sleep disorders and inflammation, thereby improving sleep disorders and slowing down disease progression. Future research should focus on the molecular mechanisms of the interaction between sleep disorders and inflammation to provide a theoretical basis for the development of more precise and effective intervention measures. In clinical treatment, it is recommended to incorporate the treatment of sleep disorders and inflammation into a comprehensive treatment plan to improve patients’ quality of life and to reduce disease risks.

Key words: sleep disorders, inflammation, correlation study

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