PCNE分类系统在消化内科老年病人抗生素使用中的应用效果

doi:10.3969/j.issn.1003-9198.2025.06.007

Abstract

Abstract: Objective To explore the effects of Pharmaceutical Care Network Europe (PCNE) classification system-based pharmaceutical intervention practice for the use of antibiotics in the elderly patients at Department of Gastroenterology. Methods A total of 210 inpatients with digestive system diseases at Department of Gastroenterology from April 2022 to April 2024 were divided into the control group (receiving routine treatment,n=105) and the intervention group(receiving PCNE classification system-based pharmaceutical intervention and routine treatment,n=105) by random number table method. The baseline data, the length of hospital stay and the cure rate of infection were compared between the two groups. Logistic regression analysis was used to explore the influencing factors for cure rate. Results There were no significant differences in the age, gender, type of digestive system disease, and status of infection between the two groups. A total of 110 antibiotics-related drug related problems(DRPs) were found in the intervention group. Each DRP was intervened at both the doctors (n=110) and patients (n=34) level. The acceptance rate of DRPs intervention was 95.14% (137/144). The percentage of DRPs fully resolved was 90.91% (100/110). The length of hospital stay in the intervention group was slightly longer than that in the control group but the difference was not statistically significant [(9.8±7.1) d vs(8.6±5.3) d,P=0.166]. Moreover, the cure rate of infection in the intervention group was higher than that in the control group (94.29% vs 82.86%, P=0.016). Multiple logistic regression analysis showed that the implementation of PCNE classification-based DRPs intervention was a protective factor for the infection cure rate in the elderly patients with digestive system diseases after adjusting for potential confounding factors (OR=0.828, 95%CI:0.625-0.922, P=0.028). Conclusions PCNE classification system-based pharmaceutical intervention can solve the antibiotics-related DRPs, and enhance the cure rate of infection in the elderly patients at Department of Gastroenterology.

Key words: Pharmaceutical Care Network Europe classification system, digestive system diseases, aged, pharmaceutical intervention, antibiotics, drug-related problems

CLC Number:

R194

FAN Manli, HAN Yi. PCNE classification system-based pharmaceutical intervention practice for the use of antibiotics in elderly patients from the department of gastroenterology[J]. Practical Geriatrics, 2025, 39(6): 565-569.

References

[1] WANG Y, HUANG Y, CHASER C, et al. Global burden of digestive diseases: a systematic analysis of the global burden of diseases study, 1990 to 2019[J]. Gastroenterology, 2023, 165(3): 773-783.e15.
[2] MADHU S G, JAMES E, VENUR P. Appropriateness of antibiotic usage for gastrointestinal disorders in a tertiary care hospital[J]. Eur J Hosp Pharm, 2016, 23(5): 283-287.
[3] HUISKESV J B, CRAMER-VANDER WELLEC M, VANDEN ENDEC H M, et al. Communication about drug-related problems (DRPs) during patients’visits to Dutch physicians and pharmacies[J]. Health Commun, 2020, 35(2): 201-208.
[4] 彭苗苗, 张桂凡. 引入PCNE分类系统对消化内科药物相关问题进行探索与实践[J]. 中南药学, 2022, 20(11): 2683-2688.
[5] CHAND C, CHENJ H, KUOH K, et al. Drug-related problems (DRPs) identified from geriatric medication safety review clinics[J]. Arch Gerontol Geriatr, 2012, 54(1): 168-174.
[6] 陈静, 刘海燕, 李建中, 等. 老年住院病人慢性病共病模式分析[J]. 实用老年医学, 2018, 32(8): 766-769.
[7] EICHENBERGERP M, LAMPERTM L, KAHMANNI V, et al. Classification of drug-related problems with new prescriptions using a modified PCNE classification system[J]. Pharm World Sci, 2010, 32(3): 362-372.
[8] Pharmaceutical Care Network Europe Association Classification for drug related problems V 9.1. The PCNE Classification V 91 [EB/OL]. (2022-02-28)[2024-08-28]. https://www.pcne.org/upload/files/417_PCNE_classification_V9-1_final.pdf.
[9] 国家药品监督管理局药品审评中心. 抗菌药物临床试验技术指导原则[EB/OL]. (2015-04-03)[2024-08-28]. https://www.cde.org.cn/zdyz/domesticinfopage?zdyzIdCODE=b73cb8c787d7d0b62a11b8847419778e.
[10] 丁琦, 阮琼艳. 欧洲医药保健网分类系统在老年科药物监测的应用效果分析[J]. 中国社区医师, 2023, 39(9): 13-15.
[11] 刘长月, 越伟. 抗菌药与癫痫发作的相关性[J]. 中国实用神经疾病杂志, 2023, 26(4): 503-508.
[12] 肖贵英, 李昕, 邓阳, 等. 抗菌药物的肾毒性机制及危险因素研究进展[J]. 中国抗生素杂志, 2022, 47(8): 779-785.
[13] 唐甜甜, 张永红. 网络毒理方法用于抗生素肝毒性预测的研究[J]. 国外医药:抗生素分册, 2022, 43(2): 65-69.
[14] 许伟, 吴剑卿. 衰弱综合征与老年肺部感染[J]. 实用老年医学, 2022, 36(8): 784-787.
[15] 朱丽明. 关注消化科老年患者的精神心理问题[J]. 实用老年医学, 2016, 30(9): 714-716.
[16] 杨涛, 龚婧如, 陆怡, 等. 不同分类系统医院抗菌药物医嘱药物相关问题分析[J]. 中国药业, 2021, 30(24): 121-125.

PCNE classification system-based pharmaceutical intervention practice for the use of antibiotics in elderly patients from the department of gastroenterology

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Metrics

Recommended 10

[1]	LIU Wenxiu, ZHENG Meijie, LI Wei, CHEN Ziye, MENG Qiong, LI Xian. Effect of breathing exercise rehabilitation program combined with cognitive training on respiratory function and cognitive function in elderly patients with COPD [J]. Practical Geriatrics, 2025, 39(6): 577-581.
[2]	ZHANG Pei, SONG Peng, LIU Jun. Early efficacy of percutaneous endoscopic posterior lumbar interbody fusion in the treatment of lumbar degenerative diseases in the elderly [J]. Practical Geriatrics, 2025, 39(6): 586-590.
[3]	ZHANG Qian, LIU Mingming, MA Ning. Comparison of efficacy between T-tube drainage and primary closure of common bile duct following LC+LCBDE in the elderly patients aged ≥80 years [J]. Practical Geriatrics, 2025, 39(6): 591-594.
[4]	LU Shuang, WANG Jie, SUN Miao, LIU Yongping, ZHANG Kaili, LIAO Pengbin. Relationship of serum lncRNA NEAT1 and SIRT2 levels with the condition and prognosis of elderly patients with acute ischemic stroke [J]. Practical Geriatrics, 2025, 39(6): 595-600.
[5]	YANG Bin, YE Qing, DENG Tianrui, XU Yunting, XU Huiqing, AO Guofeng, TANG Wei, XU Fei. Analysis of health-related quality of life in elderly people with diabetes during and after COVID-19 pandemic in Nanjing [J]. Practical Geriatrics, 2025, 39(6): 606-610.
[6]	ZHANG Youjia, XIE Hai, RAN Feng. Characteristics of gut and plaque microbiota in the elderly with lower limb arteriosclerosis obliterans [J]. Practical Geriatrics, 2025, 39(6): 611-616.
[7]	ZHU Xiangyu, HANG Lejia, WANG Yu, WU Yuyi, ZHAO Yijing, ZHU Bei, HUANG Jingjing. Advances in artificial intelligence for cardiovascular disease in the elderly [J]. Practical Geriatrics, 2025, 39(6): 621-625.
[8]	YANG Guang, CHEN Yuhong, FENG Ping, LI Xihan, LI Ge. Application of a clinical decision support system based on early warning scores in preoperative nursing care for elderly patients with acute aortic dissection [J]. Practical Geriatrics, 2025, 39(6): 636-640.
[9]	GAN Yujing, HUANG Min. Management of complications of nutrition therapy for elderly critically ill patients [J]. Practical Geriatrics, 2025, 39(5): 433-438.
[10]	ZHOU Jing. Timing and route selection of nutritional treatment for elderly patients with critical illness [J]. Practical Geriatrics, 2025, 39(5): 439-443.
[11]	JIANG Jie, ZHOU Dandan, ZHU Baohua. Advances in energy and protein treatment goals for elderly critically ill patients [J]. Practical Geriatrics, 2025, 39(5): 444-449.
[12]	DUAN Jianfeng, YU Wenkui. Gut microbiota and critical illness in the elderly [J]. Practical Geriatrics, 2025, 39(5): 450-455.
[13]	ZHANG Jie, WANG Qifeng, MI Weinuo, ZHANG Lina, GHEN Guofang, SUN Yu, XU Shuhang, LIU Chao. The level of vitamin D and the prevalence of autoimmune thyroiditis in rural elderly: a cross-sectional study [J]. Practical Geriatrics, 2025, 39(5): 456-460.
[14]	ZHANG Yang, YANG Shun, ZANG Liuxue, LU Ziru, YU Zhenfeng, LIU Meiyu. Effects of ropivacaine combined with different concentrations of methylene blue for fascia iliaca block on postoperative analgesia and rehabilitation in patients undergoing hip arthroplasty [J]. Practical Geriatrics, 2025, 39(5): 466-471.
[15]	HUO Xiaopeng, LI Yang, ZHAO Yafang, LI Chaoyue, LAI Xiaoxing. Current status and influencing factors of depression in the community elderly with cognitive frailty [J]. Practical Geriatrics, 2025, 39(5): 477-481.