脑白质病变及大脑皮层厚度与老年轻型卒中后认知功能障碍的相关性研究

doi:10.3969/j.issn.1003-9198.2024.03.017

Abstract

Abstract: Objective To explore the correlation of white matter lesions and cerebral cortex thickness with cognitive dysfunction after mild stroke in the elderly. Methods A total of 158 elderly patients with mild stroke were selected and divided into non-poststroke cognitive impairment (PSCI) group and PSCI group based on the results of the Montreal Cognitive Assessment Scale (MoCA). The baseline data, MRI images, cerebral cortex thickness of the two groups were compared, and the influencing factors of PSCI for patients with mild stroke were analyzed by multivariate Logistic regression. Results The detection rates of lacunar ischemic lesions, cerebral microbleeds, diffusion weighted imaging (DWI) positive lesions and vascular gap enlargement showed no statistically significant differences between PSCI group and non-PSCI group (P>0.05). The average age of PSCI group was older than that of non-PSCI group, and the severity of white matter lesions was higher than that of non-PSCI group (P<0.05). The cortical thicknesses of the left and right inferior frontal gyrus triangle showed no significant differences between the two groups (P>0.05), but the cortical thicknesses of the left and right orbitofrontal areas, left and right middle frontal gyri in PSIC group were significantly thinner than those in non-PSCI group (P<0.05). Multivariate Logistic regression analysis showed that age and moderate to severe white matter lesions were risk factors for PSCI in the elderly patients with mild stroke (OR=1.704, 1.826, all P<0.05), while prefrontal cortex thickness (left orbitofrontal area, right orbitofrontal area, left frontal gyrus, right frontal gyrus) was a protective factor for PSCI in the elderly patients with mild stroke (OR=0.820, 0.838, 0.834, 0.827, all P<0.05). Conclusions Age, moderate and severe lesions of white matter and the thickness of prefrontal cortex are closely related to PSCI. The status of white matter and cerebral cortex thickness detected by cranial MRI can provide reference for clinical prediction of PSCI.

Key words: poststroke cognitive impairment, mild stroke, white matter lesions of the brain, cerebral cortex thickness, magnetic resonance imaging

CLC Number:

R 749.1

JIAO Linna, LI Baoyi, WANG Qin, HE Jianli. Correlation of white matter lesions and cerebral cortex thickness with cognitive dysfunction after mild stroke in the elderly[J]. Practical Geriatrics, 2024, 38(3): 287-290.

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Correlation of white matter lesions and cerebral cortex thickness with cognitive dysfunction after mild stroke in the elderly

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