Abstract: Objective To explore the effects of different bone cement perfusion rates on the early clinical efficacy and complications in the elderly patients with osteoporotic vertebral compression fractures undergoing percutaneous vertebroplasty (PVP) surgery. Methods A retrospective analysis was conducted on the clinical data of 167 elderly patients who underwent PVP surgery for osteoporotic vertebral compression fractures. The patients were divided into the high perfusion rate group (20%≤bone cement perfusion rate<30%, Group Ⅰ, n=71) and the low perfusion rate group (10%≤bone cement perfusion rate<20%, Group Ⅱ, n=96). The preoperative and postoperative visual analogue scale (VAS) scores and Oswestry disability index (ODI) scores, as well as the rates of bone cement leakage, adjacent vertebral fractures, and postoperative re-fracture rate of injured vertebra in the two groups were recorded and compared. Results The postoperative VAS and ODI scores in both groups were significantly improved, with statistically significant differences (P<0.01). However, there was no statistically significant difference in VAS and ODI scores between the two groups (P>0.05). The leakage rate of bone cement in Group Ⅰ was 42.25%, the fracture rate of adjacent vertebral bodies was 18.31%, compared with 23.95% and 7.29% in Group Ⅱ with significant difference(P<0.05), respectively. The postoperative re-fracture rate of injured vertebra in Group Ⅰ was 2.82%, compared with 4.17% in Group Ⅱ with no significant difference (P>0.05). Conclusions Different bone cement perfusion rates within 10%-30% can bring the same early clinical efficacy, while low bone cement perfusion rate can reduce the risk of bone cement leakage and adjacent vertebral fractures.

Key words: osteoporotic vertebral compression fracture, percutaneous vertebroplasty, bone cement perfusion rate, aged