低灌注强度比值联合系统免疫炎症指数对老年缺血性卒中病人溶栓后早期神经功能恶化的预测价值

doi:10.3969/j.issn.1003-9198.2024.06.013

Abstract

Abstract: Objective To investigate the predictive value of hypoperfusion intensity ratio (HIR) combined with systemic immune-inflammation index (SII) for the occurrence of early neurological deterioration (END) in the elderly patients with acute ischemic stroke (AIS) after thrombolysis. Methods A total of 185 patients with AIS admitted to Department of Emergency of Nanjing Drum Tower Hospital from January 2020 to December 2022 were retrospectively enrolled in this study, and they were divided into END group and non-END group. The baseline data of the two groups were statistically analyzed. Logistic regression model was used to analyze the risk factors for the occurrence of END. The predictive value of HIR and SII for END in the elderly patients with AIS was analyzed by using receiver operating characteristics (ROC) curve. Results There were 41 patients presenting with END, with an incidence rate of 22.2%. The levels of HIR and SII, National Institutes of Health Stroke Scale (NIHSS) score at admission and blood glucose in END group were significantly higher than those in non-END group (P<0.05); Logistic regression analysis showed that higher HIR (OR=1.065, 95% CI: 1.038-1.092), higher SII (OR=1.001, 95% CI: 1.000-1.001), higher NIHSS score at admission (OR=1.063, 95% CI: 1.003-1.127) and higher blood glucose (OR=1.186, 95% CI: 1.039-1.354) were the independent risk factors for the development of END in elderly AIS patients (P <0.05). The results of the ROC curve analysis of the indicators predicting the occurrence of END in the elderly patients with AIS showed that the AUC of HIR, SII, NIHSS score, blood glucose and HIR combined with SII at admission were 0.861, 0.658, 0.728, 0. 665, and 0. 885. Conclusions HIR and SII have important influences on the occurrence of END in the elderly patients with AIS, and the combined detection of HIR and SII has a higher predictive value for the occurrence of END.

Key words: acute ischemic stroke, hypoperfusion intensity ratio, early neurological deterioration, systemic-immune inflammation index, predictive value

CLC Number:

R743.33

YOU Jiaxiang, LI Xiaoxi, XIA Jun, LI Haopeng, WANG Jun. Predictive value of hypoperfusion intensity ratio combined with systemic immune-inflammation index for early neurological deterioration after thrombolysis in elderly patients with acute ischemic stroke[J]. Practical Geriatrics, 2024, 38(6): 598-602.

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Predictive value of hypoperfusion intensity ratio combined with systemic immune-inflammation index for early neurological deterioration after thrombolysis in elderly patients with acute ischemic stroke

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