炎性衰老在阿尔茨海默病疾病进程中的机制研究进展

doi:10.3969/j.issn.1003-9198.2025.02.021

Abstract

Abstract: As a low-grade chronic inflammatory state in the aging process, inflammaging is closely related to many chronic aging diseases. Age-related changes such as cellular senescence, mitochondrial dysfunction, defective autophagy and mitophagy, and intestinal microbial imbalance are involved in initiating and maintaining inflammaging, and play an important role in the occurrence and development of Alzheimer's disease (AD) through proinflammatory mechanisms. Related anti-inflammatory therapy is also considered to have great potential. This article analyzes the induction and regulation of inflammation by the above-mentioned factors in the aging process of AD, elucidates the important role of inflammaging in the process of AD, and provides new ideas for related anti-inflammation treatment.

Key words: Alzheimer's disease, inflammaging, mechanism

CLC Number:

R 749.16

MA Xiaoting, LIU Shanwen, YAO Linlin, BAO Runying, LI Yifeng, YANG Yifan, HU Hua. Mechanism of inflammaging in the progression of Alzheimer's disease[J]. Practical Geriatrics, 2025, 39(2): 202-206.

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Mechanism of inflammaging in the progression of Alzheimer's disease

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