骨化三醇对老年骨质疏松性脊柱骨折病人PKP术后骨折愈合的影响

doi:10.3969/j.issn.1003-9198.2024.03.007

Abstract

Abstract: Objective To study the effects of calcitriol on fracture healing and the levels of serum bone alkaline phosphatase (BALP), procollagen type Ⅰ N-terminal propeptide (PINP) and β-type Ⅰ collagen carboxyl terminal peptide (β-CTX) in the elderly patients with osteoporotic vertebral compression fractures (OVCF) receiving percutaneous kyphoplasty (PKP). Methods A total of 106 patients with OVCF who received PKP surgery in Hanyang Hospital Affiliated to Wuhan University of Science and Technology from January 2019 to December 2020 were enrolled in this study. And they were divided into control group and observation group according to the random number table method, with 53 cases in each group. The control group was treated with calcium combined with alendronate sodium tablets after PKP surgery, while the observation group was additionally given calcitriol. The course of treatment in both groups was 6 months. The clinical efficacy and the levels of Cobb angle, Oswestry disability index (ODI), bone mineral density and bone metabolism indicators were compared between the two groups. Results The effective rates in the observation group and the control group after 6 months of treatment were 90.57% and 83.02% (P>0.05), and the excellent and good rates were 73.58% and 52.83% (P<0.05). The levels of Cobb angle and ODI in the two groups after 1, 3 and 6 months of treatment were significantly lower than those before treatment (P<0.05), and the level of ODI in the observation group was significantly lower than that in the control group after 6 months of treatment (P<0.05). The bone mineral density after 3 and 6 months of treatment in both groups were significantly higher than those before treatment (P<0.05), and the bone mineral density after 6 months of treatment in the observation group was higher than that in the control group (P<0.05). The levels of BALP and PINP were significantly increased after 1, 3 and 6 months of treatment (P<0.05), while the level of β-CTX was significantly decreased (P<0.05) in the two groups, and the levels of BALP and PINP in the observation group were higher than those in the control group after 1, 3 and 6 months of treatment (P<0.05). Conclusions Calcitriol shows good effects in the treatment of patients with OVCF after PKP surgery through improving the bone metabolism and enhancing the bone mineral density, and it could promote the fracture healing.

Key words: osteoporotic vertebral compression fracture, aged, percutaneous kyphoplasty, calcitriol, bone alkaline phosphatase, procollagen type Ⅰ N-terminal propeptide, β-type Ⅰ collagen carboxyl terminal peptide

CLC Number:

R 683.2

YE Heng, ZHANG Weihua, HAN Jun, ZHANG Jianye, LI Yonghong. Effects of calcitriol on fracture healing in elderly patients with osteoporotic vertebral fractures undergoing PKP surgery[J]. Practical Geriatrics, 2024, 38(3): 240-244.

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Effects of calcitriol on fracture healing in elderly patients with osteoporotic vertebral fractures undergoing PKP surgery

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