血清lncRNA NEAT1、SIRT2水平与老年急性缺血性脑卒中病人病情及预后的关系

doi:10.3969/j.issn.1003-9198.2025.06.013

Abstract

Abstract: Objective To investigate the relationship of serum long non-coding RNA nuclear paraspeckle assembly transcript 1 (lncRNA NEAT1) and silent information regulator factor 2 (SIRT2) with the condition and prognosis of the elderly patients with acute ischemic stroke (AIS). Methods A total of 163 elderly AIS patients (AIS group) admitted to Xi’an International Medical Center Hospital from January 2021 to September 2023 and 82 healthy elderly people (control group) undergoing physical examination during the same period were enrolled in this study. The elderly patients with AIS were divided into mild AIS group (32 cases), moderate AIS group (45 cases), moderate-severe AIS group (30 cases), and severe AIS group (56 cases), and were divided into poor prognosis group (52 cases) and good prognosis group (111 cases) according to the 6-month prognosis. Real-time fluorescence quantitative polymerase chain reaction and enzyme-linked immunosorbent assay were used to detect the serum levels of lncRNA NEAT1 and SIRT2, respectively. Spearman’s correlation was used to analyze the correlation of serum levels of lncRNA NEAT1 and SIRT2 with National Institute of Health Stroke Scale (NIHSS) scores. Multivariate logistic regression analysis was used to determine the risk factors for prognosis of the elderly patients with AIS. Results Compared with the control group, the serum levels of lncRNA NEAT1 and SIRT2 were higher in the AIS group (P＜0.01). As the disease gradually worsened, the serum levels of lncRNA NEAT1 and SIRT 2 gradually increased in the elderly AIS patients (all P＜0.05); Spearman’s correlation showed that the serum levels of lncRNA NEAT1 and SIRT2 were positively correlated with NIHSS scores in the elderly AIS patients (r＝0.775, 0.743, P＜0.01).The independent risk factors for poor prognosis in the elderly AIS patients were increased infarct volume, increased NIHSS score, elevated levels of lncRNA NEAT1 and SIRT2 (all P＜0.05). Conclusions Elevated serum lncRNA NEAT1 and SIRT2 levels are closely associated with exacerbation and poor prognosis in the elderly AIS patients.

Key words: aged, acute ischemic stroke, long non-coding RNA nuclear paraspeckle assembly transcript 1, silent information regulator factor 2-related enzyme 2, prognosis

CLC Number:

R743.3

LU Shuang, WANG Jie, SUN Miao, LIU Yongping, ZHANG Kaili, LIAO Pengbin. Relationship of serum lncRNA NEAT1 and SIRT2 levels with the condition and prognosis of elderly patients with acute ischemic stroke[J]. Practical Geriatrics, 2025, 39(6): 595-600.

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Relationship of serum lncRNA NEAT1 and SIRT2 levels with the condition and prognosis of elderly patients with acute ischemic stroke

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