Practical Geriatrics ›› 2025, Vol. 39 ›› Issue (7): 649-653.doi: 10.3969/j.issn.1003-9198.2025.07.001

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Association of inflammation and frailty

DUAN Jingyi, MA Yanan, Aeryoubu, FENG Shuqi, YUAN Hui, LIAO Xichu, GAO Haiying   

  1. Department of General Medicine, the Second Affiliated Hospital of Dalian Medical University, Dalian 116023, China
  • Received:2025-04-12 Online:2025-07-20 Published:2025-07-22
  • Contact: GAO Haiying, Email: gaohaiying_dlmu@163.com

Abstract: The chronic inflammatory response is recognized as one of the central mechanisms accelerating aging and promoting frailty, establishing a vicious cycle of inflammation-frailty through multisystem interactions. Driven by non-infectious triggers such as cellular senescence and mitochondrial dysfunction, chronic inflammation suppresses anabolic growth factor expression while activating catabolic pathways, thereby accelerating sarcopenia development and promoting frailty progression. Conversely, frailty not only serves as a consequence of chronic inflammation but also may reciprocally exacerbate systemic inflammation through mechanisms including immune dysregulation, metabolic disturbances, mitochondrial dysfunction, and gut microbiota dysbiosis. This review synthesizes current evidence on the bidirectional relationship between frailty and inflammation, elucidates underlying pathophysiological mechanisms, and proposes targeted intervention strategies along with future research priorities in this emerging field.

Key words: inflammation, frailty, mechanism

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