老年T2DM病人肌少症与肺功能的相关性研究

doi:10.3969/j.issn.1003-9198.2025.07.009

Abstract

Abstract: Objective To investigate the correlation between sarcopenia and lung function in the elderly patients with type 2 diabetes mellitus (T2DM). Methods A total of 250 elderly T2DM patients treated in the Geriatric Department of Huai’an First People’s Hospital from January 2023 to September 2024 were enrolled in this study. Based on the presence of sarcopenia, the subjects were divided into sarcopenia group(75 cases) and non-sarcopenia group (175 cases). The differences in general data, related indexes of muscle measurements and lung function were compared between the two groups. Correlation analysis was performed to investigate the factors associated with lung function in the elderly T2DM patients. Results The levels of walking speed and grip strength, body mass index (BMI), hemoglobin, lymphocyte count, forced expiratory volume in 1 second (FEV1), and FEV1/ forced vital capacity (FVC) in sarcopenia group were significantly lower than those in non-sarcopenia group (P<0.05). The duration of T2DM, and the levels of fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c) and alanine aminotransferase (ALT) were significantly higher than those in non-sarcopenia group (P<0.05). In sarcopenia group, FEV1 and FEV1/FVC showed significant negative correlations with age and T2DM duration (P<0.05), while showing positive correlations with BMI, grip strength, gait speed, and muscle mass (0.5<r<0.8, P<0.05). In non-sarcopenia group, FEV1 and FEV1/FVC were weakly correlated with grip strength, gait speed, and muscle mass (0.3<r<0.5, P<0.05). Multivariate linear regression analysis showed that age, duration of T2DM, and sarcopenia were independent factors associated with FEV1 and FEV1/FVC in the elderly T2DM patients. Conclusions The risk of lung function decline in the elderly T2DM patients with sarcopenia is higher than that in non-sarcopenia patients. Early screening and effective intervention for sarcopenia are crucial for preventing and managing pulmonary dysfunction complications in the elderly T2DM patients.

Key words: type 2 diabetes mellitus, sarcopenia, lung function, correlation

CLC Number:

R685

ZHANG Shaohong, ZHANG Ling, WANG Mengxi, SUN Mengyue, LU Peng,ZHAO Songqing, WANG Weimin. Relationship of sarcopenia with lung function in elderly patients with type 2 diabetes mellitus[J]. Practical Geriatrics, 2025, 39(7): 693-697.

References

[1] ASSOCIATION A D. 12. older adults: standards of medical care in diabetes-2019[J]. Diabetes Care, 2019, 42(Suppl 1): S139-S147.
[2] KIRKMAN M S, BRISCOE V J, CLARK N, et al. Diabetes in older adults[J]. Diabetes Care, 2012, 35(12): 2650-2664.
[3] IZZO A, MASSIMINO E, RICCARDI G, et al. A narrative review on sarcopenia in type 2 diabetes mellitus: prevalence and associated factors[J]. Nutrients, 2021, 13(1): 183.
[4] GEA J, PASCUAL S, CASADEVALL C, et al. Muscle dysfunction in chronic obstructive pulmonary disease: update on causes and biological findings[J]. J Thorac Dis, 2015, 7(10): E418-E438.
[5] CHEN L K, WOO J, ASSANTACHAI P, et al. Asian working group for sarcopenia: 2019 consensus update on sarcopenia diagnosis and treatment[J]. J Am Med Dir Assoc, 2020, 21(3): 300-307. e2.
[6] 刘娟, 丁清清, 周白瑜, 等. 中国老年人肌少症诊疗专家共识(2021)[J]. 中华老年医学杂志, 2021, 40(8): 943-952.
[7] WANG T, FENG X, ZHOU J, et al. Type 2 diabetes mellitus is associated with increased risks of sarcopenia and pre-sarcopenia in Chinese elderly[J]. Sci Rep, 2016, 6: 38937.
[8] HASHIMOTO Y, TAKAHASHI F, OKAMURA T, et al. Diet, exercise, and pharmacotherapy for sarcopenia in people with diabetes[J]. Metabolism, 2023, 144: 155585.
[9] CRUZ-JENTOFT A J, SAYER A A. Sarcopenia[J]. Lancet, 2019, 393(10191): 2636-2646.
[10] CHO M R, LEE S, SONG S K. A review of sarcopenia pathophysiology, diagnosis, treatment and future direction[J]. J Korean Med Sci, 2022, 37(18): e146.
[11] CUI M, GANG X, WANG G, et al. A cross-sectional study: associations between sarcopenia and clinical characteristics of patients with type 2 diabetes[J]. Medicine, 2020, 99(2): e18708.
[12] NISHIMOTO K, DOI T, TSUTSUMIMOTO K, et al. Relationship between diabetes status and sarcopenia in community-dwelling older adults[J]. J Am Med Dir Assoc, 2022, 23(10): 1718. e7-1711718. e12.
[13] KHATEEB J, FUCHS E, KHAMAISI M. Diabetes and lung disease: a neglected relationship[J]. Rev Diabet Stud, 2019, 15: 1-15.
[14] VAN DEN BORST B, GOSKER H R, ZEEGERS M P, et al. Pulmonary function in diabetes: a meta analysis[J]. Chest, 2010, 138(2): 393-406.
[15] ZHANG R H, ZHOU J B, CAI Y H, et al. Non-linear association between diabetes mellitus and pulmonary function: a population-based study[J]. Respir Res, 2020, 21(1): 292.
[16] CRUZ-JENTOFT A J, BAHAT G, BAUER J, et al. Sarcopenia: revised European consensus on definition and diagnosis[J]. Age Ageing, 2019, 48(4): 601.
[17] ROZENBERG D, MADDOCKS M. Looking beyond BMI classifications with complementary assessment of body composition in COPD[J]. Chest, 2023, 163(5): 1003-1004.
[18] CHEN C, HUANG Z, LIU L, et al. Lung function impairment and risks of incident cardiovascular diseases and mortality among people with type 2 diabetes: a prospective cohort study[J]. Diabetes Care, 2025, 48(5): 728-736.
[19] FUSO L, PITOCCO D, CONDOLUCI C, et al. Decline of the lung function and quality of glycemic control in type 2 diabetes mellitus[J]. Eur J Intern Med, 2015, 26(4): 273-278.
[20] KINNEY G L, BLACK-SHINN J L, WAN E S, et al. Pulmonary function reduction in diabetes with and without chronic obstructive pulmonary disease[J]. Diabetes Care, 2014, 37(2): 389-395.

Relationship of sarcopenia with lung function in elderly patients with type 2 diabetes mellitus

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Metrics

Recommended 10

[1]	YI Xinmei, ZHANG Fei, WANG Jiahe. Research progress on the association between inflammation and sarcopenia in the elderly [J]. Practical Geriatrics, 2025, 39(7): 654-658.
[2]	KANG Shengqin, WANG Xuefei, DENG Shunzhi, OUYANG Xiaaojun, WU Haidi, SHEN Xiaoxing, LIU Xiaoqin, MO Yongzhen. Correlation between stress urinary incontinence and sarcopenia in elderly women [J]. Practical Geriatrics, 2025, 39(7): 703-707.
[3]	WANG Qi, WANG Zhe, WANG Yuehui. Research progress on inflammation and sleep disorders [J]. Practical Geriatrics, 2025, 39(6): 543-546.
[4]	GAO Di, CHEN Renchang, LIANG Songlin, WANG Chenmoji, LI Nianhu. Research progress of Hippo pathway in regulating the differentiation of mesenchymal stem cells based on osteo-sarcopenia [J]. Practical Geriatrics, 2025, 39(6): 626-630.
[5]	CHEN Lijuan, DONG Dan, LIU Yilin, ZHANG Yi, YU Hehua. Analysis of risk factors for in-hospital death in elderly patients with type 2 diabetes mellitus complicated with severe pneumonia [J]. Practical Geriatrics, 2025, 39(5): 514-518.
[6]	LU Kun, ZHANG Yan, PENG Xianghong, HONG Lei, YE Qing, DONG Guangqiang. Association between sleep duration and glycemic control among community elderly patients with type 2 diabetes mellitus [J]. Practical Geriatrics, 2025, 39(4): 406-410.
[7]	HAO Shijie, LIU Xihua, WEI Chen, ZOU Jianpeng. Correlation between respiratory dysfunction and articulation function in elderly patients with stroke [J]. Practical Geriatrics, 2025, 39(2): 139-143.
[8]	RONG Can, MU Dinghuang, HU Yun. Correlation between serum dehydroepiandrosterone sulfate-to-age ratio and diabetic kidney disease in elderly male patients with type 2 diabetes mellitus [J]. Practical Geriatrics, 2025, 39(2): 179-182.
[9]	FEI Qinnan, CHEN Xinglan, OUYANG Xiaojun, GU Liubao. A review of association between type 2 diabetes mellitus and malignant tumors in elderly patients [J]. Practical Geriatrics, 2025, 39(2): 212-216.
[10]	DONG Xiaofei, ZHANG Fei, WANG Jiahe. Relationship between environmental exposure and sarcopenia [J]. Practical Geriatrics, 2025, 39(1): 8-11.
[11]	SONG Chengya, YANG Ying, HONG Kan. Effect and mechanism of short-chain fatty acids on sarcopenia in elderly patients complicated with type 2 diabetes mellitus [J]. Practical Geriatrics, 2025, 39(1): 98-101.
[12]	LI Jiang, QIU Yan, WANG Ting, WANG Dan, YU Yifan, PU Lingli, BU Ling. Correlation between preoperative SII/ALB and clinicopathologic features in elderly patients with lung adenocarcinoma [J]. Practical Geriatrics, 2024, 38(9): 893-896.
[13]	QI Jiaying, YIN Tongtong, WANG Fangfang, ZHANG Hui, WANG Li. A dose-response Meta-analysis of the association between physical activity and the risk of sarcopenia in the elderly [J]. Practical Geriatrics, 2024, 38(9): 905-910.
[14]	GAO Yuan, CHEN Hua, CHEN Ke, HUANG Wenlong. Relationship of bone mineral density and fracture risk with type 2 diabetes mellitus-related factors in elderly patients [J]. Practical Geriatrics, 2024, 38(9): 911-915.
[15]	DAI Jing, CUI Yan. Correlation between glycosylated hemoglobin variability and cognitive dysfunction in elderly patients with type 2 diabetes mellitus [J]. Practical Geriatrics, 2024, 38(9): 931-935.