农村老年人维生素D水平与自身免疫性甲状腺炎的横断面研究

doi:10.3969/j.issn.1003-9198.2025.05.005

Abstract

Abstract: Objective To explore the prevalence of autoimmune thyroiditis (AIT) in rural elderly and to analyze the correlation between serum vitamin D level and AIT. Methods The research subjects were derived from the study of Thyroid Diseases in Older Population: Screening, Surveillance, and Intervention (TOPS study) from May to July 2021 in iodine-adequate areas of Jiangsu Province. A total of 2460 elderly aged ≥65 years were enrolled. The general data including age, gender, height and weight were collected, and relevant laboratory indicators such as thyrotropin (TSH), thyroglobulin antibody (TgAb), thyroid peroxidase antibody (TPOAb), urinary iodine, blood glucose, blood lipids, and serum 25(OH)D were detected. The prevalence characteristics of AIT was analyzed, and a binary logistic regression model was established to analyze the correlation between serum 25(OH)D level and AIT. Results Among 2460 participants, 290 cases presented with AIT (11.79%). The prevalence rate of AIT in women was significantly higher than that in men (15.14% vs 8.55%, P<0.001). The median 25(OH)D level in the participants was 30.80 ng/mL. Women had a significantly lower median 25(OH)D level than men (25.80 ng/mL vs 36.00 ng/mL, P<0.001). Additionally, the elderly with AIT had a significantly lower median 25(OH)D level than those without AIT (28.40 ng/mL vs 31.15 ng/mL, P<0.001). In the elderly rural women, serum 25(OH)D level was an independent risk factor for AIT (OR=0.980, 95%CI: 0.961－0.998), but serum 25(OH)D level was not associated with AIT in the elderly rural men. Conclusions There is a correlation between vitamin D level and AIT in the elderly rural women.

Key words: autoimmune thyroiditis, vitamin D, female, aged

CLC Number:

R 581.4

ZHANG Jie, WANG Qifeng, MI Weinuo, ZHANG Lina, GHEN Guofang, SUN Yu, XU Shuhang, LIU Chao. The level of vitamin D and the prevalence of autoimmune thyroiditis in rural elderly: a cross-sectional study[J]. Practical Geriatrics, 2025, 39(5): 456-460.

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The level of vitamin D and the prevalence of autoimmune thyroiditis in rural elderly: a cross-sectional study

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