基于肌少-骨质疏松症的Hippo通路调控间充质干细胞分化的研究进展

doi:10.3969/j.issn.1003-9198.2025.06.019

Abstract

Abstract: Hippo signaling pathway plays an important role in the regulation of cell and tissue growth. Hippo signaling pathway regulates certain cell lineage-specific transcription factors through its downstream transcriptional effectors of Yes-associated protein (YAP) and WW domain-containing transcriptional regulator (TAZ). Thus, it affects the differentiation of mesenchymal stem cells (MSCs) into osteogenic, adipogenic and myogenic directions. The basic pathology of osteo-sarcopenia (OS) is lipotoxicity mediated by fatty infiltration of muscle and bone, which in turn leads to decreased muscle strength and increased risk of fracture. It can be seen that the occurrence of OS is closely related to bone, skeletal muscle and fat. This article analyzes and reviews the pathways of different effectors in Hippo signaling pathway for the differentiation of MSCs into osteogenic, adipogenic and myogenic directions, in order to understand the function of Hippo signaling pathway and provide theoretical reference for the clinical treatment of OS.

Key words: Hippo signaling pathway, mesenchymal stem cells, osteo-sarcopenia

CLC Number:

R681
R685

GAO Di, CHEN Renchang, LIANG Songlin, WANG Chenmoji, LI Nianhu. Research progress of Hippo pathway in regulating the differentiation of mesenchymal stem cells based on osteo-sarcopenia[J]. Practical Geriatrics, 2025, 39(6): 626-630.

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Research progress of Hippo pathway in regulating the differentiation of mesenchymal stem cells based on osteo-sarcopenia

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