Table of Content

20 July 2025, Volume 39 Issue 7 Previous Issue   

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Association of inflammation and frailty DUAN Jingyi, MA Yanan, Aeryoubu, FENG Shuqi, YUAN Hui, LIAO Xichu, GAO Haiying 2025, 39 (7):  649-653.  doi: 10.3969/j.issn.1003-9198.2025.07.001 Abstract ( 17 )   PDF (1169KB) ( 16 )   Save The chronic inflammatory response is recognized as one of the central mechanisms accelerating aging and promoting frailty, establishing a vicious cycle of inflammation-frailty through multisystem interactions. Driven by non-infectious triggers such as cellular senescence and mitochondrial dysfunction, chronic inflammation suppresses anabolic growth factor expression while activating catabolic pathways, thereby accelerating sarcopenia development and promoting frailty progression. Conversely, frailty not only serves as a consequence of chronic inflammation but also may reciprocally exacerbate systemic inflammation through mechanisms including immune dysregulation, metabolic disturbances, mitochondrial dysfunction, and gut microbiota dysbiosis. This review synthesizes current evidence on the bidirectional relationship between frailty and inflammation, elucidates underlying pathophysiological mechanisms, and proposes targeted intervention strategies along with future research priorities in this emerging field. References | Related Articles | Metrics

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Research progress on the association between inflammation and sarcopenia in the elderly YI Xinmei, ZHANG Fei, WANG Jiahe 2025, 39 (7):  654-658.  doi: 10.3969/j.issn.1003-9198.2025.07.002 Abstract ( 21 )   PDF (1187KB) ( 15 )   Save Sarcopenia is a geriatric syndrome characterized by the decline in muscle mass, strength, and function associated with aging. It severely affects the quality of life of the elderly and increases the risk of various adverse health outcomes. Changes in hormone levels, mitochondrial dysfunction, degeneration of neuromuscular junctions, insufficient nutritional intake, lack of physical activity, chronic diseases, etc. are all related to the occurrence of sarcopenia. Among them, inflammation plays a crucial role in the occurrence and development of sarcopenia. This article reviews the research progress on the relationship between inflammation and sarcopenia, aiming to deeply understand the interaction between inflammation and sarcopenia, and provide a reference for the development of effective prevention and treatment measures. References | Related Articles | Metrics

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Research progress on the relationship between inflammation and chronic pain ZHOU Chong, LIU Zuwang, ZHANG Fei, WANG Jiahe 2025, 39 (7):  659-662.  doi: 10.3969/j.issn.1003-9198.2025.07.003 Abstract ( 14 )   PDF (1061KB) ( 13 )   Save Inflammation and chronic pain are two common factors leading to a decline in the quality of life and functional impairments in the elderly, with a close relationship between them. This article reviews the relationship, mechanisms, and treatments of inflammation and chronic pain, aiming to provide a theoretical basis for a deeper understanding of the role of inflammation in the development of chronic pain, and to offer guidance for clinical practice. References | Related Articles | Metrics

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Mechanism of chitosan-collagen-salvianolic acid slow-release composite membrane inhibiting inflammation in epidural scar tissue after lumbar laminectomy in rabbits WAN Xuan, KUANG Jun, GONG Jianbin, LIANG Chaoyi, WU Fan, SHU Zhimin, LIANG Weidong, WAN Xiaoming, YU Zhaozhong 2025, 39 (7):  663-668.  doi: 10.3969/j.issn.1003-9198.2025.07.004 Abstract ( 14 )   PDF (3064KB) ( 14 )   Save Objective To investigate the mechanism of chitosan-collagen-salvianolic acid slow-release composite membrane inhibiting inflammation in epidural scar tissue following lumbar laminectomy in rabbits. Methods A lumbar laminectomy model was established in rabbits using a surgical procedure. Different materials including normal saline(Model group), sodium hyaluronate (SH, M+SH group), chitosan-collagen composite membrane (CC, M+CC group), and chitosan-collagen-salvianolic acid slow-release composite membrane (CCS, M+ CCS group)were applied to the surgical area of the rabbit lumbar laminectomy model. The animals were sacrificed 4 or 8 weeks after operation. The apoptosis of lumbar vertebrae bone tissue was detected using TUNEL staining, and the expression levels of interleukin(IL)-1β, IL-6 mRNA and tumor necrosis factor (TNF)-α,transforming growth factor(TGF)-β1 protein at epidural scar tissue were analyzed using real-time quantitative reverse transcription polymerase chain reaction(qRT-PCR) and Western blot (WB), respectively. Results Compared to Sham group,the number of apoptotic cells, the expression levels of IL-6 and IL-1β mRNA and TNF-α protein were significantly increased, and the expression level of TGF-β1 protein was significantly decreased in Model group 4 and 8 weeks after operation. Compared with Model group, the number of apoptotic cells,the expression levels of IL-6 and IL-1β mRNA and TNF-α protein were significantly decreased, and the expression level of TGF-β1 protein was significantly increased in M+CCS group (P<0.05) 4 and 8 weeks after operation. Conclusions The chitosan-collagen-salvianolic acid slow-release composite membrane can inhibit the inflammation at epidural scar tissue after lumbar laminectomy in rabbits by inhibiting the expression of pro-inflammatory factors (IL-1β、TNF-α and IL-6) and upregulating TGF-1β protein activity, thereby significantly reducing scar tissue cell apoptosis. References | Related Articles | Metrics

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Effects of early time-restricted feeding on metabolic status and senescence-associated secretory phenotype in patients with metabolic syndrome CHEN Mengqi, FAN Haoling, ZHANG Yuanyuan, WU Tingyu, ZHANG Dongmei, CHENG Kai 2025, 39 (7):  669-673.  doi: 10.3969/j.issn.1003-9198.2025.07.005 Abstract ( 15 )   PDF (1109KB) ( 14 )   Save Objective To investigate the effects of early time-restricted feeding (eTRF) on metabolic status and senescence-associated secretory phenotype (SASP) in the patients with metabolic syndrome. Methods Using a randomized block grouping method, 60 patients with metabolic syndrome who were admitted to the Fourth Affiliated Hospital of Nanjing Medical University from 2022 to 2023 were randomly divided into the control group (30 cases) and the intervention group (30 cases).The control group did not limit their eating time and calorie intake, while the intervention group received an eTRF diet. The body indexes, blood lipids, blood glucose, and SASP levels were compared between the groups before and after 6 weeks of intervention. Results Two patients dropped out of the study during the 6-week intervention period.According to the age, each group was further divided into non-elderly subgroup (aged<60 years old) and elderly subgroup (aged≥60 years old). There were 15 cases in each subgroup of the control group, and 14 cases in each subgroup of the eTRF group.Compared to those before intervention, there were no statistically significant differences in the levels of body mass, body mass index,waist circumference, triglyceride, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol (HDL-C), and fasting blood glucose among the four subgroups after 6 weeks of intervention (P>0.05). However, the magnitudes of change (differences) between the subgroups for these indicators showed statistically differences, except for waist circumference, triglyceride and HDL-C. The levels of interleukin(IL)-6, IL-1β, tumor necrosis factor(TNF)-α and interferon(IFN)-γ in the two subgroups of the eTRF group were significantly reduced after 6 weeks of intervention (P<0.05), while those indicators did not changed significantly in the two subgroups of the control group after 6 weeks of intervention (P>0.05). Conclusions eTRF model can reduce the levels of SASP in the patients with metabolic syndrome. References | Related Articles | Metrics

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Efficacy of faricimab in the treatment of refractory neovascular age-related macular degeneration FANG Yiming, SHI Wei, ZHOU Xin, ZHAO Chunlin, ZHANG Siya, WANG Jing, SUN Huaping, PEI Yu, CHEN Xi, PAN Li, JIN Qingzi, TAO Kang, LIN Lin 2025, 39 (7):  674-680.  doi: 10.3969/j.issn.1003-9198.2025.07.006 Abstract ( 14 )   PDF (7615KB) ( 16 )   Save Objective To evaluate the efficacy of intravitreal injection of faricimab in the patients with refractory neovascular age-related macular degeneration (nAMD). Methods A total of twenty patients with refractory nAMD who had poor responses to previous multiple antivascular endothelial growth factor(VEGF)treatments were enrolled. They received a single intravitreal injection of faricimab in the Ophthalmologic Department of Affiliated Hospital of Nanjing University of Chinese Medicine from April 27 to May 31, 2024. Best corrected vision acuity (BCVA), macular retinal thickness (MRT) which meant the inner limiting membrane to Bruch membrane, central retinal thickness (CST),central choroid thickness (CCT), outer retinal thickness (the outer plexiform layer to Bruch membrane), maximal pigment epithelial detachment (PED) height and area, and neovascularization area (NA) were evaluated before treatment(T1) and 1 week(T2), 1 month(T3), 2 months(T4), and 3 months(T5) after treatment. Results The study included 20 patients (20 eyes). Compared with those before treatment, BCVA and NA were significantly improved 1 week after treatment. BCVA, PED height and NA were significantly improved 1 month after treatment. BCVA, CST, MRT, PED height and NA were significantly improved 2 months after treatment. BCVA, CST, PED height and PED area were significantly improved 3 months after treatment. Additionally, 1 week and 1 month after treatment, CCT showed a positive correlation with PED height and PED area. Conclusions Intravitreal injection of faricimab can effectively improve BCVA, reduce CST and PED height, and decrease PED area in the patients with refractory nAMD. References | Related Articles | Metrics

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Clinical significance of serum level of cysteine-rich angiogenic inducer 61 in elderly patients with chronic heart failure ZUO Guangfeng, XIE Hao, YAN Yufeng, ZHENG Yaguo, LIN Song 2025, 39 (7):  681-685.  doi: 10.3969/j.issn.1003-9198.2025.07.007 Abstract ( 19 )   PDF (1230KB) ( 15 )   Save Objective To explore the relationship between the serum level of cysteine-rich angiogenic inducer 61 (CCN1) and the severity of chronic heart failure (CHF) in the elderly patients. Methods A total of 136 elderly patients with CHF were enrolled as case group and divided into Ⅱ, Ⅲ, Ⅳ subgroups according to the cardiac function class of New York Heart Association (NYHA). During the same period, 29 healthy elderly individuals were selected as control group. Serum levels of CCN1 and N-terminal pro-brain natriuretic peptide(NT-proBNP)of the two groups were detected by enzyme-linked immunosorbent assay (ELISA). Pearson correlation analysis was performed to evaluate the associations of CCN1 with NT-proBNP and left ventricular ejection fraction (LVEF). Multivariate logistic regression analysis was used to identify independent factors associated with NYHA grade Ⅲ-Ⅳ. The predictive value of serum CCN1 for NYHA grade Ⅲ-Ⅳ was evaluated by receiver operating characteristic (ROC) curve. Results Serum level of CCN1 was significantly increased in case group compared to control group(P<0.01), and was increased progressively with worsening CHF severity. Pearson analysis indicated that the level of serum CCN1 was positively correlated with NT-proBNP(r=0.662, P <0.001), whereas negatively correlated with LVEF(r=－0.493, P<0.001). Multivariate logistic regression analysis showed that CCN1 was independently associated with NYHA cardiac function class Ⅲ-Ⅳ after adjusting for other clinical variables (OR=1.124, 95%CI: 1.034－1.254, P=0.012). The ROC curve showed that serum CCN1 level had a good predictive value for NYHA grade Ⅲ-Ⅳ (AUC=0.959, 95%CI:0.917－0.984,P<0.001), with an ideal cutoff value of 2.826 pg/mL, sensitivity of 91.3%, specificity of 90.3% and Youden index of 0.816. Conclusions The serum level of CCN1 may act as a potential indicator to evaluate the severity of CHF in the elderly. References | Related Articles | Metrics

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Association between proteomics-based biological age and the incidence, mortality and prognosis of cancers WANG Guanrong, BAO Yunying, ZHANG Lulu, LU Shengnan, SHEN Sipeng 2025, 39 (7):  686-692.  doi: 10.3969/j.issn.1003-9198.2025.07.008 Abstract ( 13 )   PDF (5437KB) ( 16 )   Save Objective To explore the association between proteomics-based biological age and the incidence, mortality due to tumors and prognostic outcomes of cancers. Methods A total of 52 680 participants from the proteomics cohort of the UK Biobank were enrolled in this study. Eighteen types of cancers with more than 100 new cases were analyzed. The biological age was calculated using ProtAge-204 based on proteomics and machine learning. The association between chronological age and biological age was evaluated using linear correlation. The associations between biological age and the incidence, mortality due to tumors, and prognosis of all tumors and each individual tumor were analyzed using the Cox proportional hazards model. Results The ProtAge-204 biological age was highly associated with chronological age in the validation set (R2=0.84), which could be used as a biomarker of biological age. Biological age was significantly associated with the risk of overall cancer incidence (HRper year=1.03, 95%CI: 1.02－1.04), the risk of overall cancer mortality (HRper year=1.09, 95%CI: 1.07－1.11), and prognostic outcomes (HRper year=1.05, 95%CI: 1.02－1.17). Moreover, in terms of mortality risk (HRchronage=1.02)and prognostic outcomes(HRchronage=0.99), biological age performed better than the traditional chronological age. Subsequently, in the analysis of each cancer type, biological age was significantly associated with the incidence risk of 8 types of cancers and the tumor-related mortality of 7 types of cancers, which was better than chronological age (6 types for incidence and 2 types for mortality). In terms of prognostic outcomes, neither age type showed a widespread association trend. Conclusions In this study, biological age constructed by proteomic biomarkers is significantly associated with cancer incidence, tumor-related mortality, and prognostic outcomes. Compared with chronological age, it has certain advantages and is recommended as a biomarker of aging. References | Related Articles | Metrics

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Relationship of sarcopenia with lung function in elderly patients with type 2 diabetes mellitus ZHANG Shaohong, ZHANG Ling, WANG Mengxi, SUN Mengyue, LU Peng,ZHAO Songqing, WANG Weimin 2025, 39 (7):  693-697.  doi: 10.3969/j.issn.1003-9198.2025.07.009 Abstract ( 14 )   PDF (1100KB) ( 14 )   Save Objective To investigate the correlation between sarcopenia and lung function in the elderly patients with type 2 diabetes mellitus (T2DM). Methods A total of 250 elderly T2DM patients treated in the Geriatric Department of Huai’an First People’s Hospital from January 2023 to September 2024 were enrolled in this study. Based on the presence of sarcopenia, the subjects were divided into sarcopenia group(75 cases) and non-sarcopenia group (175 cases). The differences in general data, related indexes of muscle measurements and lung function were compared between the two groups. Correlation analysis was performed to investigate the factors associated with lung function in the elderly T2DM patients. Results The levels of walking speed and grip strength, body mass index (BMI), hemoglobin, lymphocyte count, forced expiratory volume in 1 second (FEV1), and FEV1/ forced vital capacity (FVC) in sarcopenia group were significantly lower than those in non-sarcopenia group (P<0.05). The duration of T2DM, and the levels of fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c) and alanine aminotransferase (ALT) were significantly higher than those in non-sarcopenia group (P<0.05). In sarcopenia group, FEV1 and FEV1/FVC showed significant negative correlations with age and T2DM duration (P<0.05), while showing positive correlations with BMI, grip strength, gait speed, and muscle mass (0.5<r<0.8, P<0.05). In non-sarcopenia group, FEV1 and FEV1/FVC were weakly correlated with grip strength, gait speed, and muscle mass (0.3<r<0.5, P<0.05). Multivariate linear regression analysis showed that age, duration of T2DM, and sarcopenia were independent factors associated with FEV1 and FEV1/FVC in the elderly T2DM patients. Conclusions The risk of lung function decline in the elderly T2DM patients with sarcopenia is higher than that in non-sarcopenia patients. Early screening and effective intervention for sarcopenia are crucial for preventing and managing pulmonary dysfunction complications in the elderly T2DM patients. References | Related Articles | Metrics

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Analysis of risk factors for over-anticoagulation with warfarin in elderly patients with valvular atrial fibrillation SUN Lusheng, ZHANG Lifang, GAO Junjie, TANG Xiuying 2025, 39 (7):  698-702.  doi: 10.3969/j.issn.1003-9198.2025.07.010 Abstract ( 12 )   PDF (1107KB) ( 16 )   Save Objective To analyze the risk factors of over-anticoagulation with warfarin in the elderly patients with valvular atrial fibrillation. Methods A total of 235 elderly patients with valvular atrial fibrillation who were treated with warfarin from March 2022 to May 2024 were selected. According to the international standardized ratio (INR) after 7 days of treatment, the patients were divided into over-anticoagulation group and normal anticoagulation group. The clinical data of the two groups were compared, and the risk factors of over-anticoagulation in the elderly patients with valvular atrial fibrillation were analyzed. The predictive value of the risk factors for over-anticoagulation was analyzed. Results Among 235 patients, the incidence rate of over-anticoagulation was 22.98% (54/235). The proportion of the patients aged 80 years or older, combined with hypoproteinemia, and combined with amiodarone, the number of combined medication, the levels of creatinine and aspartate aminotransferase (AST), and initial warfarin dose at admission in the over-anticoagulation group were higher than those in the normal anticoagulation group, and the level of alanine aminotransferase (ALT), the body mass and the proportion of diabetes mellitus were lower than those in the normal anticoagulation group (P<0.05). Logistic regression analysis showed that age ≥80 years (OR=3.991, 95%CI: 1.754-9.078), the level of AST at admission (OR=4.764, 95%CI: 2.094-10.836), the number of combination medication (OR=4.170, 95%CI: 1.833-9.487) were independent risk factors, and body mass (OR=0.277, 95%CI: 0.122-0.630) was the protective factor for over-anticoagulation in the elderly patients with valvular atrial fibrillation. The area under the receiver operating characteristic curve of age ≥80 years, AST at admission, the number of combined medication, body mass and combined model in predicting over-anticoagulation was 0.656, 0.885, 0.792, 0.691 and 0.978, respectively (P<0.05). Conclusions The elderly patients with valvular atrial fibrillation who have older age, higher AST level at admission, higher number of combined medication, and lower body mass have a higher risk of over-anticoagulation with warfarin. The development of targeted management strategies can help to reduce the risk of over-anticoagulation in the elderly patients with valvular atrial fibrillation. References | Related Articles | Metrics

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Correlation between stress urinary incontinence and sarcopenia in elderly women KANG Shengqin, WANG Xuefei, DENG Shunzhi, OUYANG Xiaaojun, WU Haidi, SHEN Xiaoxing, LIU Xiaoqin, MO Yongzhen 2025, 39 (7):  703-707.  doi: 10.3969/j.issn.1003-9198.2025.07.011 Abstract ( 14 )   PDF (1105KB) ( 14 )   Save Objective To investigate the relationship between stress urinary incontinence (SUI) and sarcopenia in the elderly women. Methods A total of 268 elderly women at the Affiliated Geriatric Hospital of Nanjing Medical University from September 2023 to August 2024 were collected, including 176 patients presenting with SUI (SUI group) and 92 without urinary incontinence (non-urinary incontinerce group). The sarcopenia-related parameters, sociodemographic characteristics, comprehensive geriatric assessment data, and laboratory biomarkers were recorded and compared between the two groups. Propensity score matching (PSM) was employed to control the potential confounding factors, and binary logistic regression analysis was performed to identify the influencing factors for SUI in the elderly women. Results After PSM, the difference in the prevalence of sarcopenia between the two groups was statistically significant (P<0.05). Binary logistic regression analysis indicated that sarcopenia was an independent risk factor for SUI in the elderly women. Conclusions SUI is closely associated with sarcopenia in the elderly women. Screening sarcopenia is important to reduce the risk of SUI and improve the quality of life in the elderly women. References | Related Articles | Metrics

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Establishment of a predictive model of depression risk for elderly people living alone in China CHEN Shihao, JU Keke, CAO Weina, WANG Bin 2025, 39 (7):  708-713.  doi: 10.3969/j.issn.1003-9198.2025.07.012 Abstract ( 13 )   PDF (1546KB) ( 14 )   Save Objective To establish a predictive model of depression risk for elderly people living alone, and to provide scientific basis for early prevention and control of depression. Methods Empirical analysis was conducted using the fifth round of China Health and Retirement Longitudinal Study (CHARLS) survey project, and the data set was randomly divided into a prediction set and a validation set with a 7∶3 ratio. Multivariate logistic regression was used to construct a predicting model of depression risk for elderly people living alone. The receiver operating characteristic(ROC) curve and the area under the curve(AUC) was used to determine the model’s discrimination, and the Hosmer-Lemeshow goodness of fit test, calibration curve graph, clinical decision curve, and clinical impact curve were used to evaluate the accuracy and clinical benefits of the model. Results The results of multiple logistic regression analysis showed that self-rated health, life satisfaction, pain and discomfort, and physical activity were the main influencing factors for depression in elderly people living alone (P<0.05). The AUC of the training set and validation set risk models in predicting depression were 0.754 (95% CI: 0.716-0.792) and 0.813 (95% CI: 0.763-0.861), respectively. The P-value of the Hosmer-Lemeshow test for the training set was 0.591, and for the validation set was 0.779(P>0.05) with good goodness of fit. The clinical decision curve and clinical impact curve suggested that the prediction model had good clinical net benefits. Conclusions Decreased self-rated health, decreased life satisfaction, physical pain and discomfort, and inability to engage in physical activity can increase the risk of depression in elderly people living alone, which provides a basis for early screening of depression in elderly people living alone. References | Related Articles | Metrics

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Study on the function of relevant brain area in elderly patients with cerebral infarction treated with electro acupuncture at scalp-acupoint ZHANG Beiwei, HU Qiuju, HUANG Danqing, WANG Ming, ZHU Boyi, GE Wei 2025, 39 (7):  714-718.  doi: 10.3969/j.issn.1003-9198.2025.07.013 Abstract ( 10 )   PDF (4104KB) ( 12 )   Save Objective To study the effects of electroacupuncture at scalp points on functional changes of the cerebral regions in the elderly patients with cerebral infarction (CI) by functional magnetic resonance imaging (fMRI) method, and to reveal the regulatory effect of scalp acupuncture on central nervous system. Methods Thirty elderly patients with CI were treated with electroacupuncture stimulation at scalp points. The anterior parietal oblique line and posterior parietal oblique line at the head points on the side of the lesion were selected. The patients were scanned with rs-fMRI before and after acupuncture. The changes in regional homogeneity (ReHo) and fractional amplitude of low frequency oscillation (fALFF) of brain functional areas before and after acupuncture were compared. Results After electroacupuncture intervention, the ReHo values were significantly increased at the brain areas such as superior temporal gyrus (STG), middle temporal gyrus (MTG), supramarginal gyrus (SMG) and superior parietal lobule (SPL), indicating that neural activity in these areas is synchronized, which might reflect the regulatory effect of electroacupuncture treatment on brain functional networks. In addition, the fALFF values at STG and MTG also increased significantly, suggesting that the intensity of spontaneous neural activity in these brain areas increased. Conclusions Electroacupuncture at scalp points can quickly activate neural activity in damaged brain functional areas in the elderly patients with CI, and promote the recovery of damaged brain functional areas by improving circulation in relevant brain functional areas. References | Related Articles | Metrics

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Clinical characteristics of orthostatic hypotension in elderly patients with hypertension GE Weiying, LIANG Yinghui, CHEN Yiwen, GUO Ying, JI Tong, CUI Yao, WANG Guohong, LIU Qian 2025, 39 (7):  719-722.  doi: 10.3969/j.issn.1003-9198.2025.07.014 Abstract ( 13 )   PDF (1075KB) ( 16 )   Save Objective To explore the clinical characteristics of orthostatic hypotension(OH) in the elderly patients with hypertension, so as to provide evidence for the patient management. Methods A total of 115 cases of hypertension admitted to Department of Geriatrics,Beijing Tongren hospital were enrolled from September 2023 to May 2024. The supine blood pressure and orthostatic blood pressure of the patients were measured to diagnose OH, and the orthostatic intolerance symptoms were recorded. The general information, comorbidities, medication history and nutrition indicators of the patients were collected and compared. Results The overall prevalence of OH was 31.3% (36/115), and the prevalence of outpatients was 20.0% (8/40), and the prevalence of inpatients was 37.3% (28/75). The proportion of the patients with hypertension combined with orthostatic intolerance symptoms was 13.9%. Compared with the patients without OH, the proportion of cerebrovascular disease,peripheral artery disease, and antidepressant use was higher, and the serum albumin level was lower in the patients with hypertension combined with OH (P<0.05). Conclusions Cerebrovascular disease, peripheral arterial disease, antidepressants use and low level of albumin may be associated with OH in the elderly patients with hypertension. References | Related Articles | Metrics

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Analysis of prevalence and influencing factors of oral frailty in elderly patients with diabetes YI Hua, WU Jin, CHEN Xiaoyan, HONG Kexia, CHEN Zhipeng 2025, 39 (7):  723-726.  doi: 10.3969/j.issn.1003-9198.2025.07.015 Abstract ( 13 )   PDF (1076KB) ( 14 )   Save Objective To investigate the prevalence and influencing factors of oral frailty in the elderly patients with diabetes. Methods A total of 232 patients with type 2 diabetes mellitus admitted to Yancheng Third People’s Hospital from October 2023 to May 2024 were enrolled in this study by convenient sampling method. The general data questionnaire, Oral Frailty Index-8(OFI-8), Elderly Oral Health-Related Self-Efficacy Scale, Generalized Anxiety Disorder Scale, Simple Version of Geriatric Depression Scale were evaluated in the patients. Results The median OFI-8 score of all the patients was 4 (2,7). There were 52 cases (22.41 %) with low risk of oral frailty, 59 cases (25.43%) with moderate risk, and 121 cases (52.16 %) with high risk. Multivariate logistic regression analysis showed that aged >75 years old, duration of diabetes >5 years and anxiety were risk factors (P<0.05), and higher education level, higher monthly income per capita and higher oral health self-efficacy were protective factors for high risk of oral frailty in the elderly patients with diabetes (P<0.05). Conclusions The incidence rate of high risk of oral frailty in elderly diabetic patients is 52.16 %. Age, course of diabetes, anxiety, education level, income and oral health self-efficacy are the main influencing factors for oral frailty. References | Related Articles | Metrics

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Study on the safety of trajectory for deep brain stimulation in elderly patients E Yuqian, CAO Wenping, ZHAO Chunsheng, CAO Shengwu 2025, 39 (7):  727-731.  doi: 10.3969/j.issn.1003-9198.2025.07.016 Abstract ( 14 )   PDF (4408KB) ( 14 )   Save Objective To study the safety of deep brain stimulation surgery (DBS) in the elderly patients with Parkinson’s disease receiving different surgical strategies by simulating the puncture of DBS through the operation planning workstation. Methods The clinical data of 254 elderly patients with Parkinson’s disease aged ≥65 years who underwent DBS in the First Affiliated Hospital of Nanjing Medical University from 2014 to 2023 were retrospectively analyzed. The images of the patients were transfered to the operation planning workstation. Each case used the traditional surgical puncture strategy (control group) and the customized puncture strategy (customized group) respectively to simulate the surgical puncture with the subthalamic nucleus (STN) and the lateral part of the globus pallidus (GPI) as the targets. The incidence of puncture needle path through the common high-risk anatomical structures in the brain was recorded and compared between the two groups. Results A total of 254 patients underwent simulated surgical puncture on both sides, with a total of 508 needle paths. With the STN nucleus as the puncture target, the proportion of the needle path passing through the high-risk anatomical structure in the customized group was much less than that in the control group (1.38% vs 28.94%, P<0.05); When the GPI nucleus was used as the target for puncture, the proportion of the needle path passing through the high-risk anatomical structure in the customized group was much less than that in the control group (0.98% vs 25.20%, P<0.05). Conclusions Using the operation planning system to formulate the individualized puncture path can greatly reduce the risk of puncture to the abnormal anatomical structure, reduce the bleeding complications at the puncture site, and improve the safety of the operation. References | Related Articles | Metrics

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Advances in the study of sarcopenic obesity and cardiovascular disease GAO Ying, LIANG Wei 2025, 39 (7):  732-736.  doi: 10.3969/j.issn.1003-9198.2025.07.017 Abstract ( 14 )   PDF (1087KB) ( 15 )   Save Cardiovascular diseases rank first among the causes of mortality in China. There are many risk factors for cardiovascular disease, and currently, the most widely recognized causative factors include advanced age, smoking, obesity, hypertension, hyperlipidemia, diabetes, poor dietary habits, and lack of physical exercise. With the aging of China’s population, the incidence of obesity combined with sarcopenia in people over 65 years old is increasing. The relationship between sarcopenic obesity and cardiovascular disease has been attracting much attention. This paper reviews the research progress on sarcopenic obesity and cardiovascular disease. References | Related Articles | Metrics

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Research advance on early identification and intervention of presbyphagia LIU Lin, HOU Ran, ZHANG Lingli, LIU Yan, YU Qinqin 2025, 39 (7):  737-741.  doi: 10.3969/j.issn.1003-9198.2025.07.018 Abstract ( 15 )   PDF (1080KB) ( 14 )   Save Presbyphagia refers to the transition stage in which the swallowing function of healthy elderly people gradually changes from healthy state to disease state in the process of natural aging. If effective management is not carried out in this sensitive period, older adults will be at risk of continued degradation of swallowing function, which can eventually evolve into dysphagia. Therefore, early identification and timely effective intervention are of vital significance to curb the degeneration of swallowing function. This paper reviews the concept, early symptoms and signs, risk factors, assessment methods and intervention measures of presbyphagia, in order to promote early and appropriate management of presbyphagia. References | Related Articles | Metrics

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Interpretation of the association standard for “the Nursing of Chronic Pruritus in Elderly Population” ZHONG Yuling, HE Xueyu, LE Ya, CHEN Mudiao 2025, 39 (7):  749-752.  doi: 10.3969/j.issn.1003-9198.2025.07.021 Abstract ( 13 )   PDF (1061KB) ( 15 )   Save Chronic pruritus is a common symptom of multiple diseases, which seriously affects the quality of life in the elderly. With its high incidence rate, complex mechanisms, and challenges in diagnosis and treatment, the elderly patients need comprehensive intervention from physical, psychological, social and other aspects. The association standard T/GDNAS 050-2024 (the Nursing of Chronic Pruritus in Elderly Population), developed based on the characteristics of older adults in China, provides nursing guidance and suggestions on chronic pruritus in the elderly. This paper interprets this standard from the aspects of its establishing process, pruritus assessment, topical medication care, wet-wrap therapy and health guidance. Additionally, this paper discusses considerations for clinical application to facilitate practitioners’ understanding and implementation of the standard, ultimately aiming to improve the quality of nursing care for elderly patients with chronic pruritus. References | Related Articles | Metrics

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Current status and prospects of the application of artificial intelligence in geriatric medicine teaching WANG Yang, LI Daiping, YANG Yanwu, HE Bofei, YUE Jirong, DONG Birong, GE Meiling 2025, 39 (7):  753-756.  doi: 10.3969/j.issn.1003-9198.2025.07.022 Abstract ( 10 )   PDF (1056KB) ( 13 )   Save With the rapid development of artificial intelligence (AI) technology, its application in geriatric medicine teaching is becoming more and more widespread, bringing revolutionary changes to medical education. This paper introduces the current status of AI application in comprehensive geriatric assessment, geriatric clinical internship teaching, and the whole management of geriatric patients’ conditions, and discusses how to reasonably integrate AI technology into the teaching process of geriatrics at different learning stages. This paper further explores the challenges encountered by AI in geriatrics education, covering the topics of data quality and privacy protection, technology and ethics, and the impact on teachers and students. Looking ahead, AI technology has a promising future in geriatric medicine teaching, especially in terms of technology trends, changes in teaching models, and policy and regulatory support. In conclusion, AI technology is expected to further improve the quality and efficiency of geriatrics teaching and provide strong support for cultivating the next generation of medical talents. References | Related Articles | Metrics