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20 March 2024, Volume 38 Issue 3 Previous Issue    Next Issue

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Predictive value of carotid atherosclerosis plaque for ischemic stroke events in patients with nonvalvular atrial fibrillation ZHANG Lili, LI Jing, DING Linfeng, SUN Jingxian, CAI Jingbo 2024, 38 (3):  236-239.  doi: 10.3969/j.issn.1003-9198.2024.03.006 Abstract ( 119 )   PDF (1073KB) ( 662 )   Save Objective To explore the predictive value of carotid atherosclerosis plaque for ischemic stroke events in the elderly patients with nonvalvular atrial fibrillation(NVAF). Methods A total of 303 patients with NVAF were enrolled in the study,and were divided into the atrial fibrillation with stroke group (n=134) and the atrial fibrillation without stroke group (n=169) based on whether they suffered from ischemic stroke events. The predictive factors of ischemic stroke in the patients with NVAF were analyzed by single and multivariate regression analysis, and the predictive value was further evaluated by receiver operating characteristic (ROC)curve. Results Among the patients with atrial fibrillation and stroke, 75.4% presented with carotid atherosclerosis plaque, compared with 66.3% in the patients without stroke (P<0.05). Logistic regression analysis showed that carotid atherosclerosis plaque and CHA2DS2-VASc score were the independent risk factors for ischemic stroke in the patients with NVAF.ROC curve analysis showed that the predictive value of carotid atherosclerosis plaque combined with CHA2DS2-VASc score was better than that of CHA2DS2-VASc score alone. Conclusions In the elderly patients with NVAF, carotid atherosclerosis plaque is closely related to ischemic stroke events. The value of carotid atherosclerosis plaque combined with CHA2DS2-VASc score in predicting ischemic stroke events may be better than CHA2DS2-VASc score alone. References | Related Articles | Metrics

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Effects of calcitriol on fracture healing in elderly patients with osteoporotic vertebral fractures undergoing PKP surgery YE Heng, ZHANG Weihua, HAN Jun, ZHANG Jianye, LI Yonghong 2024, 38 (3):  240-244.  doi: 10.3969/j.issn.1003-9198.2024.03.007 Abstract ( 88 )   PDF (1870KB) ( 627 )   Save Objective To study the effects of calcitriol on fracture healing and the levels of serum bone alkaline phosphatase (BALP), procollagen type Ⅰ N-terminal propeptide (PINP) and β-type Ⅰ collagen carboxyl terminal peptide (β-CTX) in the elderly patients with osteoporotic vertebral compression fractures (OVCF) receiving percutaneous kyphoplasty (PKP). Methods A total of 106 patients with OVCF who received PKP surgery in Hanyang Hospital Affiliated to Wuhan University of Science and Technology from January 2019 to December 2020 were enrolled in this study. And they were divided into control group and observation group according to the random number table method, with 53 cases in each group. The control group was treated with calcium combined with alendronate sodium tablets after PKP surgery, while the observation group was additionally given calcitriol. The course of treatment in both groups was 6 months. The clinical efficacy and the levels of Cobb angle, Oswestry disability index (ODI), bone mineral density and bone metabolism indicators were compared between the two groups. Results The effective rates in the observation group and the control group after 6 months of treatment were 90.57% and 83.02% (P>0.05), and the excellent and good rates were 73.58% and 52.83% (P<0.05). The levels of Cobb angle and ODI in the two groups after 1, 3 and 6 months of treatment were significantly lower than those before treatment (P<0.05), and the level of ODI in the observation group was significantly lower than that in the control group after 6 months of treatment (P<0.05). The bone mineral density after 3 and 6 months of treatment in both groups were significantly higher than those before treatment (P<0.05), and the bone mineral density after 6 months of treatment in the observation group was higher than that in the control group (P<0.05). The levels of BALP and PINP were significantly increased after 1, 3 and 6 months of treatment (P<0.05), while the level of β-CTX was significantly decreased (P<0.05) in the two groups, and the levels of BALP and PINP in the observation group were higher than those in the control group after 1, 3 and 6 months of treatment (P<0.05). Conclusions Calcitriol shows good effects in the treatment of patients with OVCF after PKP surgery through improving the bone metabolism and enhancing the bone mineral density, and it could promote the fracture healing. References | Related Articles | Metrics

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Effect of cardiac valve calcification on prognosis of elderly patients with coronary heart disease ZHA Zhimin, LIU Huan, WANG Xiangming, LI Qiushuang, GUO Yan 2024, 38 (3):  245-250.  doi: 10.3969/j.issn.1003-9198.2024.03.008 Abstract ( 100 )   PDF (1246KB) ( 575 )   Save Objective To investigate the correlation between cardiac valve calcification(CVC) and major adverse cardiac and cerebral events(MACCE) in the elderly patients with coronary heart disease(CHD). Methods A total of 140 elderly patients with CHD were enrolled. The patients were divided into CVC group and non-CVC group according to echocardiography. The patients were followed up, and the incidence rate of MACCE and all-cause death were recorded and compared between the two groups by Kaplan-Meier method, and the influencing factors of MACCE were analyzed by Multivariate Cox proportional hazards models. Results There were significant differences in age, total cholesterol(TC), low-density lipoprotein cholesterol(LDL-C), albumin, and estimated glomerular filtration rate(eGFR) between the two groups(P<0.05 or P<0. 01). After 5 years of follow-up, the incidence rate of MACCE and all-cause mortality in the CVC group were higher than those in the non-CVC group(P<0.001, P=0.002). Cox regression analysis showed that CVC, urea nitrogen and left atrial diameter increased the risk of MACCE, but CVC did not increase the risk of all-cause death. Conclusions Old age and poor renal function are more prone to presenting with CVC in the elderly patients with CHD. CVC is an independent risk factor for MACCE, and the prognosis is worse in the patients with CVC. References | Related Articles | Metrics

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Evaluation of efficacy and safety of microwave ablation in treatment of benign thyroid nodules in elderly patients HU Cuining, TANG Wei, WU Dan, XU Ting, FAN Boqiang 2024, 38 (3):  251-254.  doi: 10.3969/j.issn.1003-9198.2024.03.009 Abstract ( 94 )   PDF (1836KB) ( 763 )   Save Objective To investigate the effect of ultrasound-guided percutaneous microwave ablation(MWA) on benign thyroid nodules with different components, and to analyze the effects on thyroid function in the elderly patients. Methods A total of 69 elderly patients (48 females, 21 males, 60-82 years old) with thyroid nodules who received ultrasound-guided MWA in Jiangsu Procince Geriatric Hospital and the First Affiliated Hospital of Nanjing Medical University from January 2015 to March 2018 were retrospectively enrolled. According to the main ablation nodules, the patients were divided into cystic nodules group, solid nodules group and mixed nodules group. All patients were followed up for 1, 3, 6 and 12 months after treatment.The changes of nodule volume reduction rate and thyroid function were detected. Results Twelve months after treatment, 7 patients (10.1%) presented with subclinical hypothyroidism, and 1 patient (1.4%) presented with subclinical hyperthyroidism. The serum level of thyroglobulin in all groups was significantly lower than that before treatment (P<0.01), and the serum levels of antithyroglobulin antibody (TgAb) and anti-thyroid peroxidase antibody(TPOAb) did not change significantly after MWA (P>0.05). At the 12th month of follow-up, the volume reduction rate in cystic nodule patients was 92.91%, compared with 72.55% in solid nodules group and 89.45%in mixed nodules group(P<0.05). Conclusions Ultrasound-guided percutaneous MWA is a safe and effective method for the treatment of benign thyroid nodules in the elderly patients. It can significantly reduce the volume of thyroid nodules and has slight influence on thyroid function. References | Related Articles | Metrics

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The status of health literacy and correlation with frailty in elderly patients with type 2 diabetes mellitus TANG Yuan, DENG Shufang, HE Yongmei, DAI Yuxuan, LUO Jing 2024, 38 (3):  255-259.  doi: 10.3969/j.issn.1003-9198.2024.03.010 Abstract ( 108 )   PDF (1084KB) ( 920 )   Save Objective To investigate the current status of health literacy and frailty in the elderly patients with type 2 diabetes mellitus (T2DM) and to explore the relationship between them. Methods A simple random sampling method was used to select 360 elderly patients with T2DM from four communities in Chenzhou City. The Health Literacy Scale for Chronic Disease and the Tilburg Frailty Indicator were applied to assess the patients' health literacy level and frailty status, respectively. Results The total score of health literacy in the elderly patients with T2DM was 91.35±7.69, and the total score of frailty was 6.13±2.85. Pearson correlation analysis showed that there was a negative correlation between health literacy and frailty in the elderly patients with T2DM (r=-0.613, P<0.01). Multiple linear regression analysis showed that the education level, monthly income per capita in the family, duration of T2DM and the frailty degree were associated with the level of health literacy. Conclusions The health literacy level of the elderly patients with T2DM needs to be further improved.It is important to develop targeted interventions to improve the health literacy of patients and their frailty. References | Related Articles | Metrics

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Analysis of the effects of anemia on death in elderly patients with community-acquired pneumonia PENG Zetong, ZHANG Yao, LIU Bin 2024, 38 (3):  260-264.  doi: 10.3969/j.issn.1003-9198.2024.03.011 Abstract ( 93 )   PDF (1095KB) ( 536 )   Save Objective To investigate the clinical characteristics of the elderly patients with community-acquired pneumonia (CAP) combined with anemia and the impact of anemia on the prognosis of CAP. Methods A total of 323 elderly inpatients with CAP from January 2022 to December 2022 were selected as the research subjects. According to the diagnostic criteria for anemia, they were divided into anemia group (n=151) and non-anemia group (n=172). The general information, laboratory indicators, clinical outcomes and disease severity were recorded and compared between the two groups. Logistic regression was used to analyze the correlation of laboratory indicators or anemia with the prognosis of the elderly patients with CAP. Results The levels of prothrombin time, thrombin time, D-dimer,urea nitrogen, neutrophil to lymphocyte ratio (NLR) and the number of severe pneumonia cases in the anemia group were higher than those in the non-anemia group(P<0.05). The levels of C-reactive protein (CRP), lymphocyte, total protein, albumin, albumin-globulin ratio, indirect bilirubin, glutamic pyruvic transaminase and creatine kinase isoenzyme in the anemia group were significantly lower than those in the non-anemia group (P<0.05). There were no significant differences between the two groups in white blood cell count and procalcitonin (P>0.05). Logistic regression analysis showed that anemia, CRP, D-dimer, NLR, urea nitrogen and creatinine were the independent risk factors of death in the elderly patients with CAP (P<0.05). Conclusions Anemia is an independent risk factor for the death of the elderly patients with CAP. More attention should be paid to the hemoglobin management in clinical practice. References | Related Articles | Metrics

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Application of lidocaine aerosol in painless gastroscopy in elderly patients LIU Xiangrong, SONG Shaobo, LIU Sheng'an, LI Hui, CHEN Guosheng 2024, 38 (3):  265-269.  doi: 10.3969/j.issn.1003-9198.2024.03.012 Abstract ( 94 )   PDF (1097KB) ( 653 )   Save Objective To observe the safety and effectiveness of lidocaine aerosol in painless gastroscopy in the elderly patients. Methods A total of 100 patients over 65 years old with American Society of Anesthesiologists classificationⅠ-Ⅲ in our endoscopy center receiving painless gastroscopy from June to December 2022 were divided into two groups (n=50) according to random number table. The patients in group A received lidocaine aerosol sprayed to the surface of throat, followed by intravenous anesthesia with remifentanil and propofol, while the patients in group B were directly intravenously anesthetized with remifentanil and propofol. The preoperative and the lowest intraoperative mean arterial pressure (MAP), heart rate (HR) and pulse oxygen saturation (SpO2) in the two groups were recorded and compared. The dosage during successful implantation of gastroscope and total amount of propofol, the Ramsay sedation score and recovery time, the incidence of intraoperative adverse reactions, including coughing, motility, respiratory depression (SpO2<90%), hypotension (<30% of the baseline value) and decreased HR (<50 beats/min) were recorded and compared between the two groups. Results Compared with group B, the dosage during successful implantation of gastroscope and total amount of propofol were significantly decreased (P<0.05). The intraoperative minimum MAP, HR and SpO2 were significantly increased (P<0.05), and the Ramsay sedation score and recovery time were significantly decreased (P<0.05). The incidence rates of adverse reactions of coughing, respiratory depression and hypotension were significantly reduced (P<0.05) in group A. Conclusions Lidocaine aerosol can significantly reduce the amount of propofol. At the same time, the adverse reactions of coughing, respiratory depression, hypotension and decreased heart rate are also significantly reduced. Besides, the patients receiving lidocaine aerosol present with a shorter wake-up time. Thus, lidocaine aerosol is a safe and effective anesthesia method suitable for painless gastroscopy in the elderly patients. References | Related Articles | Metrics

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Correlation between postoperative recovery level and sarcopenia in elderly patients with hip fractures CHU Limin, HUANG Qin, WEI Wei, WANG Huanhuan, MA Lixia 2024, 38 (3):  270-272.  doi: 10.3969/j.issn.1003-9198.2024.03.013 Abstract ( 84 )   PDF (1820KB) ( 551 )   Save Objective To identify the main factors affecting the postoperative recovery in the elderly patients with hip fractures and provide recommendations to improve the prognosis. Methods A total of 129 elderly patients with hip fractures were enrolled in this study including 72 males and 57 females. Harris score was used to evaluate the postoperative recovery, and muscle strength testing was used to diagnose sarcopenia. Logistic regression was used to assess the correlation of sarcopenia and other indicators with postoperative recovery in the elderly patients with hip fracture. Results Univariate analysis showed there were statistically significant differences in skeletal muscle mass index(SMI), skeletal muscle mass, the levels of inorganic salt and vitamin D, sarcopenia between Harris score ≥80 group and Harris score <80 group(P<0.05). Multivariate Logistic regression analysis showed that sarcopenia, vitamin D and inorganic salt content were independent risk factors of postoperative recovery in the elderly patients with hip fracture. Conclusions It is important to intervene sarcopenia and related factors in the elderly patients with hip fracture postoperatively to shorten the recovery time and improve the overall recovery outcomes. References | Related Articles | Metrics

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Comparison of clinical efficacy of percutaneous endoscopic transforaminal lumbar interbody fusion and minimally invasive transforaminal lumbar interbody fusion in the treatment of lumbar degenerative diseases LI Yongqi, LUO Rui, WANG Shaobo, JIN Yong, WANG Jian, WU Hongzi, WANG Shun, YUAN Feng, ZHAO Jianxin, BAI Zongbiao, LIAO Yi 2024, 38 (3):  273-277.  doi: 10.3969/j.issn.1003-9198.2024.03.014 Abstract ( 87 )   PDF (1096KB) ( 456 )   Save Objective To compare the clinical efficacy, safety of percutaneous endoscopic transforaminal lumbar interbody fusion (Endo-LIF) and minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) in the treatment of lumbar degenerative diseases. Methods A total of 60 patients with lumbar degenerative diseases in Karamay Central Hospital from July 2018 to December 2019 were enrolled and divided into Endo-LIF group (30 cases) and MIS-TLIF group (30 cases) according to the surgery methods. Perioperative parameters, including operation time, estimated blood loss, length of hospital stay, perioperative complications and postoperative fusion rates were recorded, respectively. The Visual Analog Scale (VAS) score for back and leg, the Oswestry Disability Index (ODI) and the Japanese Orthopaedic Association (JOA) score were obtained preoperatively and 1 week, 3 months and 12 months after surgery, respectively. Results There were no significant differences in age, gender, clinical diagnosis, fusion segment and follow-up time between the two groups(P＞0.05). The incision length, intraoperative blood loss and average hospital stay in Endo-LIF group were significantly lower than those in MIS-TLIF group. The VAS scores (lower back pain and leg pain), ODI and JOA scores in the two groups were significantly improved 1 week, 3 months and 12 months after surgery(P<0.05). The VAS score for back pain in Endo-LIF group was significantly lower than that in MIS-TLIF group 1 week and 3 months after surgery (P<0.05). The VAS score, ODI score and JOA score in Endo-LIF group were improved more significantly than those in MIS-TLIF group 3 months after surgery(P<0.05). There were no significant differences in terms of the interbody fusion rate and adverse reaction rate between the two groups(P＞0.05). Conclusions Endo-LIF not only has a good clinical effect in the treatment of lumbar degenerative diseases, but also is a safe,minimally invasive technology, which is worthy of clinical application. References | Related Articles | Metrics

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Effect of MDT immunonutritional support therapy in elderly patients undergoing craniocerebral surgery CHEN Lu, YAO Junying, YU Yongyun, FAN Min 2024, 38 (3):  278-282.  doi: 10.3969/j.issn.1003-9198.2024.03.015 Abstract ( 89 )   PDF (1098KB) ( 592 )   Save Objective To study the therapeutic effect of immunonutritional support under the multidisciplinary team (MDT) model in the elderly patients undergoing craniocerebral surgery. Methods A total of 372 patients aged ≥65 years old who underwent craniocerebral surgery from January 2021 to December 2022 were enrolled and divided into experimental group (73 cases) and control group (299 cases) according to whether MDT immunonutritional support was adopted. And 48 cases were enrolled in experimental group and control group respectively by 1∶1 propensity score matching (PSM). The levels of immunonutritional indexes and inflammational indexes, postoperative complications and prognosis of the two groups were recorded and compared 7 days after treatment. Results After treatment, the levels of prealbumin (PA) and albumin (Alb) were significantly higher, and the levels of procalcitonin (PCT), C-reactive protein (CRP) and interleukin-6 (IL-6) in experimental group were significantly lower than those in control group, with statistical significance (P<0.01). The normal rate of Geriatric Nutritional Risk in experimental group was significantly higher than that in control group (P<0.05). The incidence rates of poor wound healing and postoperative infection in experimental group were lower than those in control group (P<0.05). After treatment, the Glasgow Coma Scale score and the good prognosis rate in experimental group were significantly higher than those in control group (P<0.05). Conclusions MDT immunonutritional support therapy can promote postoperative rehabilitation and prognosis and improve quality of life in the elderly patients undergoing craniocerebral surgery. References | Related Articles | Metrics

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Efficacy of different doses of decitabine in the treatment of elderly patients with myelodysplastic syndrome and the relationship with TP53 gene mutation ZHANG Na, ZHOU Jie, XU Feng, ZOU Wenting, CHENG Lihua, FU Yuanyuan 2024, 38 (3):  283-286.  doi: 10.3969/j.issn.1003-9198.2024.03.016 Abstract ( 85 )   PDF (1076KB) ( 584 )   Save Objective To investigate the efficacy and side effect of different doses of decitabine in the treatment of elderly patients with myelodysplastic syndrome(MDS),and to analyze the correlation of the effect with TP53 gene mutation. Methods A total of 52 patients with MDS admitted in our hospital from April 2020 to May 2022 were enrolled in this study and divided into group A (receiving decitabine 20 mg/d × 5 d, n=28) and group B (receiving decitabine 10 mg/d × 10 d, n=24) according to the indications. The clinical efficacy, toxicity and side effects of the two groups after 6 cycles of treatment were compared, and the correlation of the efficacy with TP53 gene mutation was analyzed. Results The total effective rate was 39.3% in group A,compared with 37.5% in group B(P＞0.05). The incidence rates of grade 3-4 neutropenia, grade 3-4 thrombocytopenia, grade 3-4 anemia, infection, liver damage, fever and gastrointestinal reactions showed no statistical differences between the two groups (P＞0.05). The total effective rate in TP53 mutation group was 83.3%, compared with 12.9% in the wild type group, with significant difference(P<0.01). Conclusions The total effective rate and the incidence of adverse reactions of decitabine 20 mg/d × 5 d and decitabine 10 mg/d ×10 d shows no significant differences. The response rate in patients with TP53 mutation to decitabine is significantly higher than that of patients with wild-type TP53. References | Related Articles | Metrics

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Correlation of white matter lesions and cerebral cortex thickness with cognitive dysfunction after mild stroke in the elderly JIAO Linna, LI Baoyi, WANG Qin, HE Jianli 2024, 38 (3):  287-290.  doi: 10.3969/j.issn.1003-9198.2024.03.017 Abstract ( 90 )   PDF (1071KB) ( 530 )   Save Objective To explore the correlation of white matter lesions and cerebral cortex thickness with cognitive dysfunction after mild stroke in the elderly. Methods A total of 158 elderly patients with mild stroke were selected and divided into non-poststroke cognitive impairment (PSCI) group and PSCI group based on the results of the Montreal Cognitive Assessment Scale (MoCA). The baseline data, MRI images, cerebral cortex thickness of the two groups were compared, and the influencing factors of PSCI for patients with mild stroke were analyzed by multivariate Logistic regression. Results The detection rates of lacunar ischemic lesions, cerebral microbleeds, diffusion weighted imaging (DWI) positive lesions and vascular gap enlargement showed no statistically significant differences between PSCI group and non-PSCI group (P>0.05). The average age of PSCI group was older than that of non-PSCI group, and the severity of white matter lesions was higher than that of non-PSCI group (P<0.05). The cortical thicknesses of the left and right inferior frontal gyrus triangle showed no significant differences between the two groups (P>0.05), but the cortical thicknesses of the left and right orbitofrontal areas, left and right middle frontal gyri in PSIC group were significantly thinner than those in non-PSCI group (P<0.05). Multivariate Logistic regression analysis showed that age and moderate to severe white matter lesions were risk factors for PSCI in the elderly patients with mild stroke (OR=1.704, 1.826, all P<0.05), while prefrontal cortex thickness (left orbitofrontal area, right orbitofrontal area, left frontal gyrus, right frontal gyrus) was a protective factor for PSCI in the elderly patients with mild stroke (OR=0.820, 0.838, 0.834, 0.827, all P<0.05). Conclusions Age, moderate and severe lesions of white matter and the thickness of prefrontal cortex are closely related to PSCI. The status of white matter and cerebral cortex thickness detected by cranial MRI can provide reference for clinical prediction of PSCI. References | Related Articles | Metrics

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Effects of multiple drugs and Barthel index on falls in hospitalized elderly DAI Qian, XIONG Xiaoyan, LU Xuting, LI Lin 2024, 38 (3):  312-316.  doi: 10.3969/j.issn.1003-9198.2024.03.024 Abstract ( 86 )   PDF (1124KB) ( 589 )   Save Objective To investigate the status and influencing factors of falls in hospitalized elderly. Methods A total of 183 elderly patients aged ≥60 years old who were hospitalized in Nanjing First Hospital and suffered from fall in hospital from 2019 to 2021 were enrolled in this study. The general characteristics, comorbidities, drug use and laboratory examination indicators of the patients were collected, and Barthel index score and fall score were evaluated. The basic characteristics of the elderly who fell were analyzed. At the same time, gender- and age- matched 174 elderly hospitalized patients who did not suffer from falls were selected as control group. The differences in the clinical indicators were compared between the two groups, and the risk factors of falls in the elderly were analyzed by multivariate Logistic regression. Results The fall occurred mainly at 6:00-9:00 in the morning (19.8%) and 17:00-20:00 in the evening (17.0%) in 183 elderly falling patients. The main place of fall was in the ward (68.9%), followed by the bathroom (18.0%). Univariate analysis showed that there were statistically significant differences in body mass index (BMI), Na, Cl, Ca, hemoglobin(Hb), albumin, total protein, blood glucose, number of drugs, fall score, Barthel index score and the proportion of insulin, diuretics, antipyretic drugs, sleep aids, painkillers and quinolones used between the two groups. Multivariate analysis showed that BMI, Hb, blood glucose, Na, number of drugs and Barthel index score (41-60) were the influencing factors of falls in hospitalized elderly patients (OR=0.922, 95%CI: 0.857-0.992;OR=0.980, 95%CI: 0.965-0.995; OR=1.345, 95%CI: 1.186-1.527;OR=0.872, 95%CI: 0.804-0.947; OR= 2.957, 95%CI: 1.687-5.181; OR=2.979, 95%CI: 1.157-7.672; OR=4.419, 95%CI: 1.480-13.193, respectively). Conclusions Multiple drug use and decreased self-care ability in the elderly are risk factors for falls, and it is important to prevent them in hospital. References | Related Articles | Metrics

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Predictive value of absolute and relative grip strength for postoperative complications in elderly patients with colorectal cancer YAO Cui, DING Lingyu, HU Jieman, SUN Yueming 2024, 38 (3):  317-321.  doi: 10.3969/j.issn.1003-9198.2024.03.025 Abstract ( 95 )   PDF (1093KB) ( 640 )   Save Objective To investigate the predictive value of absolute and relative grip strength for postoperative complications in the elderly patients with colorectal cancer. Methods A total of 268 elderly patients who underwent elective radical surgery for colorectal cancer in Jiangsu Province Hospital from September 2022 to April 2023 were enrolled in this study. The clinical data including general information, absolute grip strength, relative grip strength (grip strength to weight ratio, grip strength to BMI ratio) and occurrence of complications were collected. Univariate analysis and Logistic regression were used to explore the association between absolute and relative grip strength with postoperative complications. Receiver operating characteristic (ROC) curves were plotted to analyze the ability of absolute and relative grip strength to predict the postoperative complications in the elderly patients who underwent elective radical surgery for colorectal cancer. Results There were significant differences in age, number of drug taken, number of chronic disease, absolute grip strength and relative grip strength between the comorbidity group and non-comorbidity group. The results of Logistic regression showed that low absolute grip strength (classified by guideline or by quartile), low grip strength to weight ratio and low grip strength to BMI ratio were the independent influencing factors of complications, with odd ratio (OR) and 95%CI of 2.825 (1.436-5.557), 3.393 (1.693-6.803), 2.371 (1.210-4.647), and 2.112 (1.074-4.154), respectively. The results of ROC analysis showed that both absolute and relative grip strength (grip strength/weight, grip strength/BMI) were effective in predicting the occurrence of postoperative complications with an AUC of approximately 0.63-0.65, and in male patients, the predictive efficacy of absolute and relative strength was even higher with an AUC of approximately 0.70. Conclusions Both absolute and relative grip strength (grip strength/weight, grip strength/BMI) have a predictive value for postoperative complications in the elderly patients with colorectal cancer. Grip strength assessment can be included in the preoperative evaluation for the elderly patients with colorectal cancer. References | Related Articles | Metrics