血浆降钙素基因相关肽水平预测老年原发性高血压病人血压晨峰现象的价值

doi:10.3969/j.issn.1003-9198.2025.05.013

Abstract

Abstract: Objective To investigate the value of plasma calcitonin gene-related peptide (CGRP) for predicting morning blood pressure surge (MBPS) after medication in the elderly patients with primary hypertension. Methods A total of 112 elderly hospitalized patients with primary hypertension were enrolled in this study.According to the 24 h ambulatory blood pressure monitoring (ABPM) results after medication, the patients were divided into non-morning peak group (MBPS＜35 mmHg, 53 cases) and morning peak group (MBPS≥35 mmHg, 59 cases). In addition, 14 elderly patients with normal blood pressure were enrolled as control group. The clinical data were collected, and the plasma level of CGRP was detected and compared among the three groups. The related factors of MBPS≥35 mmHg after clinical medication in the elderly patients with primary hypertension were analyzed by binary logistic regression, and receiver operating characteristic (ROC) curve was drawn to analyze the predictive value of plasma CGRP for MBPS≥35 mmHg. Results The levels of CGRP, clinic systolic blood pressure (SBP), 24-hour SBP (24hSBP), daytime SBP (dSBP), morning SBP and morning diastolic blood pressure (DBP) in morning peak group were significantly higher than those in control group and non-morning peak group (P＜0.05). And the prevalence of diabetes in morning peak group was significantly higher than that in non-morning peak group (P＜0.05). Binary logistic regression analysis showed that CGRP, morning SBP and 24hSBP were the independent influencing factors for MBPS≥35 mmHg after clinical medication in the elderly patients with primary hypertension (P＜0.05). ROC curve analysis showed that the area under the curve of CGRP combined with morning SBP, and 24hSBP for predicting MBPS≥35 mmHg after clinical medication in the elderly patients with primary hypertension was 0.819, and the cut-off value of CGRP was 89.52 pg/mL. Conclusions Plasma CGRP combined with morning SBP and 24hSBP can predict the occurrence of MBPS≥35 mmHg after clinical medication in the elderly patients with primary hypertension.

Key words: aged, primary hypertension, calcitonin gene-related peptide, morning blood pressure surge

CLC Number:

R 544.1

HUANG Yuanjie, HUA Dongxu, SUN Jingxian, GU Mingxia, SUN Wei, WANG Lan. Predictive value of plasma calcitonin gene-related peptide level for morning blood pressure surge in elderly patients with primary hypertension[J]. Practical Geriatrics, 2025, 39(5): 497-501.

References

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Predictive value of plasma calcitonin gene-related peptide level for morning blood pressure surge in elderly patients with primary hypertension

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